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Antibiotic-free feed additive for regulating intestinal stress reaction and preparation method of antibiotic-free feed additive

A technology of stress response and intestinal tract, which is applied in the forming or processing of animal feed, animal feed, application, etc., can solve the problems of weak effect, high cost of use, and large amount of use, so as to relieve intestinal stress response Effect

Inactive Publication Date: 2019-07-09
山东祥维斯生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although tannic acid has a certain astringent effect, it is used in a large amount. When tannic acid is used alone, more than 1 kg of hydrolyzed tannic acid is needed per ton of feed, and the cost of use is higher than that of current zinc oxide, but the effect is weak. ZnO

Method used

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  • Antibiotic-free feed additive for regulating intestinal stress reaction and preparation method of antibiotic-free feed additive

Examples

Experimental program
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Effect test

preparation example 1

[0079] Preparation of Gallic Tannin-Phospholipid / Betaine Complex

[0080] (1) Weigh an appropriate amount of purified gallic tannin 1kg, place it in a 20L solvent composed of equal volume ratio mixed absolute ethanol and sodium dihydrogen phosphate buffer (pH 6.8), stir and dissolve at room temperature, and prepare gallic tannin- Phosphate organic buffer solution.

[0081] (2) Weigh 480g of soybean lecithin and betaine according to the mass ratio of 2:1 and mix them, then add them to 2.5L of absolute ethanol, heat to 35°C, stir and dissolve fully, then pour the above Galla tannin-phosphate organic buffer solution, stir well.

[0082] (3) In a reaction kettle with condensing reflux, heat the above-mentioned reaction raw materials to a temperature of 60° C., magnetically stir the reaction for 1 h, then cool down to 5° C., let it stand for precipitation, filter the precipitated precipitate, and dry it to obtain the following: tannin-betaine complex-based complex component 1; ne...

preparation example 2

[0086] Preparation of enteric-coated granules containing tannin complex

[0087] (1) Take 1000 g of the above-prepared Galla tannin-phospholipid / betaine complex granule, 300 g of tributyrin, and 50 g of nano-zinc oxide, and mix them uniformly to obtain mixture 1; additional auxiliary materials: 200 g of cornstarch, mannose 150g of polysaccharide, 120g of microcrystalline cellulose, 60g of dextrin, 50g of calcium stearate, 20g of sodium carboxymethyl cellulose, 5g of polyvinylpolypyrrolidone, mix the above-mentioned auxiliary materials with mixture 1 in the mixer, and Add 120g of monoglyceride laurate at 65°C, stir at a speed of 80r / min for 15min, then add purified water and stir to form a wet granule soft material, and put the wet soft material into the swing granulator with a pore size of 60-80 mesh Squeeze out the material, put the material into a spheronizer for 15 minutes, and dry it in an oven for 2 hours to obtain core material particles.

[0088] (2) Preparation of ent...

preparation example 3

[0092] Preparation of betaine-sodium n-butyrate granules treated with anti-hygroscopic coating

[0093] (1) Mix 30 g of feed grade betaine hydrochloride, 100 g of whey protein powder, 5 g of sodium n-butyrate and 15 g of amino acids including equal weight methionine and lysine; add 180 g of corn starch, 40 g of beta -Cyclodextrin, and 18g microcrystalline cellulose, stir evenly, use 1wt% hydroxymethylcellulose sodium solution instead of purified water to prepare soft materials, make uniform granules in the granulator, and control the air intake of the granulator The temperature is 50-55°C, the particle size is controlled to be about 60 mesh, and the obtained product is dried;

[0094] (2) to the cellulose acetate ethanol solution of phthalate of 2wt% to the spraying mass fraction of gained granule product to carry out coating treatment (solution consumption is 5wt% of granule product); 2%, so as to obtain about 0.4 kg of betaine-n-butyric acid sodium salt granules treated wit...

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Abstract

The invention relates to a composite particle preparation for regulating intestinal stress states of egg laying poultry and other animals. The composite particle preparation comprises film-coated enteric particles of a tannin lipidosome compound and film-coated glycine betaine-sodium butyrate salt particles; the enteric particles containing the tannin liposome compound are composed of a tannin-phospholipid glycine betaine compound, tributyrin, nano-zinc oxide and auxiliary materials. The composite particle preparation has the advantages that for the intestinal characteristics, effective components can be released sectionally, and the intestinal stress states are effectively relieved and repaired to balanced states.

Description

technical field [0001] The invention belongs to the technical field of feed conditioning additives, and in particular relates to a conditioner composition for relieving intestinal stress response of animals, a preparation method and application thereof. Background technique [0002] In the breeding industry, with the development of intensive and large-scale farming, the probability of stress reactions in farmed animals is increasing, the most typical of which is intestinal stress reactions, which can easily cause damage to intestinal mucosal cells, ranging from Cause diarrhea and dehydration, and in severe cases lead to decreased immunity, various diseases and even livestock death. [0003] Stress response refers to the physiological response of the animal body to non-specific defense responses to external factors such as high temperature, long-distance transportation, and feed discomfort, among which gastrointestinal tract reactions are more common. Generally speaking, for...

Claims

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Application Information

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IPC IPC(8): A23K50/75A23K40/30A23K20/105A23K20/158A23K20/10A23K20/163A23K20/147A23K20/142A23K50/80A23K50/30A23K50/60A23K20/20
CPCA23K20/10A23K20/105A23K20/142A23K20/147A23K20/158A23K20/163A23K20/30A23K40/30A23K50/30A23K50/60A23K50/75A23K50/80Y02A40/818
Inventor 马琳马兴群韩强毛秀立
Owner 山东祥维斯生物科技股份有限公司
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