Bone repair porous compound scaffold based on 3D (three-dimensional)-Bioplotter printing technology and preparation method thereof

Abstract

The invention discloses a bone repair porous compound scaffold based on 3D (three-dimensional)-Bioplotter printing technology and a preparation method thereof. The scaffold is formed by compounding a matrix with a 3D macroporous structure and a drug carrying microsphere. The preparation method comprises the following steps: printing a scaffold matrix with a regular 3D macroporous structure through 3D-Bioplotter; preparing a drug carrying microsphere compounding hexagonal mesoporous silica (HMS), calcium silicate (CS) powder and PLGA through an emulsion solvent evaporation method; finally, fixing the compound microsphere into the matrix through low-temperature sintering so as to obtain the bone repair porous compound scaffold based on 3D-Bioplotter printing technology. According to the invention, the 3D printed porous scaffold and the PLGA / HMS / CS compound microsphere with drug sustained release and bone repair effects are combined, so that the scaffold has a macroporous structure, has good drug carrying and drug release properties and osteogenic differentiation capability and can be used for effectively promoting the repair and reconstruction of bone tissues.

Description

technical field [0001] The invention relates to the technical fields of biomedical engineering and biomedical materials, in particular to a porous composite scaffold for bone repair based on 3D-Bioplotter printing technology and a preparation method thereof. Background technique [0002] Bone is an important organ of the human body, responsible for functions such as support, movement, protection, hematopoiesis, mineral storage and metabolism. Clinically, large bone defects and osteoporosis caused by trauma, infection, tumor, and congenital dysplasia exceed the self-repair ability of bone, and bone repair treatment is required. Traditional bone defect treatment methods mainly include autologous bone transplantation and allogeneic bone transplantation. Due to the limited source of autologous bone transplantation and secondary surgery, it brings more pain to patients; allogeneic bone transplantation also has immune rejection and carries viruses. And the risk of bacteria, so th...

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Problems solved by technology

However, the above method can only prepare scaffolds with a pore size of less than 200 μm, and has the disadvantages of small porosity, difficult control of the geometry of the scaffold, and poor connectivity between pores.

For example, the pore size of the scaffold prepared by the phase separation method is relatively small; the gas foaming method cannot accurately control the porosity, the shape of the scaffold, and cannot make a larger pore size; the porogen content of the particle leaching method will seriously affect the mechanical strength of the scaffold. , and the residue of the porogen will lead to cytotoxicity; the mechanical properties of the scaffold prepared by electrospinning technology are low, etc.

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