44 results about "Donors blood" patented technology

Described herein is a method and apparatus for collecting and separating whole blood into its components, including collecting an amount of plasma and red blood cells. The collection and separation system includes a console and a disposable set. The method may include processing the blood through the centrifuge, collecting plasma, collecting red blood cells and returning red blood cells until a desired plasma volume is reached. Then a final volume of red blood cells and plasma may be collected. The disposable set may include a manifold, a CFC, and various components attached by tubing. These components may include one or more solution bags, blood product bags, bacterial filters, leukofilters, and a donor blood collection tube with access needle.

An apparatus and a method whereby plasma integrity of plasma contained in a blood bag is rapidly and accurately assessed without compromising the sterility of the plasma, or destroying any of its components. This is achieved through spectral data which is used in a novel way so as to determine if a plasma specimen representative of plasma in a blood bag contains interferents and if so, to what extent. The apparatus and method analyse plasma contained in two bags whereby tubing connects the two bags. A lamp is used to irradiate the specimen, and a spectrophotometer is used to measure radiation from the specimen. The apparatus and method allow for determination where both the bags and tubings are translucent and contain writing on their surfaces (e.g., proprietary information), and the light is transmitted through the writings, plastic, and the plasma contained in the bag or tubing.

Described herein is a method and apparatus for collecting and separating whole blood into its components, including collecting an amount of plasma. The collection and separation system includes a console and a disposable set. The method may include processing the blood through the centrifuge, collecting the plasma, and returning red blood cells remaining in the centrifuge to the source. The disposable set may include a manifold, a CFC, and various components attached by tubing. These components may include one or more solution bags, blood product bags, bacterial filters, leukofilters, and a donor blood collection tube with access needle.

An apparatus and a method whereby plasma integrity of plasma contained in a blood bag is rapidly and accurately assessed without compromising the sterility of the plasma, or destroying any of its components. This is achieved through spectral data which is used in a novel way so as to determine if a plasma specimen representative of plasma in a blood bag contains interferents and if so, to what extent. The apparatus and method analyse plasma contained in two bags whereby tubing connects the two bags. A lamp is used to irradiate the specimen, and a spectrophotometer is used to measure radiation from the specimen. The apparatus and method allow for determination where both the bags and tubings are translucent and contain writing on their surfaces (e.g., proprietary information), and the light is transmitted through the writings, plastic, and the plasma contained in the bag or tubing.

The systems and methods for pathogen reduction in donor blood operates by exposure of blood to UVC irradiation. Unwanted wavelengths of light, mostly in the infrared spectra, may be precluded from reaching blood by providing a layer of IR-absorbing fluid positioned between blood and the source of UV irradiation, whereby minimizing energy absorption and heating of blood. Some embodiments further disclose a system configured to utilize the same IR-absorbing fluid to actively cool blood by flowing along the flow path thereof.

Described herein is a continuous-flow centrifuge (CFC) which may be embodied in an automated system for collecting and separating whole blood into its components. The collection and separation system includes a console and a disposable set. Various blood processing procedures which produce specific blood products may be implemented by using a specific disposable set for each process. The disposable set may include a manifold, a CFC, and various components attached by tubing. These components may include one or more solution bags, blood product bags, bacterial filters, leukofilters, and a donor blood collection tube with access needle. The manifold and CFC disk may be included in a cassette that mounts onto the front panel of the console. The console may contain valve actuators, pressure transducers, ultrasonic sensors, a roller pump assembly, a CFC drive system, optical sensors, electronics, software, user interface components, a bar code reader and data acquisition components.

Described herein is a continuous-flow centrifuge (CFC) which may be embodied in an automated system for collecting and separating whole blood into its components. The collection and separation system includes a console and a disposable set. Various blood processing procedures which produce specific blood products may be implemented by using a specific disposable set for each process. The disposable set may include a manifold, a CFC, and various components attached by tubing. These components may include one or more solution bags, blood product bags, bacterial filters, leukofilters, and a donor blood collection tube with access needle. The manifold and CFC disk may be included in a cassette that mounts onto the front panel of the console. The console may contain valve actuators, pressure transducers, ultrasonic sensors, a roller pump assembly, a CFC drive system, optical sensors, electronics, software, user interface components, a bar code reader and data acquisition components.

An in vitro method that allows detection of hepatitis C by detecting hepatitis C virus (HCV) core protein and antibodies to HCV core protein (anti-core antibodies) in a single assay is provided. Cross-reactivity is eliminated in the method preferably by utilizing short peptides, each of which has an amino acid sequence that corresponds to an immunodominant region of the native core protein but which does not wholly encompass the epitope bound by the antibodies utilized in the method. The method can be used to detect the presence of HCV in a subject, and/or to determine the suitability of donor blood or blood products for transfusion purposes. Also provided are diagnostic kits for carrying out the method and a process for selecting suitable capture peptides and monoclonal antibodies for use in the combination method.

Methods and apparatus are provided for forming a vascular graft in vitro by axially distending a blood vessel to induce growth. The apparatus comprises a chamber containing a tissue culture medium, an inlet cannula, an outlet cannula, and a means for moving the inlet cannula, the outlet cannula, or both, to axially stretch a donor blood vessel secured between the inlet cannula and the outlet cannula in a submerged position in the tissue culture medium, wherein the inlet cannula, the outlet cannula, and the donor blood vessel are secured together to form a conduit through which the tissue culture medium can flow.

The invention discloses a portable organ donation donor mechanical perfusion system. The portable organ donation donor mechanical perfusion system comprises a blood circulation oxygenation closure device and a control device electrically connected with the blood circulation oxygenation closure device; the blood circulation oxygenation closure device comprises an oxygenator, a centrifugal pump, a blood exchanger, an arterial cannula, and a venous cannula; the blood exchanger is internally provided with a piston capable of moving vertically, the upper part of the piston is a first storage end for storing donor blood, the lower part of the piston is a second storage end for storing perfusion liquid, a blood input end and the output end of the centrifugal pump are communicated with the first storage end through a first three-way valve, and the blood input end and the output end of the centrifugal pump are communicated with the second storage end through a second three-way valve, so that low-temperature perfusion can be completed without cannulation in the abdominal aorta after laparotomy. Moreover, since a balloon is arranged at the tip end of the arterial cannula, only the balloon isneeded to be inflated or injected with water when only an abdominal organ is perfused, and convenience is realized.

The invention relates to a method for the inactivation of pathogens such as bacteria and viruses in donor blood, blood plasma and erythrocyte concentrates by photodynamic treatment and/or irradiation with ultraviolet light in flexible irradiation bags under intense movement.

Transplant of donor perfectly matched HLA hematopoietic stem cell to cure Sickle cell anemia and other anemia such as leukemia. Sterilized In vivo transplantation of clinically adequate quantities of antibiotic protected HLA vector/or insertion corrected chimera stem cells, and switching protein. Stem cells can be transfected for Hbg SS, and other proteins such as minor HLA type that may cause Graft versus host disease (GvHD) or Host versus Graft disease (HvGD Universal donor blood, Rh-negative of any HLA type can be corrected to perfectly match that of any recipient. Batch universal stem calls are grown and selectively transformed to a chimera stem cell. The chimera stem cells are incubated in a bio-reactor in growth medium also containing human growth and maturation promotion polypeptide factors. The harvest is then prepared for clinical use and transplantation into the matching recipient. Recipient's stem cells are transformed by transfection or insertion of the beta hemoglobin gene.

The invention relates to the technical field of medical equipment, and in particular relates to an isolated organ storage system, which comprises a donor blood collection device, a complementary-pull type antiphase beating pump, a first roller single pump, an oxygenator, an isolated organ thermal insulation device, a blood heating device, an oxygen supply device, a filter, a waste liquid bag, an urine collection device, and a bile collection device. The isolated organ storage system of the invention is based on a novel blood pump (i.e. complementary-pull type antiphase beating pump), and integrates the membrane type oxygenator, the filter, the roller single pump and necessary monitoring sensors. The invention provides a pseudo-ecological isolated organ storage method and storage system. To this end, the invention in particular provides the corresponding isolated organ obtaining method and the thermal insulation and heating device. The invention aims to maximally prolong the storage time of isolated organs (liver, kidney) to facilitate the transportation and repair, thereby improving transplantation success rate and receptor survival rate.

The invention relates to a granulocyte separating and purifying method, and especially relates to a novel granulocyte preparation method without damaging the activity of granulocytes, and a cancer-killing assay (CKA) method of the granulocytes. The CKA method comprises the following steps: 1, acquiring 2ml of the peripheral blood of a blood donor, and carrying out heparin anticoagulation; 2, mixing the blood with a precipitation liquid prepared through using a precipitation liquid (LIFT-001) formula developed by the applicant according to a volume ratio of the blood to the precipitation liquid of 5:1; 3, transferring the supernatant of a mixture obtained in step 2 to a centrifuge tube added with LIFT-002, centrifuging, and taking a buffy coat; 4, adding a culture medium, and counting for obtaining effector cells; incubating the effector cells and target cells; and 5, carrying out CKA detection. CKA experiment results show that the granulocytes of some healthy adults can effectively kill Hela tumor cells. Cell real-time monitoring system results show that cancer cells are broken and killed by the granulocytes. Cancer killing activity assay allows efficient donors having high activities to be screened, and can be used for the cancer prevention and treatment, and the management of dangerous factors.

The method employs a commercially-available blood cell separator comprising a computer-controlled centrifuge (2) having a rotor into which a blood processing bag (6) containing donor blood is placed. Once the blood is collected, the process is performed entirely within the enclosed centrifuge bowl, preferably in situation at the donor collection site. In the first step, the blood is centrifuged to separate the plasma from the cellular components. After isolation of the red blood cells from other blood components, the red cells are washed with normal saline or other solution. The red blood cells are then lysed by hypotonic shock to separate the red cell membranes (stroma) and the lysate is collected in a sterile container (44), leaving only the stroma in the centrifuge bowl. The final product can be used as raw material for any of the hemoglobin-based oxygen carriers currently being developed as red cell substitutes. All of the steps are performed within a processing container or blood bag (6) in the bowl centrifuge to minimize handling and maintain sterility. A method for preparing a modified hemoglobin solution incorporates the steps for producing stroma-free hemoglobin, then adding pre-measured reagents to react with the solution and filtering the solution.

The invention discloses a blood transfusion management method including: scanning patient information and information of a blood donor on a blood preparation into a patient information database of a hospital; primarily checking the patient information before collecting a blood sample of a patient; secondarily checking the patient information before a blood bank detects the blood sample; and tertiarily checking the patient information before the patient is in blood transfusion. By the blood transfusion management method, an electronic identifier is used for respectively checking the patient information in a blood collection phase, a blood bank blood detection phase and a blood transfusion phase, so that blood transfusion management level in hospitals is improved, and various errors possibly caused during blood management are reduced.

The invention discloses a colloidal gold immunochromatography trace whole blood detection test paper and a detection method thereof. A sample is added at the front end and is different from a traditional back-end sample adding technology, meanwhile, a trace whole blood filter membrane is additionally arranged on a front-end nitrocellulose membrane, and after the trace whole blood is added, the trace whole blood passes through the treated whole blood filter membrane, serum permeates into the nitrocellulose membrane, red blood cells and the like are retained on the whole blood filter membrane, and the effect of rapidly separating the red blood cells is achieved. The application range and the detection effect of the trace whole blood are widened, and meanwhile the test paper can also be used for serum and plasma; and according to the method, peripheral blood collection is very easy, trauma is small, experience of a blood supplier is also easy, the detection method is simple, convenient and rapid, and results are accurate and reliable.

The invention discloses an intelligent biological recognition automatic blood sampling system combined with the network technology. The system comprises an intelligent biological recognition apparatusand an automatic blood sampling apparatus, wherein the intelligent biological recognition apparatus comprises a camera, a biological radio frequency sensor, a Type B non-contact IC card reader, an information digital memory and a bar code printer, the camera, the biological radio frequency sensor and the Type B non-contact IC card reader collect identity information and store the identity information into the digital memory, and the bar code printer is used for printing a blood sampling card with the identity information; and the automatic blood sampling apparatus comprises a full-automatic blood sampling arm, a blood sampling needle telescopic cylinder, a blood sampling needle clamping apparatus, a blood sampling needle storage bin automatic feeding apparatus, a blood sampling card clamping apparatus, a blood sampling card storage apparatus, a blood sampling auxiliary apparatus, a motor and a control apparatus. According to the system, the accuracy of the identity information of a detected person is guaranteed, the workload and occupational exposure risks of medical staff are reduced, a non-contact blood sampling self-service mode between blood sampling and supplying persons is provided, and a large-scale intelligent medical treatment and DNA database can be constructed.

The invention discloses a blood bag information processing method. The method comprises the following steps: receiving blood supplier information and blood information of a to-be-processed blood bag;determining printing code label information according to the blood supplier information and the blood information; and sending the printing code label information to a printer, so that the printer prints a corresponding printing code on the to-be-processed blood bag according to the printing code label information. According to the method, subsequent information storage and reading are facilitated, the printed code directly printed on the blood bag cannot fall off or be damaged due to the fact that blood encounters water in the repeated freezing and unfreezing process, meanwhile, the printed code is scanned through a subsequent scanner to obtain related blood information, digital management of the blood is also facilitated, long-term storage of the blood bag information is ensured, the management of the blood bag information is facilitated, and the blood bag storage cost is reduced. The invention further provides a blood bag information processing device and equipment with the beneficial effects and a computer readable storage medium.

A blood component sampling cassette which can be more efficiently manufactured at lower cost as compared to a typical cassette, a blood sampling circuit set, and a blood component sampling system. A blood component sampling cassette (22) includes a cassette main body (23) made of a soft material to which heat sterilization is applicable. The cassette main body (23) is provided with a retransfusionline (44). The retransfusion line (44) is provided with a reservoir (47) configured to temporarily store a blood component to be returned to a blood donor. The reservoir (47) is pressed by a retransfusion pump (49) to discharge the blood component from the reservoir (47).

The invention discloses a test device for cross-matching blood. Existing blood test and blood matching equipment are all large-scale equipment, which will only be used when the amount of experiments is large. The invention includes a freezer body and a test part. A test area is arranged in the freezer body. The upper layer board and the lower layer board arranged at intervals up and down are fixed in the test area. The upper layer board and the lower layer board divide the test area into a blood sample storage chamber, a reagent storage chamber and a test body chamber arranged in sequence from top to bottom. The test part includes a lifting and retrieving mechanism, a blood sample access mechanism, a reagent adding mechanism, a blood collection centrifuge module and a camera. The blood collection centrifugation module includes a sampling mechanical arm, a blood recipient blood sample storage plate, a blood centrifugation mechanism, a needle storage mechanism and an empty test tube storage rack. The invention can automatically detect the blood type of the blood of the blood recipient, and select the blood of the blood donor of the same blood type to perform a cross-matching test, thereby automatically determining a suitable blood donor and sending out a usable blood bag.

The embodiment of the invention provides a method and device for matching a blood donor for a blood receiver. The method comprises the steps: according to first antigen information of a blood receiver, judging whether a blood donor meeting a first condition exists or not , wherein the first condition is that all antigens contained in the first antigen information of the blood donor are contained in the first antigen information of the blood receiver, and the first antigen information is antigen information corresponding to irregular antibodies; if yes, determining the blood donor meeting the first condition as a matched blood donor of the blood receiver; if the first antigen information does not exist, judging whether a blood donor meeting a second condition exists, wherein the second condition is that in all antigens contained in the first antigen information of the blood donor, only one antigen is not contained in the first antigen information of the blood receiver; and if yes, determining the blood donor meeting the second condition as a matched blood donor of the blood receiver. By means of the method, the occurrence rate of adverse reactions of the blood receiver in subsequent blood transfusion can be reduced.