The invention discloses a multi-airspace trajectory planning and a negotiation method oriented to four-dimensional track operation, and belongs to the field of air traffic management. The method firstly obtaining a flight plan, an airspace capacity, an airport available time slots, and an air traffic flow management policy information, determining the criteria for interplay between the flight trajectories of flight segments, defining a control airspace and an intermediate airspace, generating an airspace flight interaction relation matrix, and in this way, determining the flight trajectory scope that needs to be prioritized, adjusting the trajectory by changing the key point time and height, iteratively updating the matrix until the number of interdependent flights is zero, planning the result and determining the executability in trajectory sharing and negotiation. According to the multi-airspace trajectory planning and negotiation method oriented to four-dimensional track operation, the technical support can be provided for the development of a hollow tube automation system and a control auxiliary decision tool which support four-dimensional track operation.