2 results about "Homocystinuria" patented technology

Methods and compositions relating to the engineering of modified proteins having homocysteine ​​activity are described. For example, a modified cystathionine-γ-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading homocysteine ​​is disclosed. Furthermore, compositions and methods for treating homocysteine ​​depletion or hyperhomocysteinemia using the disclosed enzymes or nucleic acids are provided.

Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.