Biologically induced composite artificial esophagus

Abstract

The invention relates to a biologically induced composite artificial esophagus. A film-coated elastic supporting tube with a connector is used, an absorbable coating can be attached to the outer wall of the supporting tube, and the absorbable coating contains growth factors. The connector can effectively reduce the effect of the esophageal peristalsis on the body of the implanted elastic supporting tube, and the supporting tube has good flexibility and strong supporting force, thus, the artificial esophagus can prevent anastomotic fistula, early decannulation and neonatal oesophagostenosis. The absorbable coating containing growth factors, attached to the elastic support pipe, can induce or promote the growth or coverage of the mucous membrane of the neonatal esophagus. After the complete coverage of the mucous membrane of the neonatal esophagus and the stabilization of the scar tissues of the neonatal esophagus, the implanted artificial esophagus is taken out or removed under the direct view of the digestive endoscopy.

Description

technical field [0001] The invention relates to an esophageal substitute, in particular to an artificial esophagus used for esophageal reconstruction. Background technique [0002] Esophageal cancer is a common disease in China. It ranks second in the incidence rate of common malignant tumors. The incidence rate is 21 / 100,000, that is, more than 273,000 new patients are added every year. Moreover, the current incidence rate is still on the rise, causing great harm. . At the same time, esophageal injuries caused by various reasons, especially those caused by car accidents, are also on the rise. How to implement esophageal reconstruction effectively is the key to reduce mortality and improve patients' quality of life. [0003] The lesions of esophageal cancer usually have the characteristics of multi-center jumping. So far, the most effective treatment for esophageal cancer is still to use surgical resection of the diseased esophagus, and at the same time, use substitutes to...

AI Technical Summary

Problems solved by technology

[0005] At present, clinically, other tissues or organs of the patient are mainly used to restore and reconstruct the esophageal passage, such as lifting the stomach or intestines from the abdominal cavity to the chest cavity or anastomosis of the neck with the retained normal esophageal stump to restore and reconstruct the esophageal passage. The traditional surgical method has the following disadvantages: large surgical trauma, long time, shift of organ anatomical position, affecting cardiopulmonary function and digestive dysfunction, etc.

[0010] Since Berman et al. took the lead in replacing esophageal defects with special polyethylene tubes in 1953, silicone rubber, Dacron, Teflon, carbon fiber, and various metal materials have been used successively for research and manufacture. Artificial esophagus, but failed to achieve the desired effect

In 1991, Purushotham et al. conducted research on the application of absorbable acellular scaffold materials to manufacture artificial esophagus. The method was to use biodegradable materials and non-degradable polymer materials to form a complex, and to perform esophageal reconstruction by inducing recipient esophageal tissue regeneration. Although Satisfactory results have been obtained in animal experiments, but there are also many defects. Such experimental methods are only applicable to a short range of esophageal defects, and there are still differences in the structure and function of the induced regeneration esophagus tissue and its own esophagus tissue. big gap

In 2000, Yamamoto et al. applied tissue engineering technology to study human esophagus. This is the application of the concept of "tissue engineering" in which autologous tissue cells are used to cultivate tissue grafts with physiological functions in vitro. The effect of tissue-engineered esophagus in specific clinical applications has not yet It can be seen

In 2005, Japan's Watanabe M et al. used nickel-titanium memory alloy rings to manufacture a peristaltic artificial esophagus, and used sheep for animal experiments, and the results are yet to be seen.

[0021] (4) The newborn esophagus will be narrowed

[0023] To sum up: in the prior art, there is still a lack of an anastomotic leak after implantation, which can induce and promote the growth and coverage of the new esophageal mucosa, can effectively resist the contraction force of the new esophageal scar tissue, and prevent the stenosis of the new esophagus. An artificial esophagus that can be taken out or removed in a non-invasive or minimally invasive way after the new esophageal mucosa is completely covered and the new esophageal scar tissue is stable

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