Near-infrared fluorescent probe responding to peroxynitroso anions, and preparation method and application thereof

A technology of peroxynitroso and fluorescent probes, applied in the field of biochemistry, can solve the problems of short half-life and unreported fluorescent probes, and achieve the effects of small light damage, saving reaction costs, and mild reaction conditions
CN110669501AActive Publication Date: 2020-01-10NANJING FORESTRY UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANJING FORESTRY UNIV
Publication Date
2020-01-10

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Abstract

The invention discloses a near-infrared fluorescent probe responding to peroxynitroso anions, and a preparation method and an application thereof. The structure of the near-infrared fluorescent probeis shown in the description. The preparation method has the advantages of easiness in obtaining of raw materials, mild and easily-controlled reaction conditions, and saving of the reaction cost, and the obtained near-infrared fluorescent probe responding to peroxynitroso anions has a high selectivity and can be applied to a Parkinson's disease model.
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Description

technical field

[0001] The invention relates to a near-infrared fluorescent probe responsive to peroxynitrite anions, a preparation method and application thereof, and belongs to the technical field of biochemistry. Background technique

[0002] Parkinson's disease (PD) is a common neurodegenerative disorder that seriously affects people's daily life. Loss of dopaminergic neurons in the substantia nigra of the brain is the main pathological feature of Parkinson's disease. However, the reason for the decrease in dopamine in the substantia nigra neurons has not yet been clarified. Accumulating evidence suggests that damage to dopaminergic neurons is associated with neurotoxicity from overproduced reactive oxygen / nitrogen species in neurons.

[0003] Peroxynitrite anion (ONOO - ), composed of nitric oxide (NO) and superoxide anion (O 2 - ) produced, as an important active oxygen species, has high oxidation and nitrification ability. Low concentration of ONOO - Plays an i...

Claims

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