Levofloxacin hydrochloride capsule and preparation method thereof

A technology of levofloxacin hydrochloride and capsules is applied in the directions of capsule delivery, pharmaceutical formulations, and inactive medical preparations, which can solve the problems of improper selection of disintegrants, unsatisfactory drug dissolution rate, etc. cost, avoid the effect of excessive concentration

Inactive Publication Date: 2018-09-25
江苏黄河药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Levofloxacin hydrochloride has a wide range of uses. In the case of unbearable pain, the sooner the effect of the drug, the better. This requires that the substances in levofloxacin hydrochloride capsules can be dissolved quickly, so that the drug can take effect. And improper selection of lubricants, so that the dissolution rate of the drug is not very ideal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A levofloxacin hydrochloride capsule, comprising a capsule and levofloxacin hydrochloride granules filled in the capsule, the levofloxacin hydrochloride granules are made of the following parts by weight: 15 parts by weight of levofloxacin hydrochloride, 8 parts by weight of ethanol, 2 parts by weight of sodium palmitate, 30 parts by weight of starch, 20 parts by weight of microcrystalline cellulose, 30 parts by weight of croscarmellose sodium, 2 parts by weight of sodium lauryl sulfate, 3 parts by weight of propyl p-hydroxybenzoate, and 5 parts by weight of beeswax;

[0024] The capsule is made of the following materials in parts by weight: 35 parts by weight of acrylic resin, 30 parts by weight of liquid paraffin, 5 parts by weight of chitosan, 3.8 parts by weight of 1,3 butanediol and 1.2 parts by weight of citric acid.

[0025] The preparation method of described levofloxacin hydrochloride capsules, the steps are as follows:

[0026] (1) Mix acrylic resin, chitosan ...

Embodiment 2

[0031] A levofloxacin hydrochloride capsule, comprising a capsule and levofloxacin hydrochloride granules filled in the capsule, wherein the levofloxacin hydrochloride granules are made of the following parts by weight: 10 parts by weight of levofloxacin hydrochloride, 5 parts by weight of ethanol, and 3 parts by weight of sodium linolenate , 20 parts by weight of starch, 15 parts by weight of low-substituted hydroxypropyl cellulose, 15 parts by weight of crospovidone, 2 parts by weight of sodium stearate, 3 parts by weight of sodium lactate, and 5 parts by weight of lanolin;

[0032] The capsule is made of the following materials in parts by weight: 45 parts by weight of acrylic resin, 25 parts by weight of liquid paraffin, 8 parts by weight of chitosan, 5 parts by weight of 1,3 butanediol and 2 parts by weight of acetic acid.

[0033] The preparation method of described levofloxacin hydrochloride capsules, the steps are as follows:

[0034] (1) Mix acrylic resin, chitosan an...

Embodiment 3

[0039] A levofloxacin hydrochloride capsule, comprising a capsule and levofloxacin hydrochloride granules filled in the capsule, wherein the levofloxacin hydrochloride granules are made of the following parts by weight: 15 parts by weight of levofloxacin hydrochloride, 10 parts by weight of isopropanol, 1 part by weight of sodium linolenate Parts by weight, 20 parts by weight of starch, 10 parts by weight of lactose, 10 parts by weight of dextrin, 15 parts by weight of low-substituted hydroxypropyl cellulose, 15 parts by weight of crospovidone, 2 parts by weight of sodium stearate, 3 parts by weight of sodium lactate , 5 parts by weight of lanolin;

[0040] The capsule is made of the following materials in parts by weight: 40 parts by weight of acrylic resin, 25 parts by weight of liquid paraffin, 8 parts by weight of chitosan, 4 parts by weight of 1,3 butanediol and 2 parts by weight of tartaric acid.

[0041] The preparation method of described levofloxacin hydrochloride cap...

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Abstract

The invention relates to the technical field of medicine preparation, in particular to a levofloxacin hydrochloride capsule and a preparation method thereof. The levofloxacin hydrochloride capsule comprises a capsule and levofloxacin hydrochloride particles filled in the capsule, wherein the levofloxacin hydrochloride particles are prepared from the following substances in parts by weight: 1 to 30weight parts of levofloxacin hydrochloride, 3 to 12 weight parts of monohydric alcohol, 0.5 to 5 weight parts of fatty acid alkali metal salts and 50 to 100 weight parts of auxiliary materials. The auxiliary materials are extracts of camphor or herba menthae. The levofloxacin hydrochloride capsule provided by the invention has the advantages that through the mutual action between the auxiliary materials, the fast disintegration can be achieved, so that the medicine can be fast dissolved out; the medicine further achieves the effect; the medicine effect is improved; in addition, the local irritation of the medicine is small; the excessive local concentration of the medicine can be avoided; the medicine irritation is reduced; the characteristic of simple production process is realized; thecost is reduced; the method is suitable for large-scale industrial production.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a levofloxacin hydrochloride capsule and a preparation method thereof. Background technique [0002] Levofloxacin hydrochloride is the levorotatory form of ofloxacin, chemical name: (S)-(-)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piper Oxazine)-7-oxo-7H-pyridine-[1,2,3-de]-[1,4]benzoxazine-6-carboxylate hydrochloride hydrate. Its antibacterial activity is about twice that of ofloxacin, and its main mechanism of action is to inhibit the activity of bacterial DNA gyrase (bacterial topoisomerase II) and hinder bacterial DNA replication. It has the characteristics of broad antibacterial spectrum and strong antibacterial effect. For most Enterobacteriaceae, such as Escherichia coli, Klebsiella, Serratia, Proteus, Shigella, Salmonella, Citrobacter, Acinetobacter and Pseudomonas aeruginosa Gram-negative bacteria such as Monas, Haemophilus influenzae, and Neisseria g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/12A61K31/5383A61P31/04
CPCA61K9/1617A61K31/5383A61P31/04
Inventor 闫海粟唐登高陶元明裴雪梅李苗苗
Owner 江苏黄河药业股份有限公司
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