The invention discloses oral
insulin liposome hydrogel and application thereof, and belongs to the technical field of
insulin pharmacy. The oral
insulin liposome hydrogel comprises an insulin-loaded
liposome and a hydrogel with a core-shell structure formed by modified
sodium alginate, the core is the insulin-loaded liposome, and the shell is a hydrogel framework formed by the modified
sodium alginate; the insulin-loaded liposome is formed by mixing an insulin compound,
phosphatidyl ethanolamine and
cholesterol in an
organic solvent, the particle size of the insulin-loaded liposome is 100-200 nm, and the PD I value of the insulin-loaded liposome is 0.1-0.4; the modified
sodium alginate is obtained by reacting sulfydryl-containing
amino acid with
sodium alginate. Comprising the oral insulin liposome hydrogel prepared by the invention can be orally administered to a patient, and compared with injection, the oral insulin liposome hydrogel has the advantages that the pain of the patient is small, repeated administration is not needed, and the
blood sugar control is stable; the hypoglycemic effect is good, the hypoglycemic duration is long, the effect is remarkable, and the
bioavailability of insulin is high.