Hollow fiber heterogeneous membrane as well as preparation method and application thereof

A hollow fiber technology, applied in the field of hollow fiber heteromembrane and its preparation and application, can solve the problems affecting oxygenation membrane performance, many modification steps, platelet adhesion, etc., and achieves remarkable surface modification effect and high gas permeability. The effect of improving performance and blood compatibility

Pending Publication Date: 2022-07-15
TIANJIN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, directly prepared polymer membranes are often not biocompatible and difficult to meet clinical needs, especially when in contact with blood, reactions such as platelet adhesion, hemolysis, and coagulation are prone to occur, which seriously affects the performance of oxygenated membranes.
Therefore, it is necessary to improve the blood compatibility of the membrane through surface modification. However, since the surface of the PMP membrane has only methyl and methylene groups and no active groups, i

Method used

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  • Hollow fiber heterogeneous membrane as well as preparation method and application thereof
  • Hollow fiber heterogeneous membrane as well as preparation method and application thereof
  • Hollow fiber heterogeneous membrane as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A block copolymer modified heterogeneous PMP hollow fiber oxygenation membrane is prepared, and the preparation steps are as follows:

[0029] Step 1. Take 200g of PMP raw material, 800g of dioctyl phthalate and 20g of polyethylene-block-poly(ethylene glycol) respectively and add them to the feed liquid kettle, and stir the casting liquid at 240°C for 6h until a homogeneous phase is formed. solution, let stand for defoaming for 12h.

[0030]Step 2. The homogeneous film casting liquid obtained in step 1 is extruded through a high-temperature spinneret at a rate of 15ml / min, and the flow rate of the core liquid used to form the hollow structure is 40ml / min, and then it is solidified and formed by cooling water and completed. The surface of the block copolymer is enriched, and then the winding is completed by the winding wheel, and the winding speed is 1.15 m / s.

[0031] Step 3. Soak the membrane obtained in Step 2 in absolute ethanol for 48h to make it fully extracted. ...

Embodiment 2

[0034] To prepare a block copolymer-modified heterogeneous PMP hollow fiber oxygenation membrane, the preparation steps of Example 2 are basically the same as those of Example 1, except that in Step 1, the amphiphilic block copolymer was changed from 20 g The polyethylene-block-poly(ethylene glycol) was changed to 15g of Pluronic F127, the quality of PMP raw material was changed from 200g to 300g, and the quality of dioctyl phthalate was changed from 800g to 700g. In step 2, the extrusion speed of the feed liquid in the process conditions of extrusion molding and winding and winding was changed from 15ml / min to 23ml / min, and the flow rate of the core liquid was changed from 40ml / min to 50ml / min; finally obtained The membrane is denoted as membrane 2.

[0035] Measured according to the same test method of Example 1: the water contact angle of the membrane 2 is 83°; the hemolysis rate is 5.33%; the oxygen permeation rate is 1.79ml / (min·cm 2 bar).

Embodiment 3

[0037] A block copolymer modified heterogeneous PMP hollow fiber oxygenation membrane was prepared,

[0038] The preparation steps of Example 3 are basically the same as those of Example 1, except that in Step 1, the amphiphilic block copolymer was changed from 20g polyethylene-block-poly(ethylene glycol) to 45g ethylene-ethylene. Alcohol copolymer (EVOH). In step 2, the extrusion speed of the feed liquid in the process conditions of extrusion molding and winding and winding was changed from 15ml / min to 7.5ml / min, the flow rate of the core liquid was changed from 40ml / min to 20ml / min, and the The rotation speed of the winding wheel (ie, the speed of wire take-up) was changed from 1.15m / s to 0.64m / s, and the film finally obtained was recorded as film 3.

[0039] Measured according to the same test method of Example 1: the water contact angle of the membrane 3 is 66°; the hemolysis rate is 3.49%; the oxygen permeation rate is 1.88ml / (min cm 2 bar).

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Abstract

The invention discloses a hollow fiber heterogeneous membrane as well as a preparation method and application thereof. The oxygenated membrane is prepared by taking poly-4-methyl-1-pentene as a membrane material and dioctyl phthalate as a diluent through a thermally induced phase separation method. The preparation method comprises the following steps: blending an amphiphilic block copolymer in a membrane casting solution, extruding the uniformly mixed membrane casting solution through a spinning nozzle, performing phase separation and curing in a cooling water bath, spontaneously enriching a hydrophilic chain segment to the surface of the membrane, anchoring a polymer matrix by a hydrophobic segment, and realizing in-situ surface modification of the membrane. And subsequently, extracting, drying and the like to obtain the heterogeneous PMP oxygenation membrane with a hydrophilic surface and a hydrophobic main body. The method has the advantages of simplicity in operation, high controllability, capability of realizing one-step modification and the like. When the prepared modified membrane is applied to in-vitro membrane oxygenation, the blood compatibility of the membrane is obviously improved, and meanwhile, the original high gas permeability of the PMP membrane is still kept.

Description

technical field [0001] The present invention relates to the field of membranes, in particular to a poly-4-methyl-1-pentene (PMP) hollow fiber oxygenation membrane whose surface is modified by a block copolymer, and a preparation method and application thereof. Background technique [0002] Extracorporeal Membrane Oxygenation (ECMO) is an extracorporeal life support system that draws low-oxygen, high-carbon dioxide venous blood from a patient through a blood pump, flowing through an oxygenator, between the blood and the purge gas. The exchange of oxygen and carbon dioxide, which is then returned to the human body, is often used to oxygenate the blood and remove carbon dioxide, so it is also called an artificial lung. In recent years, the demand for ECMO has been increasing year by year, and it has been widely used in the treatment of acute respiratory failure, lung transplantation, cardiovascular diseases, etc. ECMO provides cardiopulmonary auxiliary support for patients in v...

Claims

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Application Information

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IPC IPC(8): B01D69/08B01D69/02B01D67/00B01D71/26A61M1/36A61M1/16
CPCB01D69/08B01D69/02B01D67/0002B01D71/26A61M1/3666A61M1/1621A61M1/3621B01D2325/36
Inventor 潘福生姜忠义张润楠邵丽萍李彤高文卿杜宇倩郭宇航于诗瑶
Owner TIANJIN UNIV
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