The invention discloses an unlocking method of a Bluetooth-based safety intelligent lock system with a video monitoring function. The safety intelligent lock system comprises an intelligent lock, a mobile terminal and a master station, wherein the intelligent lock is provided with an MCU (micro control unit) control module and a video module; a software operation module is installed on the mobile terminal; the intelligent lock is connected with the mobile terminal through communication via a Bluetooth; the mobile terminal is connected with the master station through communication. The unlocking method has the advantages that safe unlocking of the intelligent lock is achieved through command sending of the mobile terminal, verification of secret keys or information among the intelligent lock, the mobile terminal and the master station and image acquisition verification of the intelligent lock; the lock system is intelligent, is convenient to operate and is safe and reliable; meanwhile, as the functions of overall planning management and information storage of a communication network and the master station are adopted, the information, such as operation objects, operating personnel, object states, operation time, and the like of unlocking and locking, can be effectively recorded and managed; the software part of the lock system is updated and upgraded to increase the safety level; the lock system has strong adaptability and adjustability; effective management of the lock system is perfected.