1 results about "Protein regulation" patented technology

This invention discloses a triazole compound, its preparation method, and its applications. The triazole compound is of formula I. The triazole compound provided by this invention exhibits strong binding activity to TEAD protein. After binding to TEAD protein, the compound significantly enhances the protein's thermal stability while inhibiting TEAD protein activity. It effectively disrupts the TEAD-YAP interaction and demonstrates strong anti-proliferative activity against the NCI-H226 cell line with abnormal Hippo pathway NF2 deficiency, thereby enabling the treatment of diseases related to abnormal TEAD protein regulation or Hippo pathway abnormalities.