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37 results about "Bioindicator" patented technology
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A bioindicator is any species (an indicator species) or group of species whose function, population, or status can reveal the qualitative status of the environment. For example, copepods and other small water crustaceans that are present in many water bodies can be monitored for changes (biochemical, physiological, or behavioural) that may indicate a problem within their ecosystem. Bioindicators can tell us about the cumulative effects of different pollutants in the ecosystem and about how long a problem may have been present, which physical and chemical testing cannot.
Automated biological indicator incubator
InactiveUS20060263258A1Analysis using chemical indicatorsHeating or cooling apparatusCommunication interfaceTemperature control
A system and method of automated incubating and reading of biological indicators is disclosed. In one embodiment, the automated biological indicator incubator is configured to control the temperature of incubation test wells to a desired temperature range suitable for use with a biological indicator, control the incubation period, and detect a change in the biological indicator colored media providing an indication of growth or lack of growth. In other embodiments, the automated biological indicator incubator is self-calibrating, and provides a communication interface to an external device, such as a computer. The communication interface is suitable for use to collect and analyze data associated with the biological indicator during the incubator period, and for making a determination of growth or lack of growth and success of the sterilization process as well as a permanent document of the monitoring of the sterilization process.
Owner:HARRIS MATTHEW +3
Vapor phase decontamination process biological indicator evaluator resistomer (BIER) vessel
InactiveUS6936434B2Evenly distributedApparent advantageBioreactor/fermenter combinationsBiological substance pretreatmentsEngineeringVapor phase
A BIER vessel evaluates biological indicators for sterilization processes. By flowing gaseous sterilant, such as vaporized hydrogen peroxide, through a chamber (12) before, during, and after introducing the indicators, the indicators are instantaneously exposed to preselected steady state conditions, allowing accurate and reproducible evaluation of the indicator response. A door (32) to an opening (30) in the chamber opens for introducing the indicators to the chamber without appreciably disturbing the steady state conditions therein. After a preselected time, the biological indicators are removed and evaluated for remaining biological activity.
Owner:AMERICAN STERILIZER CO
Sensors with variable response behavior
InactiveUS20030062263A1Few false alarmStrong specificityImmobilised enzymesBioreactor/fermenter combinationsChemical agentThiophosphate
A sensor and method for detecting biological and chemical agents comprising metal interdigitized electrodes coated with hybrid polymer-based conducting film and an instrument for applying electrical voltage to the electrodes and registering the change in electrical current. The hybrid film also comprises indicator biomolecules encapsulated within the film or attached to it. The bioindicator molecules preferably comprise enzyme acetylcholinesterase. When these indicator biomolecules come in a contact with a pathogen, chemical and / or morphological changes occur in the film and electrical current flowing through the electrodes is modulated. The pathogen comprise inhibitors of enzymes, preferably organophosphates, thiophosphates or phosphonates. The change in current indicates the presence of a biological and chemical agent and is registered.
Owner:HRL LAB
Genetically encoded bioindicators of calcium-ions
InactiveUS20090035788A1Superior for dynamic imagingPoor behaviourFermentationVector-based foreign material introductionFörster resonance energy transferIon
The present invention relates to novel types of cellular calcium probes that are based on Troponin C and two chromophors suitable for FRET (fluorescence resonance energy transfer). The Troponin C-based calcium sensors of the invention function in diverse subcellular environments, for example even when tethered to a cellular membrane. The invention further provides nucleic acid constructs encoding the calcium probes of the invention, expression constructs, host cells and transgenic animals. Furthermore, methods for the detection of changes of local calcium concentrations and for detecting the binding of a small molecule to fragments of Troponin C are provided.
Owner:MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN EV
Device and method for rapidly determining the effectiveness of sterilization or disinfection processes
A device and a method for rapidly determining the effectiveness of sterilization or disinfection processes are provided. The method involves contacting a biological indicator containing a known number of live spores to a sterilization or disinfection process. When the spores are killed, the minerals in the spores are released. Water is contacted with the dead spores to form an aqueous solution. A parameter related to the concentration of a mineral in the aqueous solution is measured. The effectiveness of the germicidal process is determined from the parameter and the initial number of spores in the biological indicator. Measuring the parameter by measuring the conductivity of the aqueous solution is particularly effective and sensitive.
Owner:ETHICON INC
Biological indicator and method for producing the same
InactiveUS20090068716A1Correct effectivenessHigh sensitivityBioreactor/fermenter combinationsBiological substance pretreatmentsBioindicatorElectrical and Electronics engineering
Owner:NGK INSULATORS LTD
Biological indicator
ActiveUS20060269983A1Effective disinfectionEffective sterilizationBioreactor/fermenter combinationsBiological substance pretreatmentsSporeMicroorganism
A biological indicator for monitoring the effectiveness of a sterilizing, disinfecting, etc., compound or condition is disclosed which comprises a substrate having a surface layer containing functional groups thereon desirably free of silicone linking groups. The functional groups are desirably in the form of a monolayer of a uniformed distribution and of a selected quantity. Various types of microorganisms such as spores and / or etiological agents are covalently bonded to the surface layer functional groups through a crosslinking reagent and thus form a uniform number and distribution of the microorganisms and / or etiological agents. After being subjected to sterilization or other similar treatment, etc., along with various articles such as instruments, the indicator can be cultivated to determine the effectiveness of the sterilization, disinfection, etc. process.
Owner:AMERICAN STERILIZER CO
Therapeutic and protective dental device useful as an intra-oral delivery system
InactiveUS20080096162A1Promote absorptionMaximize of contactCosmetic preparationsImpression capsAntibiotic YDelivery system
A dental device has a U-shaped carrier with at least one channel for embracing an arch of teeth. The carrier has recessed insets in the channel. Discrete inserts carrying a beneficial agent can fit into the insets and release the agent gradually. When the device is used in a primarily therapeutic application, the inserts may be installed into all or less than all of the insets to form various insert patterns. Thus, different oral regions can be affected by different insert patterns. When the device is used as an athletic mouthguard, temporary blanks may be initially fitted in the insets, while a portion of the mouthguard is softened before an arch of teeth is pressed into the channel to make a custom impression. The inserts that are later installed in the insets possess different physical properties than the carrier and may be positioned and shaped to mechanically buffer teeth of the arch from mechanical shocks as well as release beneficial agents. The inserts may be replaced or refreshed to maintain the beneficial agent, which may be xylitol, remineralizing agents, moisturizing agents, desensitizing agents, flavoring agents, breath fresheners, chemical and biological indicators, nutraceuticals, antibiotics, probiotics, other medications and chemotherapeutics, or other agents.
Owner:DYNAMIC MOUTH DEVICES
Volatile Organic Gases as Bioindicators for Transplant Rejection
InactiveUS20150031582A1Library screeningMaterial analysis by electric/magnetic meansVolatile organic compoundChemistry
A method comprising (a) obtaining one or more biological samples from a subject wherein the subject has undergone an organ transplant; (b) determining the amount and type of one or more volatile organic compounds in the biological sample; and (c) correlating the amount of volatile organic compounds to a degree of transplant rejection. A device comprising a plurality of sensors configured to detect a plurality of volatile organic compounds in a biological sample of a subject having undergone an organ transplant.
Owner:UNIV HOUSTON SYST +2
Biological indicator with integral package
ActiveUS8765398B2Avoid accidental contaminationEasy to handleBioreactor/fermenter combinationsBiological substance pretreatmentsAdhesiveMechanical engineering
Owner:MESA LABORATORY
Biological indicator for use with vaporous microbial deactivating agents and method for making same
InactiveUS20080206801A1Minimal materialMinimizes stackingApparatus sterilizationMicrobiological testing/measurementMicroorganismChlorine dioxide
A biological indicator and method of making same. The biological indicator includes a carrier having a recess formed therein in order to restrict movement of an inoculum deposited onto the carrier. The inoculum includes microorganisms (e.g., bacterial spores) suspended in a suspension medium. The microorganisms are prepared by removing extraneous material and subjecting the microorganisms to sonication to break up agglomerations. The suspension medium includes a wetting agent to reduce surface tension, thereby facilitating flow of the suspension medium to prevent stacking of microorganisms on the surface of the carrier, and to allow the inoculum to more evenly “plate out” on carrier surfaces. The carrier, with inoculum deposited thereon, is enclosed in an envelope made of a material permeable to a vaporous deactivating agent (e.g., vaporized hydrogen peroxide, ozone, chlorine dioxide, ethylene oxide, etc.), thereby facilitating exposure to the vaporous deactivating agent.
Owner:AMERICAN STERILIZER CO
Wellness healthcare and personalized medicine system
InactiveUS20140019151A1Good for healthData processing applicationsMedical automated diagnosisPersonalizationBiomedical engineering
Methods, devices and systems for performing personalized wellness healthcare by forming a patient personal assessment using one or more bioindicator levels and one or more personal indicator communications. A processor assigns relational impact factors to the input, and a differentiator determines a diagnosis or prognosis based on normal and disease states. A treatment and / or wellness plan can be generated. The methods, devices and systems can be operated in a kiosk, and / or remotely.
Owner:PERMESYS
Use of Holographic Sensor to Determine Sterilisation
InactiveUS20080297864A1Improve accuracyFast resultsMicrobiological testing/measurementLavatory sanitorySterilisation procedureFluorophore
In a method of determining the effectiveness of a sterilization procedure using a biological indicator, the biological indicator comprises a holographic sensor and spores or an enzyme. The method and the biological indicator rely on the holographic sensor to indicate the effectiveness of me sterilisation procedure and do not require a conventional pH indicator, a fluorophore or chromophore.
Owner:SMART HOLOGRAMS
Sterilization process challenge pack
ActiveUS20190307911A1Microbiological testing/measurementLavatory sanitoryBiomedical engineeringPeripheral
A sterilization process challenge pack including a base tray, a first cover, and a second cover is configured to provide a restrictive flow path for gaseous sterilization medium to test the efficacy of a sterilization process. The base tray includes at least one chamber containing a biological indicator and / or chemical indicator. The first cover including a notch is configured to cover the at least one chamber. The second cover is attached to peripheral surfaces of the base tray except at an unsealed portion. A flow path through the unsealed portion and the notch in the first cover provides the only fluid communication between an external environment and the at least one chamber.
Owner:AMERICAN STERILIZER CO
Blood and urine test
InactiveUS20070031915A1Application to testingBiocideHeavy metal active ingredientsAntibiotic YUrine production
The present invention provides a test medium comprising a test microorganism, an indicator and a metal in ionized form, wherein the valence of said metal is at least 2 and the concentration of said metal is between 0.001 M and 1 M. Furthermore, there is provided a method for the determination of the presence of an antibiotic characterized in that a metal salt is added to said test medium and / or to said sample of fluid. Finally, there is provided a kit suitable for the determination of an antibiotic in a fluid.
Owner:R BIOPHARM
High throughput biological indicator reader
InactiveCN1767861AImprove throughputImprove detection accuracyMicrobiological testing/measurementLavatory sanitoryBiochemistryIncubator
A high capacity reader detects fluorescence emitted by a biological indicator to determine the efficacy of a sterilization cycle. The reader permits a large number of biological indicators to be read in rapid succession. For example, the biological indicators may be pre-incubated in a separate, high capacity incubator and then placed in a high capacity reader for fluorescence detection. The reader makes a positive or negative growth determination based on a single fluorescence threshold comparison for each pre-incubated biological indicator. The single fluorescence threshold comparison involves comparison of measured fluorescence to a baseline fluorescence of a reference biological indicator. The reader acquires the baseline fluorescence from the reference biological indicator, and thereafter uses the baseline fluorescence as the threshold for subsequent biological indicators processed by the reader. In addition, the reader may generate output for storage, processing and display of biological indicator results.
Owner:3M INNOVATIVE PROPERTIES CO
Detection reagent kit and method of heat-resistant microorganisms in elemene lipidosome injection semi-finished products
InactiveCN105779563APollution status is convenientEnsure safetyMicrobiological testing/measurementWater bathsClosed loop
The invention relates to a detection reagent kit and method of heat-resistant microorganisms in elemene lipidosome injection semi-finished products and belongs to the technical field of medical instruments and detection means. The detection reagent kit contains sterile elemene standard injection and heat-resistant microorganism biological indicator. The detection steps include S1 screening heat-resistant microorganisms in the elemene lipidosome injection semi-finished products by the boiling water bath; S2, separating, identifying and storing heat-resistant bacteria of bacillus; S3, preparing spore liquid of the heat-resistant bacteria prepared in the step S2, and calibrating concentration of spore liquid; S4, preparing biological indicator by products obtained in the step S3, and calibrating concentration of the biological indicator; S5, boiling quantitatively. The detection reagent kit fills the blank of the related technology and forms the detection technology of a complete closed loop from inspection, evaluation and treatment of heat-resistant microorganisms. The detection reagent kit helps detectors detect the pollution state of elemene, labor is saved, and detection efficiency is improved.
Owner:JINGANG PHARMA DALIAN
Multifunctional biomedicine instrument
PendingCN106893666AIncrease volumeBig spaceBioreactor/fermenter combinationsBiological substance pretreatmentsBiomedicineCryopreserved Cell
The application discloses a multifunctional biomedicine instrument, comprising a working host machine, an ozone generator, a cover body and a bottom plate, wherein the working host machine comprises a substrate and a function cabin arranged at the substrate; the ozone generator is located in the substrate; the working host machine is placed on the bottom plate; the cover body is covered on the bottom plate to form a closed space; the substrate, the function cabin and the ozone generator are located in the closed space. Therefrom, the working host machine is placed in the closed space through the closed space formed by the cover body and the bottom plate, then the working host machine is disinfected by an ozone generator; the working host machine can perform the ozone disinfection before or after working every time, thereby preventing operation samples and working environments from being polluted; through matching with different function components, the working host machine can realize cryopreserved cell dry type recovery, constant temperature incubation of microorganism, stability temperature oscillation of a microwell plate, wane table shaking, metal bath, constant temperature incubation of a biological indicator, cell heat shock cultivation, and others.
Owner:赛慕特生物工程(上海)有限公司
Autoclave Biological Indicator Retrieval Device with Steam and Pressure Pass-through Tube
InactiveUS20200237945A1Improve the bactericidal effectLavatory sanitoryMedical waste disposalProcess engineeringEnvironmental engineering
During autoclave sterilization, technicians often tighten waste bags too tight not allowing proper steam permeation into the items in the autoclave bag. Additionally, biological indicators (bioindicators) should be used to confirm sterilization of items in the waste bag; however it is recommended that these indicators be placed close to the center of the bag to give a more accurate representation of sterilization. This is not safely feasible due to the need to probe into a waste bag for placement and retrieval of biological indicators after autoclaving. This device addresses both of these technical problems. Placing it in an autoclave bag cinched at the composite collar allows steam to penetrate into the autoclave bag via a pass-through tube close to the center mass of the waste bag. Additionally, this device holds many types of biological indicators allowing them to be safely placed and retrieved from center mass of an autoclave bag.
Owner:GOFORTH CHRISTOPHER BRADLEY
Process for determining viability of test microorganisms of biological indicator and sterilization detection device for determining same
ActiveUS10900062B2Apparatus sterilizationMicrobiological testing/measurementBiotechnologyMicroorganism
A process for determining the viability of a biological indicator includes exposing the biological indicator to a viability detection medium, the biological indicator including test microorganisms, the exposing the biological indicator to the viability detection medium producing a gaseous reaction product when one or more of the test microorganisms are viable. The presence or absence of the gaseous reaction product produced by the biological indicator combined with the viability detection medium is detected with a sensing device, the sensing device comprising a resistive sensor, wherein the presence of the gaseous reaction product indicates the presence of viable test microorganisms and the absence of the gaseous reaction product indicates the absence of viable test microorganisms. A sterilization detection device includes a container configured to contain the biological indicator, a viability detection medium, and the sensing device.
Owner:AMERICAN STERILIZER CO
Biological indicator for monitoring sterilization effect and preparation method thereof
The invention discloses a culture medium for spore germination and growth, a biological indicator prepared by using the culture medium and corresponding preparation methods of the culture medium and the biological indicator. Through the specific culture medium, the spore germination and acid production time is shorter, the response value detected by a biological indicator reader is higher, the response time is shorter, the spore germination detection result is faster and more accurate than that of mature biological agents in the current market on the whole, and thus, the application and popularization value is achieved.
Owner:CHENGDU MEDICAL COLLEGE
Ampoule piercing mechanism for biological indicators
InactiveCN110844274BReduces the risk of accidental puncturesImprove reliabilityClosuresContainers with multiple articlesMedicineEngineering
Owner:QINGDAO UNIV
Containers for Biological Indicators
ActiveCN110862920BPromote circulationImprove liquidityBioreactor/fermenter combinationsBiological substance pretreatmentsMedicineEngineering
The invention relates to a biological indicator for sterilization of medical instruments, in particular to a container for the biological indicator. The container comprises an outer pipe and a cap. The cap is mounted at the upper end of the outer pipe; a cap through hole communicated with a pipe cavity of the outer pipe is formed in the cap; an outer pipe end wall is arranged at the lower end of the outer pipe; and the outer pipe end wall is provided with an end wall through hole communicated with the pipe cavity of the outer pipe. The end wall through hole is formed in the outer pipe end wall, so that the end wall through hole, the pipe cavity of the outer pipe and the cap through hole are communicated to form a smooth gas flow path; the gas flow path is used for circulation of steam in the disinfection process of a pressure steam sterilizer; and the steam circulation effect of the outer pipe can be improved by utilizing the convection principle, so that bacterial flakes in the container can be in more sufficient contact with the steam, and the indication of the biological indicator is more accurate.
Owner:山东贝瑞康生物科技有限公司
Biological indicator for rapid verification of disinfection or sterilization
InactiveUS20220125981A1Rapidly verify resultQuick verificationBacteriaApparatus sterilizationMicroorganismEnvironmental engineering
The present invention provides a biological indicator for verification of disinfection or sterilization, and in particular, provides a biological indicator capable of verifying disinfection or sterilization using luminescent microorganisms, and a kit for verification of disinfection or sterilization using the biological indicator. According to the present invention, it is possible to provide a biological indicator for verification of disinfection or sterilization that may confirm in real time how much disinfection or sterilization has been performed after disinfecting or sterilizing harmful microorganisms by irradiation with UV rays.
Owner:ADEN HYGIENE ENT
Container for biological indicator
ActiveCN110862920APromote circulationImprove liquidityBioreactor/fermenter combinationsBiological substance pretreatmentsMedicineBiological organism
The invention relates to a biological indicator for sterilization of medical instruments, in particular to a container for the biological indicator. The container comprises an outer pipe and a cap. The cap is mounted at the upper end of the outer pipe; a cap through hole communicated with a pipe cavity of the outer pipe is formed in the cap; an outer pipe end wall is arranged at the lower end of the outer pipe; and the outer pipe end wall is provided with an end wall through hole communicated with the pipe cavity of the outer pipe. The end wall through hole is formed in the outer pipe end wall, so that the end wall through hole, the pipe cavity of the outer pipe and the cap through hole are communicated to form a smooth gas flow path; the gas flow path is used for circulation of steam in the disinfection process of a pressure steam sterilizer; and the steam circulation effect of the outer pipe can be improved by utilizing the convection principle, so that bacterial flakes in the container can be in more sufficient contact with the steam, and the indication of the biological indicator is more accurate.
Owner:山东贝瑞康生物科技有限公司
Biological indicators
PendingCN108699587AResistance level controlFulfil requirementsApparatus sterilizationMicrobiological testing/measurementBiotechnologyBiochemical engineering
This invention relates to a biological indicator, comprising: a carrier inoculated with a test organism and an effective amount of a carbohydrate to reduce the resistance of the biological indicator to steam sterilization. The invention relates to a steam sterilization process using the biological indicator.
Owner:AMERICAN STERILIZER CO
Biological indicator for determining the efficacy of a steam or heat sterilization process and its method of use
PendingUS20210047673A1Many timesMinimizing chanceBacteriaMicrobiological testing/measurementBiotechnologyMicroorganism
The invention relates to a biological indicator for determining the efficacy of a steam or heat sterilization process, and its method. The biological indicator comprises microbial spores (a), at least one sensor protein exogenous to the microbial spores (b), one fluorophore (c), and a culture medium (d). The invention also refers to the method of use of this biological indicator. This method consists of (a) placing the biological indicator along with a target material to be steam or heat sterilized within a steam or heat sterilizer, (b) carrying out a steam or heat sterilization process, (c) placing the biological indicator in a an incubator, (d) screening the biological indicator for immediate detectable changes in fluorescence intensity, while incubating the biological indicator in the incubator, (e) determining the efficacy of the steam or heat sterilization process based on the screening carried out during step d), (f) extending the incubation of the biological indicator obtained in step d), (g) screening the incubated biological indicators obtained in step e) for an optically detectable color change, and (h) determining the efficacy of the steam or heat sterilization process, according to optically detectable changes obtained in step g).
Owner:TERRAGENE SA +1
Self-contained type biological indicator container
PendingCN110903953AFree from destructionAvoid external pollutionBioreactor/fermenter combinationsBiological substance pretreatmentsBiotechnologyVaccination
The invention discloses a self-contained type biological indicator container. As an improvement, the self-contained type biological indicator container comprises a culture medium container and an upper end cover which is hermetically matched with the culture medium container, wherein a blocking seal layer is arranged on the culture medium container; the container is divided into an upper cavity body and a lower cavity isolating from each other through the blocking seal layer; an enclosed cavity body is formed by the upper cavity body and the upper end cover; allowance which can be relatively shifted in the axial direction is reserved between the upper end cover and the container; and a protruding breaking layer part is arranged on a part, corresponding to the blocking seal layer, of the inner part of the blocking seal layer. According to the self-contained type biological indicator container disclosed by the invention, both of a biological indicator carrier and a culture medium are sealed in the container and are isolated from the outside, so that external pollution is completely and effectively avoided; and in addition, the upper cavity body is arranged close to the upper part ofthe container, and a cavity body for storing the biological indicator carrier is formed by the upper cavity body and the upper end cover, so that disinfection and sterilization are conveniently carried out; and cooperation of the biological indicator carrier and the culture medium only requires pressing and rotation of the upper end cover. The self-contained type biological indicator container disclosed by the invention has a simple structure, is convenient to operate, and has no need of damaging of the container; and due to transferred vaccination, external interference is effectively avoided.
Owner:浙江泰林生命科学有限公司
Biological indicators, and systems and methods for determining efficacy of sterilization
ActiveUS20220170067A1Improve accuracyImprove sterilityApparatus sterilizationMicrobiological testing/measurementSporelingBiology
A biological indicator includes: a BI housing; a germinant container inside the BI housing and housing a germinant composition; a germinant releaser configured to release the germinant composition from the germinant container; a germinant releaser support supporting the germinant releaser and configured to bring the germinant releaser into contact with the germinant container upon application of a force to the germinant releaser support or the germinant container; a first spore carrier inside the BI housing, the first spore carrier having a plurality of spores deposited at a first surface thereof; and an imaging window at a first surface of the BI housing. A BI reader is configured to detect and quantify the presence of live spores in the BI, and includes an excitation source, a camera for capturing images of the spores over time, and a processor for analyzing the images to determine the presence of live spores.
Owner:STERITEC PROD MFG CO INC
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