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Composition for assisting interventional therapy of liver cancer and preparation method of composition

A composition and interventional technology, applied in the directions of drug combinations, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problems of difficulty in entering the hepatic artery, discomfort in the human body, and multiple reactions in the digestive tract, and enhance the digestive tract. Function, enhance body immunity, dilate blood vessels and arteries

Inactive Publication Date: 2016-09-28
赵伟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, interventional therapy has become one of the important treatment methods for liver cancer. Its advantages lie in its definite curative effect, scientific mechanism, simple operation, safety and reliability, clear diagnostic imaging, and low treatment cost. However, its disadvantages cannot be ignored, mainly in the following areas: Despite the super-selective access, there are still obvious side effects, and the gastrointestinal reaction is the most, which brings discomfort to the human body; the main blood supply of liver cancer depends on the hepatic artery, but there is portal vein blood supply around the tumor mass, so that cancer cells can secretly survive; the operation is difficult. , the catheter should be ultra-selective into the feeding artery for better efficacy, but sometimes it is difficult to enter the hepatic artery

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A composition for assisting interventional treatment of liver cancer, characterized in that the composition mainly includes the following components by weight: 3 parts of isorhamnetin, 2 parts of erionthyrin, 0.8 parts of kaempferol, 0.5 parts of paeonol 3 parts of arabinose, 0.6 parts of cantharidin, 0.3 parts of emodin, 0.2 parts of oleanolic acid, 0.05 parts of arginine, 0.06 parts of syringic acid, 0.1 parts of multivitamins, 0.03 parts of cyclosporin, succinic acid 0.05 parts, 1 part soybean glycopeptide, 0.8 parts magnesium stearate, 5 parts binder.

[0018] Wherein, the binder is pregelatinized starch, and the pregelatinized starch slurry can evenly wet the drug powder, because the jelly contains a large amount of water, and the water gradually diffuses into the powder after meeting the powder, and the distribution Uniform and uniform wetting, the starch slurry itself has a certain binding effect, the prepared pharmaceutical composition has good disintegration pe...

Embodiment 2

[0025] A composition for assisting interventional treatment of liver cancer, characterized in that the composition mainly includes the following components by weight: 5.5 parts of isorhamnetin, 3.5 parts of erionthyrin, 1.2 parts of kaempferol, 0.65 parts of paeonol 4 parts of arabinose, 0.75 parts of cantharidin, 0.4 parts of emodin, 0.3 parts of oleanolic acid, 0.1 parts of arginine, 0.08 parts of syringic acid, 0.15 parts of multivitamins, 0.055 parts of cyclosporin, succinic acid 0.07 parts, 2 parts soybean glycopeptide, 1 part magnesium stearate, 8.5 parts binder.

[0026] Wherein, the binder is pregelatinized starch, and the pregelatinized starch slurry can evenly wet the drug powder, because the jelly contains a large amount of water, and the water gradually diffuses into the powder after meeting the powder, and the distribution Uniform and uniform wetting, the starch slurry itself has a certain binding effect, the prepared pharmaceutical composition has good disintegrati...

Embodiment 3

[0033] A composition for assisting interventional treatment of liver cancer, characterized in that the composition mainly includes the following components by weight: 8 parts of isorhamnetin, 5 parts of erionthyrin, 1.6 parts of kaempferol, 0.8 parts of paeonol 5 parts of arabinose, 0.9 parts of cantharidin, 0.5 parts of emodin, 0.4 parts of oleanolic acid, 0.15 parts of arginine, 0.1 part of syringic acid, 0.2 parts of multivitamins, 0.08 parts of cyclosporin, succinic acid 0.09 parts, 3 parts of soybean glycopeptide, 1.2 parts of magnesium stearate, 12 parts of binder.

[0034] Wherein, the binder is pregelatinized starch, and the pregelatinized starch slurry can evenly wet the drug powder, because the jelly contains a large amount of water, and the water gradually diffuses into the powder after meeting the powder, and the distribution Uniform and uniform wetting, the starch slurry itself has a certain binding effect, the prepared pharmaceutical composition has good disinteg...

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PUM

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Abstract

The invention relates to a composition for assisting the interventional therapy of liver cancer and a preparation method of the composition. The composition is mainly prepared from the following components in parts by weight: 3-8 parts of isorhamnetin, 2-5 parts of eriodictyol, 0.8-1.6 parts of kaempferol, 0.5-0.8 part of paeonol, 3-5 parts of arabinose, 0.6-0.9 part of cantharidin, 0.3-0.5 part of rheum emodin, 0.2-0.4 part of oleanolic acid, 0.05-0.15 part of arginine, 0.06-0.1 part of syringic acid, 0.1-0.2 part of decavitamin, 0.03-0.08 part of cyclosporine, 0.05-0.09 part of butanedioic acid, 1-3 parts of soybean glycopeptide, 0.8-1.2 parts of magnesium stearate, and 5-12 parts of an adhesive. According to the composition, the medicinal materials are mixed for use, thus the effects of resisting cancer and diminishing inflammation, dilating blood vessels and arteries, and inhibiting the digestive tract injuries can be achieved during the interventional therapy of liver cancer; by adding various auxiliary materials, the composition can be prepared into tablets or capsules by adopting a conventional process; a use method is simple; and through clinical verifications, the composition has a very good auxiliary effect for the interventional therapy of liver cancer.

Description

technical field [0001] The invention relates to the technical field of medication for liver cancer interventional therapy, in particular to a composition for assisting liver cancer interventional therapy and a preparation method thereof. Background technique [0002] Interventional treatment of liver cancer is to make tiny channels with a diameter of a few millimeters on the blood vessels and skin without exposing the lesion by surgery, or through the original pipeline of the human body, in the imaging equipment (angiography machine, fluoroscopy machine, CT, MR). Under the guidance of , B-ultrasound) to treat the local lesion with the least trauma, it mainly refers to a kind of regional local chemotherapy that injects anticancer drugs or embolic agents into the hepatic artery through femoral artery catheterization. It is a non-open surgery It is the first choice method for the treatment of liver cancer, and its curative effect has been affirmed in clinical application. [0...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/14A61K38/13A61P35/00A61K9/48A61K9/20A61K31/352A61K31/12A61K31/7004A61K31/198A61K31/192A61K31/194A61K38/02A61K31/365A61K31/122A61K31/56
CPCA61K31/352A61K9/146A61K9/2054A61K31/12A61K31/122A61K31/192A61K31/194A61K31/198A61K31/365A61K31/56A61K31/7004A61K38/02A61K38/13A61K38/14A61K2300/00
Inventor 赵伟陆东霞杨洪青
Owner 赵伟
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