Compounds represented by the following structure (I) are disclosed:as are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first
aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second
aldehyde to produce the class of compounds with the generic structure, where the first
aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a
benzaldehyde, imidazolecarboxaldehyde derivatives, and
benzaldehyde derivatives, thereby forming the above compound wherein R1, R1′, R1″, R2, R3, R4, R5, and R6, X1 and X2, Y, Z, Z1, Z2, Z3, and Z4 may each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating
cancer and fungal infection are also disclosed.