Embolism microsphere capable of being secondarily expanded and preparation method of embolism microsphere

Abstract

The invention discloses an embolism microsphere capable of being secondarily expanded. The invention relates to a water-based adhesive which is prepared from vinyl pyrrolidone, acrylic acid, sodium acrylate, methacrylic acid, sodium methacrylate, acrylamide, 2-acrylamide-2-methyl propanesulfonic acid, 2-acrylamide-2-methyl propanesulfonic acid sodium salt, allylamine, allylamine hydrochloride, dimethyl diallyl ammonium chloride and water. The preparation method comprises the following steps: carrying out cross-linking polymerization on one or more monomers in methyl acryloyl ethyl sulphobetaine to obtain a microsphere, carrying out primary expansion on the microsphere in pure water at 20 DEG C for 1-2 hours until the diameter is 2-3 times that of the microsphere in a dry state, taking out the microsphere, putting the microsphere in a PBS (Phosphate Buffer Solution) with a pH value of 7.4 at 37 DEG C for 48-72 hours, and carrying out secondary expansion, so that the diameter of the microsphere expanded again is increased by 10-30% compared with that of the microsphere expanded for the first time, and the diameter of the microsphere expanded again is increased by 10-30% compared with that of the microsphere expanded for the first time. According to the present invention, the suppository can primarily swell in water or a drug solution, can swell again in the blood vessel environment at the body temperature after being conveyed to the embolism position in the blood vessel, has characteristics of slow swelling speed, limited swelling rate, safety and controllability, can fully fit the shape of the blood vessel, can strengthen the embolism effect, and can easily achieve permanent embolism;

Description

Technical field [0001] The present invention involves the field of biomedical and polymer materials, and specially involves a secondary swelling embolism microsphere and its preparation methods. Background technique [0002] In recent years, intervention in embolism has played an increasingly important role in clinical medicine. It has played an irreplaceable role in treating capillary, dynamic venous malformations, dynamic fistula, enrichment of vascular tumors, and uterine fibroids. Its applications have made some of the original dangerous surgery more secure. The ideal embolism must be obstructed to completely and permanent blood supply. Therefore, the embolism is required to successfully enter the pre -embolism blood vessels, but also fully fit the blood vessel shape and not fall off by the blood. [0003] At present, the embolism micro -ball products on the market are hydrogel micro -balls with polyethylene glycol (PVA) as the main materials. They have good elasticity and hi...

AI Technical Summary

Problems solved by technology

[0003] At present, the embolic microspheres on the market are all hydrogel microspheres with polyvinyl alcohol (PVA) as the main material, which have good elasticity and high recovery rate after compression. When the blood moves to the position where the diameter of the blood vessel is smaller than the diameter of the microsphere, it will be stuck and form an embolism. However, due to its inherent spheroid shape, the conformability is poor, and it cannot form a good fit with the shape of the blood vessel, especially in some complex shapes or relatively elastic. Good embolization effect cannot be obtained in poor blood vessels. If such microspheres with larger diameters are used for such blood vessels, the direct extrusion of the spheres may cause the risk of blood vessel damage and lead to more serious medical conditions. More likely The spheres cannot be transported to the exact position to form an effective embolism