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A new comprehensive pretreatment method for albendazole high-concentration sulfur-containing wastewater

A technology of albendazole and high concentration, which is applied in the field of comprehensive pretreatment of novel albendazole high-concentration sulfur-containing wastewater. Problems such as high cost of wastewater treatment

Active Publication Date: 2019-02-01
河南豫辰药业股份有限公司
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  • Summary
  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Albendazole is a high-efficiency broad-spectrum anthelmintic, which has a significant control effect on pinworms, nematodes, roundworms and other parasites in warm-blooded animals such as dogs and sheep. It can also be used for human brain-type and skin-muscle cysts. Insect disease, low toxicity to human body and animals, and small side effects. At present, o-nitroaniline is mainly synthesized with o-nitroaniline as a starting material at home and abroad, that is, o-nitroaniline undergoes thiocyanation reaction, alkylation reaction, reduction reaction, and ring reaction. Albendazole is prepared by combined reaction, but there is a large amount of sulfur-containing wastewater in the sodium sulfide reduction step, and the environmental protection pressure is relatively large. The albendazole reduction wastewater mainly contains sodium sulfide (Na 2 S), sodium thiosulfate (Na 2 S 2 o 3 ), sodium thiocyanate (NaSCN), sodium sulfite (Na 2 SO 3 ), sodium sulfate (Na 2 SO 4 ) and other sulfur-containing compounds, sodium bromide (NaBr) and a small amount of organic impurities, the pH of the wastewater is 12-13, and the cod is as high as 50000-140000mg / L. The production of albendazole produces sulfur-containing wastewater with a large amount of water, complex components, high sulfur content in sulfide, and serious pollution to the surrounding environment. , treatment is difficult. At present, domestic and foreign methods for treating sulfur-containing wastewater mainly include oxidation method, alkali absorption method, steam stripping method, precipitation method, Claus method, membrane separation method and biochemical method, etc., but these methods consume high energy consumption and chemical There is a large demand for medicines, a lot of investment equipment, and the need to reprocess end products such as sediment, so the cost is high, and it is easy to cause secondary pollution. Therefore, a high-concentration solution that is efficient, economical, fast, and has low requirements on equipment and processes is sought. The comprehensive pretreatment method of sulfur-containing wastewater and the effective recovery of by-products are urgent problems to be solved today
[0003] The purpose of the present invention is to solve the high cost of albendazole high-concentration sulfur-containing wastewater treatment and the problem of harsh treatment conditions, to provide a high-efficiency, fast, low equipment and process requirements, high removal efficiency, effective recovery of by-products, avoid Comprehensive pretreatment method for secondary pollution of high-concentration sulfur-containing wastewater

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A comprehensive pretreatment method for novel albendazole high-concentration sulfur-containing wastewater,

[0019] Specific steps are as follows:

[0020] First add 2000mL albendazole high-concentration sulfur-containing wastewater (COD 60000mg / L, PH 13, sodium sulfide determination 17000mg / L, sodium thiosulfate 8000mg / L, sodium thiocyanate 5000mg / L, sodium sulfite 3000mg / L, sulfuric acid Sodium 2000mg / L), add quantitative ferrous sulfate 33g, filter after reaction, obtain by-product ferrous sulfide 18.5g and filtrate 1, then add copper sulfate 39g to filtrate 1, filter after reaction, obtain by-product thiocyanic acid Subketone 7.5g and filtrate 2, filtrate 2 is cooled to 0 ~ 10 ℃, crystallization, obtain filtrate 3 and filter residue 3, filter residue 3 mainly contains sodium sulfate (Na 2 SO 4 ), after recrystallization, 38 g of by-product sodium sulfate was obtained, and the filtrate 3 mainly contained bromide ions, and bromine could be recovered. processing sys...

Embodiment 2

[0022] A comprehensive pretreatment method for novel albendazole high-concentration sulfur-containing wastewater,

[0023] Specific steps are as follows:

[0024] First add 2000mL albendazole high-concentration sulfur-containing wastewater (COD 60000mg / L, PH 13, sodium sulfide determination 17000mg / L, sodium thiosulfate 8000mg / L, sodium thiocyanate 5000mg / L, sodium sulfite 3000mg / L, sulfuric acid Sodium 2000mg / L), add quantitative ferrous sulfate 33g, filter after reaction, obtain by-product ferrous sulfide 18.5g and filtrate 1, then add copper sulfate 45g to filtrate 1, filter after reaction, obtain by-product thiocyanic acid Subketone 7.5g and filtrate 2, filtrate 2 is cooled to 0 ~ 10 ℃, crystallization, obtain filtrate 3 and filter residue 3, filter residue 3 mainly contains sodium sulfate (Na 2 SO 4 ), after recrystallization, 41 g of by-product sodium sulfate was obtained, and the filtrate 3 mainly contained bromide ions, and bromine could be recovered. processing sys...

Embodiment 3

[0026] A comprehensive pretreatment method for novel albendazole high-concentration sulfur-containing wastewater,

[0027] Specific steps are as follows:

[0028] First add 2000mL albendazole high-concentration sulfur-containing wastewater (COD 60000mg / L, PH 13, sodium sulfide determination 17000mg / L, sodium thiosulfate 8000mg / L, sodium thiocyanate 5000mg / L, sodium sulfite 3000mg / L, sulfuric acid Sodium 2000mg / L), add quantitative ferrous sulfate 39g, filter after reaction, obtain by-product ferrous sulfide 18.5g and filtrate 1, then add copper sulfate 39g to filtrate 1, filter after reaction, obtain by-product thiocyanic acid Subketone 7.5g and filtrate 2, filtrate 2 is cooled to 0 ~ 10 ℃, crystallization, obtain filtrate 3 and filter residue 3, filter residue 3 mainly contains sodium sulfate (Na 2 SO 4 ), after recrystallization, 43 g of by-product sodium sulfate was obtained, and the filtrate 3 mainly contained bromide ions, and bromine could be recovered. processing sys...

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Abstract

The invention relates to a novel comprehensive pretreatment method of high-concentration sulfur-containing wastewater in albendazole production and aims to solve the problem that high-concentration sulfur-containing wastewater in albendazole production is high in treatment cost and harsh in treatment condition. Albendazole high-concentration sulfur-containing wastewater mainly contains sulfur-containing compounds like sodium sulfide (Na2S), sodium thiosulfate (Na2S2O3), sodium thiocyanate (NaSCN), sodium sulfite (Na2SO3) and sodium sulfate (Na2SO4), sodium bromide (NaBr) and a small amount of organic impurities. The method includes: adding a fixed quantity of ferrous sulfate into the high-concentration sulfur-containing wastewater, and filtering after reaction to obtain byproducts ferrous sulfide and filtrate 1; adding copper sulfate into the filtrate 1, and filtering after reaction to obtain byproducts cuprous thiocyanate and filtrate 2; cooling the filtrate 2 to 0-10 DEG C, crystallizing to obtain filtrate 3 and filter residue 3 which mainly contains sodium sulfate (Na2SO4), and recrystallizing to obtain a byproduct anhydrous sodium sulfate, and entering wastewater after bromine is recycled, wherein the filtrate 3 mainly contains bromide ions and recyclable bromine. The pretreatment method is mild in reaction condition, low in equipment requirement, good in treatment effect, simple and convenient to operate, capable of recycling byproducts, low in treatment cost and convenient for industrial application.

Description

technical field [0001] The invention belongs to the technical field of sulfur-containing wastewater treatment, and in particular relates to a novel comprehensive pretreatment method for high-concentration albendazole-containing sulfur-containing wastewater. Background technique [0002] Albendazole is a high-efficiency broad-spectrum anthelmintic, which has a significant control effect on pinworms, nematodes, roundworms and other parasites in warm-blooded animals such as dogs and sheep. It can also be used for human brain-type and skin-muscle cysts. Insect disease, low toxicity to human body and animals, and small side effects. At present, o-nitroaniline is mainly synthesized with o-nitroaniline as a starting material at home and abroad, that is, o-nitroaniline undergoes thiocyanation reaction, alkylation reaction, reduction reaction, and ring reaction. Albendazole is prepared by combined reaction, but there is a large amount of sulfur-containing wastewater in the sodium sul...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C02F9/04C02F103/34C02F101/10C02F101/12
CPCC02F1/52C02F1/5236C02F9/00C02F2001/5218C02F2101/101C02F2101/12C02F2103/343
Inventor 段玉强石艳彩王心久杨晶晶王瑞菊付影敢
Owner 河南豫辰药业股份有限公司