Preparation method of antibacterial hydrophobic ZnO nanorod

A nanorod, hydrophobic technology, applied in the direction of nanotechnology, nanotechnology, nanotechnology for materials and surface science, etc., can solve the problem of increasing patient hospitalization time and medical expenses, threatening the life safety of patients, and failure of implant surgery and other problems, to achieve the effect of preventing scaling and bacterial biofilm formation, the preparation method is simple and easy, and the implementation is less difficult

Active Publication Date: 2017-05-31
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, implant-associated infections often occur during or after surgery, leading to surgical implant failure, which is mainly caused by bacterial adhesion and biofilm formation
Once biofilms are formed on the implant surface, chronic infection will ensue, and traditional medical methods based on antibiotics are generally not very effective, because bacteria have certain resistance to antibiotics and chemical disinfection agents, which will eventually leading to implant removal
Removing the implant will increase the patient's hospitalization time and medical expenses, bring great pain to the patient in the process, and even threaten the patient's life safety

Method used

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  • Preparation method of antibacterial hydrophobic ZnO nanorod
  • Preparation method of antibacterial hydrophobic ZnO nanorod
  • Preparation method of antibacterial hydrophobic ZnO nanorod

Examples

Experimental program
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Effect test

Embodiment 1

[0050] (1) Mechanical polishing of titanium sheet (diameter 6mm, thickness 2mm): Polish the titanium sheet with 240, 600, 1200 and 2400 mesh emery on the polishing machine in turn, until the surface is smooth, then place the polished titanium sheet in acetone, no Ultrasonic cleaning for 15 minutes each in water ethanol and deionized water, and natural drying at room temperature for use;

[0051](2) Using the obtained polished titanium sheet as a substrate, a uniform ZnO seed layer is plated by a sol-gel method; the specific method is to prepare an ethanol solution of 0.75mol / L zinc acetate dihydrate and 0.75mol / L ethanolamine, Then continue stirring for 4 hours to obtain a colorless transparent colloid and store it at room temperature for 24 hours. After the sol is fully aged, the precursor solution is obtained. Use a spin coater to coat 30 μL of the precursor solution on the titanium sheet. 15 seconds, 5000 rpm for 30 seconds in the later stage, then blow dry with nitrogen ga...

Embodiment 2

[0054] (1) Mechanical polishing of titanium sheet (diameter 6mm, thickness 2mm): use 240, 600, 1200 and 2400 mesh emery on a polishing machine to polish the titanium sheet to a smooth surface, and then place the polished titanium sheet in acetone and anhydrous ethanol. Ultrasonic cleaning with deionized water for 15 minutes each, natural drying at room temperature, for use;

[0055] (2) Using the obtained polished titanium sheet as a substrate, a uniform ZnO seed layer is plated by atomic layer deposition, specifically: preparing a zinc oxide solution with diethyl zinc (DEZ) and water as a zinc source and an oxygen source As the precursor, the substrate is then deposited. Under the conditions of the deposition temperature of 100 °C, the deposition pressure of 40 Pa, and the deposition flow of 20 , high-purity nitrogen cleaning for 20s as a cycle for deposition (H 2 O / N 2 / DEZ / N 2 =0.1:20:0.1:20s), the number of cycles is 300, and a ZnO seed layer is obtained on the substrat...

Embodiment 3

[0058] (1) Mechanical polishing of titanium sheet (diameter 6mm, thickness 2mm): use 240, 600, 1200 and 2400 mesh emery on a polishing machine to polish the titanium sheet to a smooth surface, and then place the polished titanium sheet in acetone and anhydrous ethanol. Ultrasonic cleaning with deionized water for 15 minutes each, natural drying at room temperature, for use;

[0059] (2) Using the obtained polished titanium sheet as a substrate, a uniform ZnO seed layer is plated by a high vacuum magnetron sputtering method; specifically, by using radio frequency magnetron sputtering, the pressure is first reduced to below 6.0×10-4Pa , and then pass high-purity argon as the working gas until the pressure is 3.0Pa, the sputtering temperature is 25°C, the sputtering power is 120W, and the sputtering time is 120s;

[0060] (3) First prepare 0.025mol / L zinc nitrate hexahydrate (Zn(NO) 3 )2) 6H 2 O) and 0.025mol / L hexamethylenetetramine (C6H 12 N 4 ) of the aqueous solution 60ml...

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Abstract

The invention discloses a preparation method of an antibacterial hydrophobic ZnO nanorod. The preparation method comprises the following steps: (1) mechanical polishing of titanium pieces: the titanium pieces are polished in sequence to obtain smooth surfaces; and the polished titanium pieces are positioned in acetone, anhydrous ethanol and de-ionized water in sequence for respective ultrasonic cleaning by 15 minutes, and are naturally dried at room temperature for future use; (2) preparation of a ZnO seed layer: the polished titanium pieces obtained in the step (1) are used as a substrate to plate the uniform ZnO seed layer; and (3) preparation of a ZnO nanorod: the substrate coated with the ZnO seed layer in the step (2) is reversely suspended in water solution of zinc nitrate hexahydrate and hexamethylenetetramine for hydrothermal reaction and natural cooling; and after the substrate is taken out for cleaning by the de-ionized water, the substrate is dried to form the ZnO nanorod. The ZnO nanorod has the advantages of: better antibacterial efects, no need of high-temperature heating, no harmful gas, economy, environmental protection, broad spectrum, high efficiency, long bacteria resistance and a certain biological compatibility.

Description

technical field [0001] The invention relates to the technical field of titanium-based biological materials, in particular to a preparation method of antibacterial and hydrophobic ZnO nanorods. Background technique [0002] Titanium-based biomaterials have good biocompatibility, mechanical properties and excellent corrosion resistance, and have been widely used in orthopedic and dental implant materials. However, implant-related infections often occur during or after surgery, leading to implant failure, mainly due to bacterial adhesion and biofilm formation. Once a biofilm has formed on the implant surface, chronic infection can ensue, and traditional medical methods based on antibiotics generally do not work well because bacteria are resistant to antibiotics and chemical disinfection agents, which will eventually lead to removal of the implant. Removing the implant will increase the patient's hospital stay and medical expenses, cause great pain to the patient in the proces...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C18/12C23C18/04B82Y30/00A61L31/08A61L31/16A61L31/14
Inventor 吴水林李浚刘想梅向一鸣毛丛杨谭磊许子强
Owner HUBEI UNIV
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