Method for preparing alpha, beta unsaturated alcohol from compound of ketone or aldehyde containing carbonyl

Abstract

A process for preparing unsaturated alpha, beta-alcohol from the carbonyl contained ketone or aldehyde compound includes mixing strong-alkaline compound with organic solvent, filling acetylene gas, dropping carbonyl contained ketone or aldehyde compound, reaction while stirring, solid-liquid separation to remove solid alkali, adding acidic compound, releasing unsaturated alpha, beta-ethynol, water washing to obtain liquid product of unsaturated alpha, beta-ethynol, vacuum distilling to obtain unsaturated alpha, beta-ethynol, and hydrogenating to obtain unsaturated alpha, beta-enol.

Description

technical field [0001] The invention relates to a method for preparing α, β-unsaturated alcohols, in particular to a method for preparing α, β-unsaturated alkynols or α, β-unsaturated enols from carbonyl-containing ketones or aldehyde compounds. Background technique [0002] As long as the α, β-position contains unsaturated bond alcohol compounds can be called α, β-unsaturated alcohol compounds, but in general, α, β-unsaturated alcohol compounds mainly refer to α, β- Alcohol compounds containing unsaturated C=C bonds or C≡C bonds. Through the addition reaction of ketones or aldehydes containing carbonyl groups with compounds containing alkene groups such as vinyl or alkyne groups such as ethynyl, α, β-unsaturated alcohols containing allyl groups or containing propargyl groups can be generated. α,β-unsaturated alcohols. α, β-unsaturated alcohols are very important compounds, especially most of them are important spices or pharmaceutical int...

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Problems solved by technology

α, the partial hydrogenation reduction of β-unsaturated acetylenic alcohol product, except the Lindlar catalyst that can use Pd content 0.25%, can also use the catalyst that noble metals such as: nickel, cobalt, palladium, platinum, rhodium, iridium etc. make, also can use Na, LiAlH can be used 4 Wait for the reducing agent to reduce, but it is easy to reduce the product yield and product quality due to excessive reduction

The main disadvantage of the "ethynylation reduction method" is the need for low temperature and a large amount of liquid ammonia, strict operating requirements, a high-pressure closed reaction system, and a decompression evaporation and compression recovery treatment device, the possibility of air pollution caused by a large amount of ammonia overflow very big

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