The invention relates to the technical field of medical supply manufacturing tools, and relates to an antibiotic bone cement prefabricated mesh plate, an antibiotic bone cement steel plate and a manufacturing frame of the steel plate. The antibiotic bone cement prefabricated mesh plate comprises a mesh plate body, the mesh plate body is in a strip shape, and the mesh plate body comprises a plurality of mesh layers which are stacked and distributed from top to bottom. The antibiotic bone cement steel plate comprises an antibiotic bone cement plate body and the antibiotic bone cement prefabricated mesh plate. The manufacturing frame comprises a base, a pressing plate, a gasket, a limiting screw, a suspension cross beam, a connecting plate and a lifting rod; the base comprises a left verticalplate, a lower transverse plate and a right vertical plate, and the left end and the right end of the lower transverse plate are fixed together with the lower ends of the left and right vertical plates respectively. The antibiotic bone cement steel plate can be manufactured more conveniently, the antibiotic bone cement steel plate can reduce the frequency of debridement of infected bones and softtissue treatment, the length of stay and time in bed can be shortened for patients, and the situation that due to local bone infection and bone ununion, operations are needed again and accordingly extra medical cost is increased for the patients is avoided.