A kind of microencapsulated animal drug and preparation method thereof

Abstract

The invention relates to the technical field of veterinary drugs, in particular to a microencapsulated animal drug and a preparation method thereof. The microencapsulated animal medicine comprises a raw material medicine, a wall material and an external filler. The wall material is prepared from the following preparation raw materials in parts by weight: 30-40 parts of gelatin and 30-50 parts of saccharides; and the external filler comprises the following preparation raw materials in parts by weight: 30-40 parts of corn starch or rice bran and 3-8 parts of microcrystalline cellulose. Accordingto the invention, external auxiliary materials are applied to effectively solve the problem of wall sticking in a spray drying process; the microencapsulated animal medicine has the characteristics of round particles, good capsule material coating effect and good free-flowing property, and effective medicine components are isolated from the outside, so that the purposes of masking taste, preventing moisture, improving medicine stability and improving medicine utilization rate are achieved.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a microencapsulated animal medicine and a preparation method thereof. Background technique [0002] Microcapsule technology is a technology that uses natural or synthetic polymer film-forming materials (wall materials) to embed liquid or solid drugs (capsule materials) to form microcapsule particles with a diameter of 100-500 μm. The process of preparing microcapsule particles Referred to as microencapsulation. Drug microencapsulation has the advantages of masking the bitter or peculiar smell of drugs, improving drug fluidity and hygroscopicity, improving drug stability, controlling drug release, and reducing gastrointestinal irritation. Therefore, the preparation method of microencapsulated drugs has become very popular at present. , are widely used in various industries. [0003] At present, there are three main methods for preparing microencapsulated drugs: one i...

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Problems solved by technology

[0003] At present, there are three main methods for preparing microencapsulated drugs: one is the boiling granulation method, in which the powdery material is put into a closed container, and due to the action of hot air flow, the powdery material is suspended in a fluidized state in the container, and sprayed into the container at the same time. The binder is atomized to make the powder agglomerate into small particles, but the production equipment of this method is mostly batch production, which cannot meet the requirements of the assembly line, and the product particles are irregular, which is not suitable for easily oxidized and heat-sensitive materials. Not applicable

The second is the fluidized bed coating method, which is the main method for forming powdery and crystalline drugs into microcapsules based on physical and mechanical principles, but the coated drugs have a large specific surface area, and particles often occur during the preparation process. The phenomenon of adhesion and electrostatic adsorption, and the coating process takes a long time, consumes a lot of energy, high production cost and low production efficiency

For example, the document "Research on the Preparation and Properties of Tiamulin Fumarate Taste-masking Microcapsules" (first author: Han Jing) discloses that gelatin, β-cyclodextrin and castor oil are used as auxiliary materials and prepared by spray-drying method. Tiamulin fumarate microcapsules can effectively cover up the unpleasant smell of the API, and improve the hygroscopicity and fluidity of the microcapsules, but it also points out that the process is prone to sticking to the wall during the spray drying process

Another example is the patent document CN105287433A which discloses a preparation method of microencapsulated animal medicines. The method uses gelatin, sugars, β-cyclodextrin, and castor oil as auxiliary materials, which can also achieve taste masking, moisture resistance, and improve the bioavailability of drugs. The purpose of high efficiency, but its microemulsion contains more sugars, and the material has relatively strong cohesiveness, so the problem of sticking to the wall is more likely to occur during the spray drying process

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