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Controllable fluorine slow-release hydroxyapatite porous microsphere carrier material and preparation method thereof

A technology for slow-release hydroxyapatite and carrier materials, applied in chemical instruments and methods, prostheses, phosphorus compounds, etc., can solve problems such as complex regulation mechanisms, achieve low equipment requirements, simple and easy hydrothermal reaction, strong The effect of industrialization prospects

Pending Publication Date: 2021-03-23
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when multiple ions coexist, the regulation mechanism of the substitution ions on the crystal growth and self-assembly process is very complicated.

Method used

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  • Controllable fluorine slow-release hydroxyapatite porous microsphere carrier material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) Add 0.0455mol calcium nitrate, 0.0045mol strontium nitrate, 0.15mol urea and 0.002mol ammonium fluoride successively in a beaker with 100ml distilled water, stir and dissolve to obtain a mixed solution;

[0027] (2) Add 0.03mol diammonium hydrogen phosphate to the mixed solution, stir at room temperature, add dropwise 0.1mol / l dilute nitric acid to clarify the turbid solution, and control the pH value to 2.5;

[0028] (3) transfer the clarified solution into a stainless steel hydrothermal synthesis kettle lined with polytetrafluoroethylene, with a filling capacity of 70%, adjust the hydrothermal temperature to 120°C, and the hydrothermal time to be 60h; after the reaction, the obtained The milky white precipitate was washed with distilled water until the pH value was 7, and finally filtered with absolute ethanol; the obtained filter cake was dried in a drying oven at 100°C for 24 hours. The resulting product is ground in a grinding bowl, and then sieved with a 325-m...

Embodiment 2

[0031] (1) Add 0.0225mol calcium hydroxide, 0.0020mol strontium nitrate, 0.1mol urea and 0.0025mol ammonium fluoride successively in a beaker with 100ml distilled water, stir and dissolve to obtain a mixed solution;

[0032] (2) Add 0.015mol phosphoric acid to the mixed solution, stir at room temperature, add dropwise dilute nitric acid of 0.1mol / L to clarify the turbid solution, and the pH when clarified is 3;

[0033] (3) Transfer the clarified solution into a polytetrafluoroethylene-lined stainless steel hydrothermal synthesis kettle with a filling capacity of 80%, adjust the hydrothermal temperature to 150° C., and the hydrothermal time to 75 hours. After the reaction, the obtained milky white precipitate was washed with distilled water until the pH value was 7, and finally filtered with absolute ethanol. The obtained filter cake was dried in a drying oven at 120° C. for 24 h. The resulting product is ground in a grinding bowl, and then sieved with a 270-mesh sieve to fin...

Embodiment 3

[0036] (1) Add 0.095mol calcium acetate, 0.008mol strontium chloride, 0.15mol hexamethyltetramine and 0.015mol sodium fluoride successively in a beaker with 100ml distilled water, after mixing, stir and dissolve to obtain a mixed solution;

[0037] (2) Add 0.06mol disodium hydrogen phosphate to the mixed solution, stir at room temperature, add dropwise dilute nitric acid of 0.1mol / L to clarify the turbid solution, and the pH when clarified is about 2.4;

[0038] (3) Transfer the clarified solution into a stainless steel hydrothermal synthesis kettle lined with polytetrafluoroethylene, with a filling capacity of 60%, adjust the hydrothermal temperature to 140°C, and the hydrothermal time to be 72h. After the reaction, the obtained The milky white precipitate was washed with distilled water until the pH value was 7, and finally filtered with absolute ethanol. The obtained filter cake was dried in a drying oven at 90° C. for 48 h. The resulting product is ground in a grinding bo...

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Abstract

The invention discloses a controllable fluorine slow-release hydroxyapatite porous microsphere carrier material and a preparation method thereof. Fluorine ions loaded in an apatite structure are usedas a fluorine source, and the self-assembly of carrier porous microspheres is regulated and controlled through strontium ion substitution and reaction conditions under the condition of no template agent, so that a fluorine and strontium composite doped regular porous spherical apatite carrier material is synthesized in a hydrothermal environment. The dissolution and absorption of the apatite are regulated and controlled by controlling the composition and microstructure of the carrier, so that the slow release of fluorine ions in the apatite structure is regulated and controlled. The material has good biological properties, can maintain the effective fluorine release concentration for a long time, significantly promotes osteogenesis of cells, and treats osteoporosis. The preparation methoddisclosed by the invention is simple and feasible, has low requirements on equipment, is simple to operate, and can be used for obtaining the apatite porous microsphere carrier with the average pore diameter of about 100 to 500 nm, the particle size of 1 to 50 [mu]m and the fluorine release concentration and the long-term effect meeting the requirements of a fluorine therapy material.

Description

technical field [0001] The invention relates to the field of medical biological fluorine slow-release materials, in particular to a controllable fluorine slow-release hydroxyapatite porous microsphere carrier material and a preparation method thereof. Background technique [0002] Osteoporosis is a syndrome of abnormal bone metabolism characterized by decreased bone mass, microarchitectural disruption of bone tissue, increased bone fragility, and susceptibility to fracture. It is reported that 7% of adults in my country suffer from osteoporosis, and the incidence rate of osteoporosis in women older than 50 years is as high as 40.1%. At the same time, the loss of mobility, hospitalization, and nursing costs caused by fractures have also brought heavy economic burdens to society and families. Relevant survey results show that the per capita costs of hip fractures and spine fractures in my country are as high as 27,283 and 25,715 RMB, respectively. Fluoride is recognized as a...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/02A61L27/50A61L27/54A61L27/56C01B25/32
CPCA61L27/12A61L27/025A61L27/54A61L27/56A61L27/50C01B25/32A61L2300/106A61L2300/412A61L2430/02C01P2004/61C01P2006/16C01P2004/34C01P2004/03
Inventor 朱庆霞聂全义韩委委耿宏章
Owner TIANJIN POLYTECHNIC UNIV
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