4 results about "Protein regulation" patented technology

The invention discloses a heterocyclic compound, a pharmaceutical composition and application thereof. Provided is a heterocyclic compound, or a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a tautomer thereof, a polymorph thereof, a solvate thereof, an isotope derivative thereof, or a prodrug thereof; the compound has a structure as shown in a formula (I). . The heterocyclic compound provided by the invention has inhibitory activity on TEAD protein, can effectively inhibit interaction of TEAD and YAP, and further can treat diseases related to abnormal TEAD protein regulation or abnormal Hippo pathway.

The invention belongs to the technical field of respiratory disease targeted therapy and protein regulation and control, and relates to application of an ACTN2 protein enhancer in preparation of a medicine for preventing, relieving or treating asthma. The key'switch 'effect of the cytoskeleton protein ACTN2 in airway smooth muscle cell (ASMC) phenotype transformation is discovered and confirmed for the first time. The prior art mainly focuses on inflammatory pathways or bronchial relaxation, while the invention reveals that the expression down-regulation of ACTN2 is a key driving factor which causes the conversion of ASC from a resting systolic phenotype to a pathological synthetic phenotype. The discovery provides a brand new therapeutic target for asthma, especially refractory asthma accompanied by severe airway remodeling and hormone resistance.

This invention discloses a triazole compound, its preparation method, and its applications. The triazole compound is of formula I. The triazole compound provided by this invention exhibits strong binding activity to TEAD protein. After binding to TEAD protein, the compound significantly enhances the protein's thermal stability while inhibiting TEAD protein activity. It effectively disrupts the TEAD-YAP interaction and demonstrates strong anti-proliferative activity against the NCI-H226 cell line with abnormal Hippo pathway NF2 deficiency, thereby enabling the treatment of diseases related to abnormal TEAD protein regulation or Hippo pathway abnormalities.