34results about How to "Comply with economical synthesis" patented technology

The invention discloses a method for preparing boric acid ester based on anilinolithium compound. Stir and mix the catalyst, borane and aromatic carboxylic acid in sequence, react for 35 to 45 minutes, expose to the air to terminate the reaction, remove the solvent from the reaction liquid under reduced pressure, and obtain boric acid esters with different substituents. The anilinolithium compound disclosed by the present invention can catalyze the hydroboration reaction of carboxylic acid and borane with high activity at room temperature, and the catalyst consumption is only 0.8mol% of the molar weight of carboxylic acid. Compared with the existing catalytic system, the use of The commercial reagent anilinolithium compound was discovered, the reaction conditions were mild, and the yield of borate esters with different substituents could reach 99% under limited conditions.

The invention relates to a method for preparing aliphatic alcohol at room temperature. The catalyst, borane and carboxylic acid are stirred and mixed in sequence, reacted for 50 to 60 minutes, exposed to the air to terminate the reaction, the reaction solution is decompressed to remove the solvent, and silica gel and methanol are added. , carry out the hydrolysis reaction to obtain aliphatic alcohols with different substituents. The anilinolithium compound disclosed in the present invention can catalyze the hydroboration reaction of carboxylic acid and borane with high activity at room temperature, and the amount of catalyst is only 0.6 mol% of the molar amount of carboxylic acid. Compared with the existing catalytic system, the use of A commercial reagent anilinolithium compound is developed, the reaction conditions are mild, and the yields of aliphatic alcohols with different substituents are high under limited conditions.

The invention relates to an application of n-butyllithium in catalysis of a hydroboration reaction of aliphatic carboxylic acid and borane. A catalyst, the borane and the carboxylic acid are uniformlystirred and mixed, and reacted for 10-20 minutes, the reaction is terminated by exposing in air, and a solvent is removed through vacuum distillation of the reaction solution to obtain borate with different substituent groups. The n-butyllithium disclosed by the invention can catalyze the hydroboration reaction of carboxylic acid and borane with high activity at room temperature, and the catalystadopted is 0.2 mol% of the carboxylic acid. Compared with the existing catalytic system, the commercial reagent n-butyllithium has advantages of mild reaction condition is mild and capability of enabling the yield of borate with different substituent groups to reach 99% under the limited condition.

The present invention relates to the application of 2,6-diisopropylanilinide lithium, in particular to the application of 2,6-diisopropylanilide lithium in catalyzing the hydroboration reaction of imine and borane. Stir and mix the catalyst, borane and imine in sequence, react for 1 to 2 hours, and expose to the air to terminate the reaction, remove the solvent from the reaction solution under reduced pressure, and obtain boric acid esters with different substituents. The 2,6-diisopropylanilinolithium disclosed by the present invention can catalyze the hydroboration reaction of imine and borane with high activity at room temperature, and the amount of catalyst is only 4~5 mol% of the molar weight of imine. It can reach a yield of more than 90%. Compared with the existing catalytic system, the simple 2,6-diisopropylanilinide lithium is used, and the reaction conditions are mild. Under optimized conditions, the borates of different substituents can The yield can reach 99%.

The invention relates to an application of an anilino lithium compound, in particular to a method for preparing an alcoholic compound from the anilino lithium compound as a catalyst. The catalyst, borane and carboxylic acid are stirred and mixed uniformly, subjected to a reaction and exposed to air to terminate the reaction, a reacted liquid is subjected to reduced-pressure treatment for solvent removal, silica gel and methanol are added, and the alcoholic compound is obtained by hydrolysis. The anilino lithium compound can perform high-activity catalysis on the reaction between carboxylic acid and borane at room temperature, dose of the catalyst is only 0.8mol% of the mole ratio of carboxylic acid, compared with the conventional catalysis system, the commercial reagent anilino lithium compound is used, reaction conditions are mild, and yield of borate with different substituents under limit conditions can reach 90% or higher.

The invention relates to application of 2,6-lithium dimethyl aniline, and particularly relates to the application of the 2,6-lithium dimethyl aniline to catalyzing hydroboration of imine and borane. Acatalyst, the borane and the imine are sequentially evenly mixed, reacted for 1-2 hours, and exposed in the air to terminate the reaction, a reaction liquid is decompressed to remove a solvent, and borate having different substituent groups is obtained. The disclosed 2,6-lithium dimethyl aniline can catalyze the hydroboration of the imine and the borane at high activity under the condition of room temperature, the use level of the catalyst is only 4-5 mol% of the molar weight of the imine, the reaction reaches the yield of more than 90%, compared with the existing catalysis system, the simple2,6-lithium dimethyl aniline is used, the reaction condition is mild, and the yield of the borate having different substituent groups is up to 99% under the optimized condition.

The present invention relates to the application of n-butyllithium, in particular to a method for preparing alcohol compounds based on n-butyllithium aromatic carboxylic acid, in which the catalyst, borane and carboxylic acid are stirred and mixed in sequence, and after the reaction, they are exposed to the air to terminate the reaction. The solvent was removed from the reaction solution under reduced pressure, and then silica gel was added for methanol hydrolysis to obtain the alcohol compound. The n-butyllithium disclosed by the present invention can catalyze the hydroboration reaction of carboxylic acid and borane with high activity at room temperature, and the amount of catalyst is only 0.5mol% of the molar weight of carboxylic acid. Compared with the existing catalytic system, the use of The commercial reagent n-butyllithium was discovered, the reaction conditions were mild, and the yield of borate esters with different substituents could reach more than 90% under limited conditions.

The invention relates to an application of 4-methoxyaniline lithium, and concretely relates to an application of 4-methoxyaniline lithium in the catalysis of a hydroboration reaction of imine and borane. A catalyst, borane and imine are stirred and mixed uniformly, the obtained mixture is reacted for 1-2 h, and is exposed to air to terminate the reaction, and the obtained reaction solution undergoes reduced pressure solvent removal to obtain borate with different substituent groups. The 4-methoxyaniline lithium can highly actively catalyze the hydroboration reaction of imine and borane at roomtemperature, the use amount of the catalyst is only 4-5% of the molar quantity of the imine, and the reaction yield can reach 90% or above. Compared with existing catalysis systems, the system in theinvention, using the simple 4-methoxyaniline lithium, has mild reaction conditions, and allows the yield of the borate with different substituent groups under optimized conditions to reach 99%.

The invention relates to an application of p-methylaniline lithium, and concretely relates to an application of p-methylaniline lithium in the catalysis of a hydroboration reaction of imine and borane. A catalyst, borane and imine are stirred and mixed uniformly, the obtained mixture is reacted for 1-2 h, and is exposed to air to terminate the reaction, and the obtained reaction solution undergoesreduced pressure solvent removal to obtain borate with different substituent groups. The p-methylaniline lithium can highly actively catalyze the hydroboration reaction of imine and borane at room temperature, the use amount of the catalyst is only 4-5% of the molar quantity of the imine, and the reaction yield can reach 90% or above. Compared with existing catalysis systems, the system in the invention, using the p-methylaniline lithium, has mild reaction conditions, and allows the yield of the borate with different substituent groups under optimized conditions to reach 99%.

The invention relates to application of n-butyl lithium, in particular to a method for preparing boric acid ester based on the n-butyl lithium. The method comprises the following steps: sequentially stirring a catalyst, borane and carboxylic acid, uniformly mixing and reacting for 40 to 50 minutes; exposing to the air for termination reaction; depressurizing reaction liquid and removing a solventto obtain the boric acid ester with different substituent groups. The n-butyl lithium disclosed by the invention can realize high-activity catalysis of hydroboration of carboxylic acid and borane at room temperature; the use amount of the catalyst is only 0.5 mol percent of the molar amount of carboxylic acid. Compared with an existing catalytic system, the boric acid ester utilizes a commercial reagent n-butyl lithium, and reaction conditions are mild; the yield of the boric acid ester with different substituent groups reaches 99 percent under limited conditions.

The invention relates to an application of n-butyllithium in catalysis of a hydroboration reaction of aliphatic carboxylic acid and borane. A catalyst, the borane and the carboxylic acid are uniformlystirred and mixed, and reacted for 10-20 minutes, the reaction is terminated by exposing in air, and a solvent is removed through vacuum distillation of the reaction solution to obtain borate with different substituent groups. The n-butyllithium disclosed by the invention can catalyze the hydroboration reaction of carboxylic acid and borane with high activity at room temperature, and the catalystadopted is 0.2 mol% of the carboxylic acid. Compared with the existing catalytic system, the commercial reagent n-butyllithium has advantages of mild reaction condition is mild and capability of enabling the yield of borate with different substituent groups to reach 99% under the limited condition.

The invention discloses application of a trisilazane-rare earth complex in catalysis of hydroboration reaction between aldehyde and borane. The trisilazane-rare earth complex disclosed by the invention can be used for catalyzing the hydroboration reaction between aldehyde and borane in a high activity manner under a mild condition (room temperature), and the dosage of a catalyst is only 0.1%-0.5% of molar ratio of aldehyde; the reaction speed is very high, the yield higher than 90% can be achieved after 10 minutes of reaction; compared with existing catalytic systems, the application has the advantages that the dosage of the catalyst is reduced, the yield is increased, the required time is short, the reaction condition is mild, and atom economy synthesis is highly met.

The invention relates to the application of n-butyllithium, in particular to the application of n-butyllithium in catalyzing the hydroboration reaction of imine and borane. Stir and mix the catalyst, borane and imine in sequence, react for 1 to 2 hours, and expose to the air to terminate the reaction, remove the solvent from the reaction solution under reduced pressure, and obtain boric acid esters with different substituents. The n-butyllithium disclosed by the present invention can catalyze the hydroboration reaction of imine and borane with high activity at room temperature, the amount of catalyst is only 4-5 mol% of the molar weight of imine, and the reaction can reach a yield of more than 90%. , compared with the existing catalytic system, the commercial reagent n-butyllithium is used, the reaction conditions are mild, and the yield of borate esters with different substituents can reach 99% under limited conditions.

The present invention relates to the application of anilinolithium, in particular to the application of anilinolithium in catalyzing the hydroboration reaction of imine and borane. Stir and mix the catalyst, borane and imine in sequence, react for 1 to 2 hours, and expose to the air to terminate the reaction, remove the solvent from the reaction solution under reduced pressure, and obtain boric acid esters with different substituents. The anilinolithium disclosed in the present invention can catalyze the hydroboration reaction of imine and borane with high activity at room temperature, the amount of catalyst is only 4-5 mol% of the molar weight of imine, and the reaction can reach a yield of more than 90%. , compared with the existing catalytic system, the simple anilinolithium is used, the reaction conditions are mild, and the yield of borate esters with different substituents can reach 99% under optimized conditions.

The invention relates to a method for preparing a phosphine guanidine compound. The method comprises steps as follows: under water-free and oxygen-free conditions and under nitrogen protection, diphenylphosphine, a disilylamine rare earth complex and carbodiimide are mixed uniformly in sequence to react to obtain the phosphine guanidine compound. The disilylamine rare earth complex is obtained bycatalyzing a phosphine hydrogenation reaction of carbodiimide and diphenylphosphine in a high-activity manner under the mild condition (room temperature), and the dosage of a catalyst is only 0.1%-0.5% of the molar weight of carbodiimide; the reaction speed is very high, and the yield of 95% or above can be obtained after 60 min of reaction; Compared with existing catalysis systems, the dosage ofthe catalyst is reduced, the yield is increased, short time is required, the reaction conditions are mild, and atom economy synthesis is highly met.

The invention discloses the application of a trisilicon amine rare earth complex in catalyzing the hydroboration reaction of ketones and boranes. base ketones. The trisilicon amine rare earth complex disclosed by the present invention can catalyze the hydroboration reaction of ketone and borane with high activity under mild conditions (room temperature), and the amount of catalyst only needs 0.1-0.5% of the molar amount of ketone; the reaction speed is very fast, and the reaction The yield of more than 90% can be reached in 10 minutes. Compared with the existing catalytic system, it not only reduces the amount of catalyst used, but also increases the yield. The required time is short, the reaction conditions are mild, and it is highly in line with atom-economical synthesis.