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Molybdenum oxide nanosheet plugging hollow mesoporous silicon nano material, and preparation method and application thereof

A nano-composite material and mesoporous silicon technology, which can be used in wave energy or particle radiation treatment materials, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., which can solve the problem of low drug loading rate, drug loss, etc. problems, to achieve the effect of increasing treatment efficiency, high loading capacity, and improving curative effect

Active Publication Date: 2020-03-27
DONGHUA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The technical problem to be solved by the present invention is to provide a molybdenum oxide nanosheet plugging hollow mesoporous silicon nanomaterial and its preparation and application, so as to overcome the low drug loading rate of the molybdenum oxide sheet material itself and the easy circulation of drugs in the blood. The missing defects in the molybdenum oxide MoO modified by polyethylene glycol-modified distearoylphosphatidylethanolamine mPEG-DSPE in the present invention x Drug-loaded composite material system obtained by plugging drug-loaded hollow mesoporous silicon with nanosheets

Method used

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  • Molybdenum oxide nanosheet plugging hollow mesoporous silicon nano material, and preparation method and application thereof
  • Molybdenum oxide nanosheet plugging hollow mesoporous silicon nano material, and preparation method and application thereof
  • Molybdenum oxide nanosheet plugging hollow mesoporous silicon nano material, and preparation method and application thereof

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Effect test

Embodiment 1

[0052] (1) Disperse 3g of ammonium molybdate into 30mL of ultrapure water, then add 1mL of hydrochloric acid (concentration: 1mol / L), ultrasonicate for five minutes, disperse 2g of oleylamine into 10mL of cyclohexane, and dissolve the oleylamine dispersion Slowly added to the ammonium molybdate dispersion, stirred magnetically for half an hour, and reacted the product at 200°C for 15 hours. After the reaction, the product was collected and centrifuged, and then washed and collected with chloroform and ethanol to obtain MoOx.

[0053] (2) Disperse the molybdenum dioxide material prepared in step (1) into 50 mL of chloroform solution, and then ultrasonicate the solution for 150 min in an ice bath to process large nanosheets into small fragments and reduce the particle size. After sonication, 500 mg of mPEG-DSPE was added, stirred overnight at room temperature, and chloroform was evaporated by rotary evaporation to obtain a dark brown dry substance, which was washed with ultrapure...

Embodiment 2

[0063] HMONs-NH of the present invention 2 -DOX@MoO x -The method of carrying out the drug release experiment of the PEG drug-carrying system:

[0064] (1) Prepare DOX phosphate buffer solution and acetic acid buffer solution, detect the maximum absorbance value in an ultraviolet spectrophotometer, and fit the DOX standard curve under two pH environments (5.0,7.4);

[0065] (2) 5mg HMONs-NH 2 -DOX@MoO x -The PEG drug-loaded composite material was dissolved in 5 mL of buffer solution, placed in two dialysis bags, and then the dialysis bags were placed in buffer solutions of pH 5.0 and pH 7.4 for shaking, samples were taken at different time points, and fresh buffer was added, A pH-responsive drug release curve was obtained.

[0066] (3) 5mgHMONs-NH 2 -DOX@MoO x -The PEG drug-loaded composite material was dissolved in 5mL of different pH buffer solutions (5.0 and 7.4), placed in a dialysis bag, and then treated with 808nm, 1W / cm 2 The laser was irradiated for 5 minutes, a...

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Abstract

The invention relates to a molybdenum oxide nanosheet plugging hollow mesoporous silicon nano material, and a preparation method and application thereof. The molybdenum oxide nanosheet plugging hollowmesoporous silicon nano material is obtained by plugging hollow mesoporous silicon by polyethylene glycol modified distearoyl phosphatidyl ethanolamine mPEG-DSPE. The preparation method is simple tooperate, the experimental conditions are easy to control, and the method has a prospect of industrial implementation.

Description

technical field [0001] The invention belongs to the field of functional nanocomposite materials and their preparation and application, in particular to a hollow mesoporous silicon nanometer material blocked by molybdenum oxide nanosheets and its preparation and application. Background technique [0002] Malignant tumors seriously threaten human health and life. In recent years, the morbidity and mortality of tumors have been increasing. Cancer treatment has become a major challenge in the current medical research field. At present, the treatment methods for tumors are mainly surgical resection, radiotherapy, and chemical drug therapy, and some tumors also use gene and biological therapy as adjuvant therapy. As a means of systemic treatment, chemotherapy drugs can effectively fight against the invasion and metastasis of tumor cells, so chemotherapy plays a dominant role in the comprehensive treatment of tumors. However, traditional chemotherapeutic drugs still have certain l...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/02A61K47/04A61K47/24A61K47/10A61K31/704A61K41/00A61P35/00
CPCA61K9/5115A61K9/5146A61K9/5192A61K31/704A61K41/0042A61K41/0052A61P35/00A61K2300/00
Inventor 朱利民李昱吴建荣杨延波牛世伟张雪静谢晓田
Owner DONGHUA UNIV
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