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Cefixime dispersible tablets and preparation method thereof

A technology of cefixime and dispersible tablets, which is applied in the field of medicine, can solve the problems of poor solubility of cefixime, slow dissolution of ordinary tablets, unqualified substance inspection, etc., and achieve a product that promotes dissolution and absorption, has a pleasant taste, and is convenient to take Effect

Inactive Publication Date: 2018-03-23
HUAYI PHARMA ANHUI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The solubility of cefixime in water is poor, and the dissolution of ordinary tablets is slow and the onset of action is slow
Because the β-lactam ring on the structure of cefixime is easy to hydrolyze and open the ring to produce degradation products under moisture absorption and heat, and gradually loses its effectiveness. reaction

Method used

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  • Cefixime dispersible tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A cefixime dispersible tablet is made from the following raw materials in weight ratio: 50 parts of cefixime, 0.01 part of polyoxyethylene (20) sorbitan monooleate (Tween 80), 3 parts of loquat dew, 3 parts of disodium glycyrrhizinate, 2 parts of aspartame alitame, 3 parts of xanthan gum, 5 parts of citric acid, 4 parts of pentaerythritol, 2 parts of folded carboxymethyl starch sodium.

[0023] Wherein, the preparation method of xanthan gum is as follows: take 100 parts of corn starch with a moisture content lower than 8%, add 50wt% sterile water to make starch slurry; slowly stir the starch slurry, heat it to 37-42°C, and keep it warm. ; Add 10 to the starch slurry 5 -10 6 cfu / mL Xanthomonas 10mL, aerobically fermented for 36-72h, the fermented product is a high molecular weight, anionic polysaccharide polymer; the product obtained by vacuum drying at low temperature until the water content is less than 10% is the desired xanthan gum .

[0024] Among them, the prepa...

Embodiment 2

[0032] A kind of cefixime dispersible tablet, is made by the raw material of following weight ratio: 60 parts of cefixime, 0.05 part of polyoxyethylene (20) sorbitan monooleate (Tween 80), 5 parts of loquat dew, 5 parts of disodium glycyrrhizinate, 4 parts of aspartame alitame, 5 parts of xanthan gum, 8 parts of citric acid, 6 parts of pentaerythritol, 6 parts of folded carboxymethyl starch sodium.

[0033] Wherein, the preparation method of xanthan gum is as follows: take 100 parts of corn starch with a moisture content lower than 8%, add 50wt% sterile water to make starch slurry; slowly stir the starch slurry, heat it to 37-42°C, and keep it warm. ; Add 10 to the starch slurry 5 -10 6 cfu / mL Xanthomonas 10mL, aerobically fermented for 36-72h, the fermented product is a high molecular weight, anionic polysaccharide polymer; the product obtained by vacuum drying at low temperature until the water content is less than 10% is the desired xanthan gum .

[0034] Among them, the...

Embodiment 3

[0042] A cefixime dispersible tablet, made of the following raw materials in weight ratio: 55 parts of cefixime, 0.04 part of polyoxyethylene (20) sorbitan monooleate (Tween 80), 4 parts of loquat dew, 4 parts of disodium glycyrrhizinate, 3 parts of aspartame alitame, 4 parts of xanthan gum, 6 parts of citric acid, 6 parts of pentaerythritol, 6 parts of folded carboxymethyl starch sodium.

[0043] Wherein, the preparation method of xanthan gum is as follows: take 100 parts of soybean starch with a moisture content lower than 8%, add 50wt% sterile water to make starch slurry; slowly stir the starch slurry, heat it to 37-42°C, and keep it warm ; Add 10 to the starch slurry 5 -10 6 cfu / mL Xanthomonas 10mL, aerobically fermented for 36-72h, the fermented product is a high molecular weight, anionic polysaccharide polymer; the product obtained by vacuum drying at low temperature until the water content is less than 10% is the desired xanthan gum .

[0044] Among them, the prepara...

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Abstract

The invention provides a cefixime dispersible tablet, which relates to the technical field of medicine. The raw materials include: cefixime, polyoxyethylene (20) sorbitan monooleate (Tween 80), loquat dew, disodium glycyrrhizinate, Aspartame alitame, xanthan gum, citric acid, pentaerythritol, folded carboxymethyl starch sodium; including the following steps: mixing cefixime, disodium glycyrrhizinate, aspartame Methyl ester alitame and folded carboxymethyl starch sodium were subjected to ultrafine treatment until the granules were 200-250 mesh, sieved, mixed evenly to obtain a mixture; the remaining components were added to deionized water for ultrasonic treatment, and microwaved to obtain a solution; The mixture is added into the solution, microwaved, added to a high-efficiency wet granulator, and granulated; dried and compressed into tablets. The surface area of ​​the tablet of the invention increases after being dispersed, which can promote the dissolution and absorption of the medicine in the body, and can reduce the burden of the medicine on the gastrointestinal tract. It is convenient to take and take after dispersing with water.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a cefixime dispersible tablet and a preparation method thereof. Background technique [0002] Cefixime, chemical name: (6R,7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-(carboxymethoxyimino)acetamido]-8-oxo Dai-3-vinyl-5-thia-1-azabicyclo[4.2.0]-oct-2-ene-2-carboxylic acid trihydrate, cefixime is white to light yellow crystalline powder, odorless , with a slight specific odor, soluble in methanol, dimethyl sulfoxide, slightly soluble in acetone, insoluble in ethanol, almost insoluble in water, ethyl acetate, ether, hexane. [0003] Cefixime is an oral broad-spectrum cephalosporin, especially against Streptococcus in Gram-positive bacteria, Pneumococcus in Gram-negative bacteria, Neisseria gonorrhoeae in Gram-negative bacteria, Brabhanococcus catarrhalis, Escherichia coli, Klebsiella , Serratia spp., Proteus spp. and influenza bacilli have stronger antibacterial effects than other oral ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/546A61K47/46A61K47/28A61P31/04A61K36/73A61K31/704
CPCA61K31/546A61K9/2018A61K9/2068A61K31/704A61K36/73A61K2300/00
Inventor 操铖高煜
Owner HUAYI PHARMA ANHUI CO LTD
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