20 results about "Donors blood" patented technology

The invention discloses blood component single sampling equipment capable of monitoring in real time in the field of blood treatment equipment. The equipment comprises a blood sampling module, a centrifugal separation module, a component collection module and an anticoagulant conveying module, and further integrates a multi-dimensional real-time monitoring system and a closed-loop self-adaptive regulation and control module. The multi-dimensional real-time monitoring system comprises an online micro-fluidic component detection unit, a physiological parameter monitoring unit and an equipment operation monitoring unit, can realize real-time online detection of blood component purity, cell activity and pollutant residue in the separation process, and synchronously monitors circulation physiological parameters of a blood donor and an equipment operation state at the same time; the closed-loop self-adaptive regulation and control module can dynamically adjust parameters such as the centrifugal rotating speed, the fluid pump speed and the anticoagulant ratio according to real-time monitoring data, and precise closed-loop control over the separation process is achieved. The quality stability of blood single-sampling components can be remarkably improved, meanwhile, the operation risk is greatly reduced, and the method is suitable for clinical blood component single-sampling and preparation scenes.

The utility model belongs to the technical field of medical instruments, particularly relates to a special test tube rack for manual cross matching test, and provides the following scheme aiming at the problems that test tubes are easy to be disordered together and are inconvenient to distinguish due to the fact that excessive test tubes are placed in the existing technical scheme: the special test tube rack comprises a base, two clamping covers are symmetrically and fixedly installed on the top of the base, two vertical plates are symmetrically and fixedly installed on the top of the base, and the number of the vertical plates is two. By arranging the clamping positions of the two test tubes, the test tubes containing serum of a blood receiver and red blood cell suspension of a blood supplier can be supported and limited; according to the test tube clamping device, the problem of errors can be avoided during a test, the success probability of the test can be improved, and stable limiting can be realized when the test tube is clamped, so that serum of a blood receiver and erythrocyte suspension of a blood donor can be stably protected.

The utility model relates to the technical field of medical instruments, in particular to a blood vessel anastomosis device which comprises a pair of triangular anastomosis devices, through holes are formed in the anastomosis devices, and anastomosis rings are arranged in the through holes. Coordination needles and coordination holes which are matched with each other are arranged on the opposite faces of the pair of anastomators in a staggered mode, and anastomosis forceps are arranged in a mode of being matched with the anastomators. An embedding device is arranged on the anastomosis forceps, a triangular embedding groove matched with the anastomat is formed in the embedding device, the embedding device is further arranged to be of a telescopic structure, and an adjusting mechanism capable of adjusting the distance between two forceps rods of the anastomosis forceps is arranged at the rotating connecting position of the anastomosis forceps in a matched mode. The end-to-end anastomosis and end-side anastomosis of the blood vessel can be simultaneously adapted, a 45-degree included angle between a donor blood vessel and a receptor blood vessel can be formed in the end-side anastomosis, the design of hemodynamics is met, the effect of blood vessel anastomosis is effectively improved, and the risk of various postoperative complications is reduced.

The invention provides a double-position centrifugal plasma purification system, and belongs to the technical field of plasma purification. Comprising a plasma collection system, a plasma adsorption system and a liquid feedback system, the plasma collection system and the liquid feedback system are both connected with a blood supplier to form a blood closed-loop conveying loop, and the plasma adsorption system is connected with the plasma collection system and the liquid feedback system; the plasma collecting system comprises two centrifugal machines and further comprises a back-flushing cleaning system, and the two centrifugal machines are alternately connected with the plasma collecting system and the back-flushing cleaning system through a first control valve and a second control valve. The centrifugal machine after each round of blood separation is flushed through the backflushing cleaning system, blood residues in a container of the centrifugal machine are avoided, free hemoglobin rising caused by long-time centrifugation of blood components is avoided, and the effect of improving the safety and reliability of the blood purification process is achieved.

The present invention relates to methods of identifying suitable donor blood for cancer patients receiving anti-CD38 antibodies as treatment. In particular, the present invention addresses problems associated with crossmatching patient and donor blood when the patient blood comprises anti-CD38 antibodies that interfere with crossmatching methods of the art.

The invention relates to the field of cell cryopreservation, in particular to a cryopreservation solution combination and a cryopreservation method thereof.The cryopreservation solution combination comprises a cryopreservation solution A and a cryopreservation solution B. The cryopreservation solution A comprises NAD + or precursor molecules thereof or proline; the cryopreservation solution B comprises any one or more of L-carnitine, methyl cellulose, synanthrin, betaine, polyvinyl alcohol (PVA), trehalose or dextran. Meanwhile, the invention provides a cryopreservation method using the cryopreservation liquid combination, the apoptosis phenomenon of cells after resuscitation can be remarkably reduced, the dryness of the cells is maintained, the high activity and high survival rate of the resuscitated cells are ensured, and the cryopreservation liquid combination is particularly suitable for cryopreserved single blood sampling.

The invention belongs to the technical field of medical instruments, and provides a continuous flushing type balloon catheter device, an inner cavity is used for continuous perfusion of heparin water, an outer cavity is used for balloon dilatation to inject liquid or air, the device is stably fixed in a blood vessel through balloon dilatation, continuous perfusion of liquid in the blood vessel is achieved, and the continuous flushing type balloon catheter device is convenient to use. Therefore, the donor keeps the blood vessel (radial artery or superficial temporal artery) to keep certain tension to avoid distortion caused by collapse, continuous perfusion keeps the blood vessel cavity of the donor blood vessel clean and moist, the condition of vascular embolism blockage caused by foreign matters or thrombus in the donor blood vessel is avoided, thrombus formation is fundamentally prevented, and the donor blood vessel is protected from being damaged. Meanwhile, the continuous perfusion can enable the intracranial vascular anastomotic stoma to be in an open state, so that the smooth rate of vascular anastomosis can be kept, the operation area can be kept clean, and the situation that surrounding blood pollutes the anastomotic stoma and affects the smooth rate of the operation is avoided.

The utility model generally relates to the technical field of medical instruments, in particular to a vascular bypass end-side anastomosis deformable supporting device which comprises a main supporting body, an auxiliary supporting body and a connecting piece. The main supporting body is used for being arranged in a receptor blood vessel lumen to expand the vessel wall to assist anastomosis. The auxiliary supporting body is arranged on the main supporting body and used for being placed in a donor blood vessel lumen to expand the vessel wall for end-side anastomosis. The connecting piece is connected to the main supporting body and / or the auxiliary supporting body. The main support body is arranged in the lumen to expand and support the proximal end and the telecentric end of a receptor blood vessel; and expanding and supporting the donor blood vessel through the auxiliary support body, and performing end-side anastomosis. The three-way lumen of a donor blood vessel and a receptor blood vessel is internally supported, anastomotic stoma suturing is completed under supporting, knotting is not performed after two-needle suturing, the supporting body is pulled out from the unknotted opening through the connecting piece, and finally knotting is performed to seal the whole anastomotic stoma. An anastomosis platform with a clear visual field is established for an operator, and the probability of technical errors is reduced.

A method for collecting plasma includes determining the weight, height, and hematocrit of a donor, and calculating a donor plasma volume and a target plasma collection volume. The target plasma collection volume is based on the donor plasma volume and a target percentage of plasma. The method then withdraws blood from the donor through a line connected to a blood component separation device, and introduces anticoagulant into the withdrawn blood. The blood component separation device separates the blood into a plasma component and a second blood component, and the plasma component is collected from the blood component separation device and into a plasma collection container. The method may then calculate the volume of pure plasma collected within the plasma collection container, and continue processing / collecting until the calculated volume of pure plasma equals the target plasma collection volume.

The utility model relates to the technical field of medical instruments, and discloses a blood matching device convenient for tracing, which comprises a base, a plurality of placing units are arranged on the base, each placing unit comprises a label placing box, a donor sample placing part and a patient blood sample placing part, the donor sample placing part is used for storing donor blood samples and donor blood braids, and the patient blood sample placing part is used for storing patient blood samples. A blood matching card placing part and a blood bag placing part are arranged on the base between the donor sample placing part and the patient blood sample placing part, and the label placing box is fixedly connected to the base. According to the technical scheme, the problems of low working efficiency, high management difficulty, easiness in sample loss and the like caused by scattered storage of samples in the existing blood transfusion department work are solved.

The invention discloses a centrifugal belt type blood cell separation detection system and detection method, and belongs to the technical field of blood cell detection.The method comprises the steps that an initial optimal control track is planned and generated according to a state baseline and physiological indexes of a blood donor; tracking an actual separation trajectory, comparing the actual separation trajectory with the initial trajectory, and quantizing to generate a real-time dynamic deviation vector; when the deviation exceeds a dynamic threshold value, performing causal attribution analysis to generate a deviation attribution weight matrix; performing iterative fine tuning on the control instruction according to an attribution result until convergence, and outputting a closed-loop steady-state control flow field to execute compensation; and finally, evaluating and collecting performance, constructing a digital twinning process resume, and feeding back a function mapping relation of an optimization system. According to the method, a cooperative control strategy integrating prediction planning, real-time tracking, causal attribution, dynamic compensation and learning optimization is adopted, and intelligent detection and control of precision, self-adaption and continuous optimization of the blood cell separation process can be achieved.

A method of managing plasma donation throughput of a plasma donor center includes receiving a request message indicating a request from a donor to donate plasma at the plasma donor center. Plasma donor center data is received from two or more of a plasma donor management system, a plasma center queue management system, or a donor plasma donation mobile application. The wait time is determined within the plasma donor center as a function of plasma center data received from at least two of a plasma donor management system, a plasma center queue management system, or a donor plasma donation mobile application. A reservation message is forwarded to a blood establishment computer system regarding the queue position of the donor, the reservation, or both the donor and the reservation, and a confirmation message is forwarded toward including the determined wait time and preferred arrival time for the donor.

The invention provides a blood purification treatment system, and belongs to the technical field of medical equipment. Comprising a plasma collection system, a plasma adsorption system and a liquid feedback system which are connected with a blood supplier to form a blood closed-loop conveying loop, the plasma collection system comprises a blood collection tube, the blood collection tube is connected with centrifugal machines through two blood collection branch tubes, and the outlet ends of the two centrifugal machines are jointly connected with a first plasma bag; the two blood collection branch pipes are connected with a blood collection system and connected with a blood collection adsorption system through a first blood collection bag, blood collection pumps are arranged on the two blood collection branch pipes, the blood collection branch pipes are connected with first back-transfusion branch pipes, and the two first back-transfusion branch pipes are combined and then connected with a liquid back-transfusion system. The electric valve assembly is used for controlling only one of the two blood sampling branch pipes to be opened at the same time and controlling the first feedback branch pipe and the blood sampling branch pipe to be opened and closed in opposite states. In the process of pumping blood to one centrifugal machine and centrifugally separating blood plasma on line, red blood cells in the other centrifugal machine are transfused back to the human body, and the effects of continuously keeping blood sampling and liquid transfusing back and improving the blood sampling efficiency are achieved.

A system and method of transfusing blood from a donor source to a patient. To facilitate the transfusion, a transfer tube is provided. One end of the transfer tube is connected to the donor source and the opposite end is intravenously connected to the patient. A pump assembly is provided that contains a pump and a microprocessor. The transfer tube is engaged with the pump assembly wherein the pump, when activated, acts upon the transfer tube to move blood. The microprocessor monitors the blood volume moved and automatically stops the pump once a predetermined volume of blood has been transferred. If the donor source is a person, the predetermined volume is between 400 milliliters and 450 milliliters. The flow rate of the pump is preferably 100 milliliters per minute.

The present invention provides for recombinant antibodies which bind to RhD blood group antigens as well as compositions comprises these recombinant antibodies and methods for selecting a combination of different recombinant antibodies derived from donor blood. The recombinant antibodies are useful for the treatment of the prevention of haemolytic disease of the newborn (HDN), treatment of idiopathic thrombocytopenic purpura (ITP), and to impede anti-RhD alloimmunisation in RhD negative patients who receive an RhD+ blood transfusion.

The present invention relates to methods of identifying suitable donor blood for cancer patients receiving anti-CD38 antibodies as treatment. In particular, the present invention addresses problems associated with crossmatching patient and donor blood when the patient blood comprises anti-CD38 antibodies that interfere with crossmatching methods of the art.

The application provides a preparation method of a general CAR-T feeder cell, and is used for preparing a feeder cell of a CAR-T cell aiming at a target antigen, and has the characteristics that the method comprises the following steps: an erythroblast obtaining step, single nuclear cells are separated from donor blood, and are induced and differentiated to obtain erythroblasts; a vector obtaining step, a lentivirus vector at least expressing a target antigen is constructed, and a recombinant virus supernatant of the lentivirus vector is prepared; a transfection step, the recombinant virus supernatant is used for transfecting the erythroblasts; an amplification step, the transfected erythroblasts are amplified to obtain amplified erythroblasts; and an irradiation treatment step, the amplified erythroblasts are subjected to irradiation treatment to obtain the feeder cell. The feeder cell prepared by the method can promote antigen-dependent specific activation and amplification of the CAR-T cell aiming at the target antigen, can reduce the preparation difficulty and cost of the feeder cell, and can realize the generalization of the feeder cell.

The present invention provides recombinant antibodies that bind to RhD blood group antigens as well as compositions comprising these recombinant antibodies and methods for selecting combinations of different recombinant antibodies derived from donor blood. The recombinant antibodies are useful in the prevention of neonatal hemolytic disease (HDN), the treatment of idiopathic thrombocytopenic purpura (ITP), and the prevention of anti-RhD alloimmunity in RhD negative patients receiving RhD + transfusion.

The present disclosure provides methods for identifying a human donor or a donor blood sample that is suitable for obtaining a population of Vδ1+ gamma delta (γδ) T cells, the method comprising assaying for the presence of naïve Vδ1+ γδ T cells in the donor blood sample by detecting the presence of cells that express CD27, CD127, CD73, or any combination thereof. Further provided are populations of γδ T cells obtained from the suitable donor blood sample and methods of using the same.

The present invention relates to a method for identifying donor blood suitable for cancer patients receiving anti-CD38 antibodies as treatment. [Solution] In particular, the present invention addresses problems related to cross-matching tests between patient blood and donor blood when the patient blood contains anti-CD38 antibodies that interfere with cross-matching methods of the art.