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Glucosamine chondroitin calcium tablet and preparation method thereof

A technology of chondroitin and chondroitin sulfate sodium, which is applied in bone diseases, sugar-coated pills, pharmaceutical formulas, etc., can solve the problems of insufficient hardness of the composition, easy oxidation of the composition, and insufficient stability of performance, so as to achieve stable drug effect and high product quality. Guaranteed quality and scientific design

Inactive Publication Date: 2020-04-14
众生健康(广东)科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese patent CN106235311A discloses a composition that promotes the health of the bone repair system, and its composition includes skim milk powder, fructooligosaccharides, beef bone consumption, orange fruit powder, D-glucosamine hydrochloride, bone collagen, sulfuric acid Chondroitin, Epimedium extract, Rhizoma Drynaria extract, mushroom powder, magnesium stearate and other ingredients have significant preventive and therapeutic effects on osteoporosis patients and people with skeletal system disorders, but due to the presence of many raw materials in the preparation process Impurity components make the hardness of the prepared composition insufficient, and the composition is easily oxidized when exposed to the air, and the performance is not stable enough. Therefore, there is an urgent need for a glucosamine chondroitin calcium tablet with good hardness and high stability

Method used

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  • Glucosamine chondroitin calcium tablet and preparation method thereof
  • Glucosamine chondroitin calcium tablet and preparation method thereof
  • Glucosamine chondroitin calcium tablet and preparation method thereof

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Effect test

Embodiment 1～5

[0041] Embodiments 1 to 5, Glucosamine Chondroitin Calcium Tablets of the Present Invention and Preparation Method The formulations of the Glucosamine Chondroitin Calcium Tablets of Embodiments 1 to 5 of the present invention are shown in Table 1:

[0042] Table 1

[0043]

[0044]

Embodiment 1～4

[0045] Embodiment 1~4, the preparation method of glucosamine chondroitin calcium tablet

[0046] S1. Sieve: Weigh the glucosamine sodium sulfate, sodium chondroitin sulfate, calcium carbonate, collagen peptide, epimedium extract, microcrystalline cellulose, and sorbitan monostearate of Examples 1 to 4, respectively , sodium carboxymethyl starch, croscarmellose sodium and magnesium stearate are respectively passed through an 80-mesh sieve, and set aside;

[0047] S2. Mixing: the glucosamine sodium sulfate, sodium chondroitin sulfate, calcium carbonate, collagen peptide, epimedium extract, microcrystalline cellulose, sorbitan monostearate and sodium carboxymethyl starch obtained in step S1 Mix with each other for 30 minutes to get mixed powder;

[0048] S3. Granulation: add 15 mL of ethanol solution with a volume fraction of 95% to the mixed powder, pass through a 20-mesh sieve and granulate to obtain wet granules, and dry the wet granules at 55°C until the moisture content is <7...

Embodiment 5

[0050] Embodiment 5, the preparation method of glucosamine chondroitin calcium tablet

[0051] S1. Sieving: Take respectively the glucosamine sulfate sodium, chondroitin sulfate sodium, calcium carbonate, collagen peptide, Epimedium extract, microcrystalline cellulose, sorbitan monostearate, carboxylate Methyl starch sodium, croscarmellose sodium and magnesium stearate are respectively passed through 80 mesh sieves, and set aside;

[0052] S2. Mixing: the glucosamine sodium sulfate, sodium chondroitin sulfate, calcium carbonate, collagen peptide, epimedium extract, microcrystalline cellulose, sorbitan monostearate and sodium carboxymethyl starch obtained in step S1 Mix with each other for 30 minutes to get mixed powder;

[0053] S3. Granulation: add 15 mL of ethanol solution with a volume fraction of 95% to the mixed powder, pass through a 20-mesh sieve and granulate to obtain wet granules, and dry the wet granules at 55°C until the moisture content is <7%;

[0054] S4. Tabl...

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Abstract

Relating to the technical field of health food, the invention provides a glucosamine chondroitin calcium tablet and a preparation method thereof. The glucosamine chondroitin calcium tablet disclosed by the invention is composed of the following raw materials: 100-200 weight parts of glucosamine sodium sulfate, 100-200 weight parts of sodium chondroitin sulfate, 80-140 weight parts of calcium carbonate, 150-180 weight parts of collagen peptide, 140-180 weight parts of a herba epimedii extract and 200-350 weight parts of an auxiliary material. The cooperative use of sorbitan monostearate and microcrystalline cellulose improves the cohesion among particles, and enhances the hardness of the glucosamine chondroitin calcium tablet, so that the prepared glucosamine chondroitin calcium tablet doesnot easily absorb external moisture, is not easily damped and is not oxidized easily, therefore the improving effect of the calcium tablet on osteoarthritis is stable.

Description

technical field [0001] The invention relates to the field of health food, in particular to a glucosamine chondroitin calcium tablet and a preparation method thereof. Background technique [0002] Osteoarthritis (OA) is a chronic, degenerative disease in which cartilage wears out in the knee joint, and is the most common chronic progressive joint disease. Its pathological features are degeneration and destruction of articular cartilage, subchondral bone sclerosis, reactive hyperplasia of joint margins and subchondral bone, and osteophyte formation, resulting in joint deformity and loss of function. The characteristics of the patient include swelling of the knee joint, pain, difficulty in walking, and difficulty in going up and down stairs, which eventually leads to loss of walking function of the knee joint. With the intensification of population aging, osteoarthritis and a series of health problems caused by middle-aged and elderly people deserve special attention. There a...

Claims

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Application Information

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IPC IPC(8): A61K9/28A61K38/39A61K47/38A61P19/02A61P29/00A61K31/7008A61K31/737A61K33/10A61K36/296
CPCA61K9/2054A61K9/2806A61K31/7008A61K31/737A61K33/10A61K36/296A61K38/39A61P19/02A61P29/00A61K2300/00
Inventor 张凯王一飞于留荣高旭华
Owner 众生健康(广东)科技有限公司
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