The invention discloses an interference suppression based cell admission control method of a D2D communication system. A terminal of the D2D communication system comprises a honeycomb network terminal (CUE) and a D2D mobile terminal (DUE). The method comprises the steps of (1) initializing system parameters, including the signal-to-noise ratio threshold, the power of a D2D emission terminal, and the CUE signal strength received by a base station; (2) acquiring the quantity of DUE pairs in the network and the distance of the terminals; (3) updating the interference parameter value in the network, and calculating the radius of a protecting area; (4) determining whether the DTUE to be accessed to the network is in a CUE suppression area; if so, entering step 7; (5) determining whether all DUE meet the communication service quality requirement after new DUE pairs accesses the network; if not, entering step 7; (6) accessing new DUE pairs to the network, and updating the quantity of the new DUE; (7) finishing the method. With the adoption of the method, the extra interference can be effectively removed, the new call blocking rate can be reduced, the network capacity can be improved, outstanding performances are achieved, and the implementation is easily carried out.