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Composition containing cannabidiol and use of composition in treatment of systemic inflammatory response syndrome

A systemic inflammatory response and cannabidiol technology, applied in the field of medicine, can solve problems such as difficulty in obtaining ideal results and failure to find key nodes, and achieve the goal of reducing liver first-pass effect, reducing cytokine storm, and improving treatment level and curative effect Effect

Active Publication Date: 2021-10-22
铸鼎北京医学技术发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Since the occurrence and development of systemic inflammatory response syndrome involves multiple systems and nodes of the nerve-immune-endocrine axis, in such a complex and crisscross system, the existing technology has not found which node is the key node, and the key synergistic target
Therefore, the individual use of various preparations has great limitations, and it is difficult to obtain the desired effect.
It is not yet known whether GABA can assist and promote the normal operation of the endocannabinoid system, whether the combination of the two can improve the overall anti-inflammatory regulation level, whether the two can synergistically and effectively balance endocrine metabolism and immune response, whether they can improve Can the treatment level of systemic inflammatory response syndrome reduce the incidence of multiple organ failure and mortality caused by SIRS? And how to combine the two to achieve the best therapeutic effect? These problems require those skilled in the art to constantly explore and study

Method used

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  • Composition containing cannabidiol and use of composition in treatment of systemic inflammatory response syndrome
  • Composition containing cannabidiol and use of composition in treatment of systemic inflammatory response syndrome
  • Composition containing cannabidiol and use of composition in treatment of systemic inflammatory response syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] The preparation of embodiment 1 microemulsion preparation

[0067] (1) Preparation of emulsifier: Measure 0.5 ml of Tween 80, 0.5 ml of absolute ethanol and 9 ml of normal saline, and mix them with a magnetic stirrer to prepare 10 ml of drug dissolution and emulsifier, which is recorded as the vehicle group.

[0068] (2) Preparation of CBD microemulsion: Measure 0.5 ml of Tween 80 and 0.5 ml of absolute ethanol, add 40 mg of CBD crystal powder (CBD content>98%), mix with a magnetic stirrer for 2 minutes, heat at 60°C and blow , continue to vortex for 5 minutes to promote its full dissolution, mix with 9 ml of normal saline, continue to vortex for 30 minutes, and record it as the CBD microemulsion group.

[0069] (3) Preparation of GABA microemulsion: Measure 0.5 milliliters of Tween 80 and 0.5 milliliters of dehydrated ethanol, mix with a magnetic stirrer, then mix with 9 milliliters of normal saline containing 300 milligrams of GABA (purity 98%), and vortex for 30 Min...

Embodiment 2

[0072] Example 2 The effect of CBD and combined intervention with GABA on the overall performance and survival rate of mice with sepsis (CLP)

[0073] A mouse model of sepsis was constructed by cecal ligation and puncture (CLP). Under the condition of no anti-infection (antibiotics) treatment, the overall survival of sepsis mice in different groups was observed for one week after the intervention of CBD and CBD combined with GABA preparations. status and survival.

[0074] 1) Animal model

[0075] Sixty C57 wild-type mice, male, weighing 20-22 grams, were used. Divided into 6 groups, 10 in each group. Routine 0.5% chloral hydrate intraperitoneal injection anesthesia, using cecal ligation and puncture (CLP) to establish a mouse model of sepsis.

[0076] 2) Model grouping

[0077] (1) CLP+vehicle group (Vehicle): after laparotomy, cecum ligation and perforation were performed, and 100 microliters of the prepared solvent (Vehicle) for dissolving drugs were injected intraperit...

Embodiment 3

[0092] Example 3 Effect of CBD and combined intervention with GABA on peripheral blood cytokines and coagulation function in mice with sepsis (CLP)

[0093] 1. Animal model

[0094] C57 wild-type mice, male, weighing 20-22 grams, were routinely anesthetized by intraperitoneal injection of 0.5% chloral hydrate, and a mouse sepsis model was established by cecal ligation and puncture (CLP). Injury operation and treatment were the same as in Example 2, and a group of healthy controls was added.

[0095] 2. Treatment groups: 70 mice in total, 10 in each group

[0096] (1) Healthy control group: the mice were fasted for 12 hours before operation like other mice, without any surgical treatment, and were given food and water at the same time as other groups after operation.

[0097] (2)CLP+medium group

[0098] (3) CLP+CBD (20mg / kg)

[0099] (4) CLP+GABA (150mg / kg)

[0100] (5) CLP+CBD(20mg / kg)+GBAB(150mg / kg)

[0101] (6) CLP+ Taineng (imipenem cilastatin sodium for injection) (25...

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Abstract

The present invention relates to a composition containing cannabidiol and use of the composition in the treatment of systemic inflammatory response syndrome. The composition provided by the invention comprises cannabidiol and gamma-aminobutyric acid. Various preparations are prepared by compounding and emulsifying cannabidiol and gamma-aminobutyric acid, and can be used for treating or relieving systemic inflammatory response syndromes caused by various external causes or internal causes or reducing cytokine storm and the degree of tissue and organ injury caused by cytokine storm. In the application of the composition, in order to avoid the first pass effect of liver enzyme metabolism and improve the bioavailability of fat-soluble substances and water-soluble substances, oral administration, nasal spray, nasal smearing and transdermal administration (acupoint application, massage or injection) modes can be adopted. The composition disclosed by the invention has an obvious treatment effect on the systemic inflammatory response syndrome caused by acute body injuries such as bacterial infection, trauma and shock, and also has a potential application prospect in the systemic inflammatory response syndrome occurring in virus infection, advanced cancer or an immunotherapy process.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a composition containing cannabidiol and its application in treating systemic inflammatory response syndrome. Background technique [0002] Systemic inflammatory response syndrome (SIRS) is a pathophysiological process in which the body releases a large number of inflammatory cells and humoral mediators after severe injury stimulation, and even produces a cytokine storm, resulting in extensive tissue damage. Factors causing SIRS include infection or non-infection. Infectious factors include systemic infections caused by viruses, bacteria, fungi, etc., clinically seen in severe respiratory distress syndrome (ARDS) caused by coronaviruses (SARS, MERS, COVID-19); biliary tract infections, intestinal infections, abdominal cavity infections caused by bacteria Infection, trauma infection, etc.; non-infectious factors include common trauma, hemorrhagic shock, ischemia-reperfusion inju...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/197A61K9/107A61K47/26A61K47/44A61K47/24A61P31/04A61P31/12A61P29/00A61P25/08A61P25/16A61P25/28A61P25/24A61P7/04A61P25/20A61K31/05
CPCA61K31/05A61K31/197A61K9/1075A61K47/26A61K47/44A61K47/24A61P31/04A61P31/12A61P29/00A61P25/08A61P25/16A61P25/28A61P25/24A61P7/04A61P25/20A61K2300/00Y02A50/30
Inventor 徐迎新陈霄贾宁
Owner 铸鼎北京医学技术发展有限公司
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