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Strontium containing hydroxyapatite biologically active film and preparation method thereof

A strontium hydroxyapatite and biologically active technology, applied in the field of strontium-containing hydroxyapatite bioactive film layer and its preparation, can solve the problems of difficult control of film composition, reduced bonding strength of film layer, easy volatilization, etc., and achieve good The effect of biological activity, simple preparation process and stable chemical properties

Inactive Publication Date: 2007-03-14
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the plasma spraying method uses hydroxyapatite powder, which is melted by high-temperature plasma to make the particles adhere to the substrate. Since the particles are easily volatilized after being heated at high temperature, the composition of the formed film is difficult to control.
The ion beam sputtering method is to prepare hydroxyapatite by ion beam sputtering, and the overall content of the film is difficult to control
Although the sol-gel method is easy to control the chemical composition and microstructure of the film, it requires post-treatment of high temperature annealing, which affects the properties of the matrix material
The micro-arc oxidation composite process generally has unfavorable factors such as increasing the complexity of the process and weakening the adhesion of the film layer; for example, micro-arc oxidation combined with hydrothermal treatment can transform and precipitate HA, but the bonding strength of the film layer is reduced by 40%; electrophoretic deposition uses electric field The effect makes HA deposited on the metal surface, but due to the loose combination, subsequent sintering treatment is required, which not only reduces the adhesion of the film layer, but also weakens the biological activity of the material during the sintering process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Use distilled water to prepare a solution containing 0.01 mol / L of sodium hexametaphosphate, 0.01 mol / L of sodium β-glycerophosphate, 0.45 mol / L of calcium acetate, and 0.01 mol / L of strontium chloride. With titanium as the anode and stainless steel or titanium as the cathode, DC power is used for micro-arc oxidation. The voltage is 300-500V; keep the electrolyte temperature not higher than 50°C. The micro-arc oxidation time is 5min, and a porous layer with a thickness of about 20 μm is formed on the titanium surface; X-ray diffraction analysis shows that the film layer is mainly composed of hydroxyapatite and strontium-containing hydroxyapatite Ca 10-X Sr X (PO 4 ) 6 (OH) 2 (in the formula, X is between 0 and 3), EDS shows that the ratio of strontium / calcium element in the film layer is 0.6%, the bonding strength of the film layer is 43MPa, and has good biological activity.

Embodiment 2

[0024] Use distilled water to prepare a solution containing 0.15 mol / L of sodium β-glycerophosphate, 0.2 mol / L of calcium chloride, and 0.05 mol / L of strontium acetate. Use titanium alloy sheet as anode, stainless steel or titanium as cathode, and use DC power supply for micro-arc oxidation. The voltage is 200-400V; keep the electrolyte temperature not higher than 50°C. The micro-arc oxidation time is 30min, and a porous layer with a thickness of about 33μm is formed on the titanium surface; X-ray diffraction analysis shows that the film layer is mainly composed of hydroxyapatite and strontium-containing hydroxyapatite Ca 10-X Sr X (PO 4 ) 6 (OH) 2 (in the formula, X is between 4 and 6), EDS shows that the ratio of strontium / calcium element in the film layer is 9.6%, the binding strength is 37MPa, and has good biological activity.

Embodiment 3

[0026]Use distilled water to prepare a solution containing 0.02 mol / L of sodium dihydrogen phosphate, 0.2 mol / L of calcium nitrate, 0.05 mol / L of strontium acetate, and 0.05 mol / L of strontium oxalate. The titanium alloy sheet is used as the anode, and the stainless steel or titanium is used as the cathode, and a DC pulse power supply is used for micro-arc oxidation. The voltage is 250-450V, the frequency is 300Hz, and the duty ratio is 55%; the electrolyte temperature is kept at 30-50°C. The oxidation deposition time is 60min; a porous layer with a thickness of about 28μm is formed on the titanium surface; X-ray diffraction analysis shows that the film layer is mainly composed of hydroxyapatite and strontium-containing hydroxyapatite Ca 10-X Sr X (PO 4 ) 6 (OH) 2 (where X is between 4 and 6), EDS shows that the ratio of strontium / calcium element in the film layer is 26.3%, and the bonding strength of the film layer is 33MPa, which has good biological activity.

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Abstract

The invention relates to the means of active biological film, especially the titanium radicel porous nanometer Strontium hydroxyapatite active biological film and the Process for the manufacture. The differential arc oxidation technology is used in the method, the film is generated in the surface of titanium and titanium alloy, a electrolyte solution with phosphate radical ion, calcium ion and Strontium ion is supplied; the titanium and titanium alloy is the anode and the rustless steel or the titanium is the cathode, the direct current power supply or the direct current impulsing power source is applied to differential arc oxygenize the titanium and titanium alloy; the oxidate time is 3-60min; the temperature of electrolyte is not above 50DEG C. There is no interface between the porous hydroxyapatite containing Strontium film produced by the invention and the basal body, the modulus of elasticity is approximate with the sclerotin, the porous hydroxyapatite containing Strontium film produced by the invention which has perfect bioactivity can be the alternate material of several parts with heavy load, such as femur, hip joint and teeth root.

Description

technical field [0001] The invention relates to a method for preparing a biologically active film layer on the surface of a medical metal material, in particular to a titanium-based porous nanometer-containing strontium-containing hydroxyapatite bioactive film layer and a preparation method thereof. Background technique [0002] In recent years, the development and application of various biomedical materials have developed rapidly, among which metal materials were the first to be used. Metal biomaterials generally have high strength and toughness, and are suitable for hard tissue repair and fixation. Commonly used metallic biomaterials include cobalt injection. However, due to the surface hardness of titanium and titanium alloys, low-base alloys, tantalum, titanium and titanium alloys, etc., among them, titanium and its alloys have excellent corrosion resistance, high specific strength, good biocompatibility and are suitable for implantation. It has...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/54A61L27/56A61L27/58
Inventor 王迎军黄勇宁成云南开辉
Owner SOUTH CHINA UNIV OF TECH
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