The invention discloses a method for evaluating operation quality of information systems. The method comprises the steps of firstly, constructing an evaluation index system for the operation quality of information systems; secondly, using an analytic hierarchy process to evaluate the operation quality of the qualitative information system and calculate the subjective weight of evaluation indexes, using an entropy weight method to evaluate the operation quality of the quantitative information system and calculate the objective weight of evaluation indexes, and synthesizing the subjective weight of evaluation indexes and the objective weight of evaluation indexes to calculate the combined weight of all evaluation indexes; and finally, calculating evaluative values of all evaluation objects according to the combined weight, and conducting evaluation analyses on evaluative values of all evaluation objects. According to the method, the entropy weight method and the analytic hierarchy process are combined to evaluate the operation quality of information systems, the potential problems in operation of information systems are found out, the operation guaranteeing capability of information systems is improved, and the operation and maintenance level of information systems is evaluated accurately and objectively, so that the safe, high-efficiency and economical operation of information systems is effectively guided.