The invention discloses an
embolism microsphere capable of being secondarily expanded. The invention relates to a water-based
adhesive which is prepared from vinyl pyrrolidone,
acrylic acid,
sodium acrylate,
methacrylic acid,
sodium methacrylate,
acrylamide, 2-
acrylamide-2-methyl propanesulfonic acid, 2-
acrylamide-2-methyl propanesulfonic acid
sodium salt,
allylamine,
allylamine hydrochloride, dimethyl diallyl
ammonium chloride and water. The preparation method comprises the following steps: carrying out cross-linking
polymerization on one or more monomers in methyl acryloyl ethyl sulphobetaine to obtain a
microsphere, carrying out primary expansion on the
microsphere in pure water at 20 DEG C for 1-2 hours until the
diameter is 2-3 times that of the microsphere in a dry state, taking out the microsphere, putting the microsphere in a PBS (
Phosphate Buffer Solution) with a pH value of 7.4 at 37 DEG C for 48-72 hours, and carrying out secondary expansion, so that the
diameter of the microsphere expanded again is increased by 10-30% compared with that of the microsphere expanded for the first time, and the
diameter of the microsphere expanded again is increased by 10-30% compared with that of the microsphere expanded for the first time. According to the present invention, the
suppository can primarily swell in water or a
drug solution, can swell again in the
blood vessel environment at the body temperature after being conveyed to the
embolism position in the
blood vessel, has characteristics of slow swelling speed, limited swelling rate, safety and
controllability, can fully fit the shape of the
blood vessel, can strengthen the
embolism effect, and can easily achieve permanent embolism;