The invention discloses a
cone beam CT image
reconstruction method and device, equipment and a storage medium. The method comprises the following steps: acquiring
limited angle projection data and geometric parameters; inputting the three-dimensional
Gaussian kernel parameter into a pre-trained
generative model to obtain an initial
Gaussian kernel parameter of the three-dimensional
Gaussian scene; taking the initial scene as a starting point, carrying out iterative optimization under the constraint of a micro-
cone beam CT forward
projection model, obtaining a
synthetic projection through micro-rendering in each iteration, calculating an error between the
synthetic projection and a real projection, updating Gaussian kernel parameters according to the error, and adaptively adjusting the
density distribution of Gaussian kernels; and finally, converting the optimized scene into three-dimensional volume data and outputting the three-dimensional volume data. According to the method, strong structure prior initialization is provided through the
generative model, and high-quality and high-efficiency reconstruction under the condition of serious data missing is realized in combination with iterative optimization constrained by the
physical model and adaptive structure adjustment, so that artifacts are remarkably inhibited, and a clear anatomical structure is recovered.