The invention discloses a smart medicine chest. The medicine chest comprises a control module and a medicine chest body, wherein the medicine chest body is internally provided with a plurality of medicine grids, partition plates are arranged between the horizontal medicine grids, stand columns are arranged at the front ends of the partition plates, and LED indicator lights are arranged in the stand columns; the control module comprises an information processing module, an information collecting module, a database and a general controller, wherein the information processing module comprises a main control unit and a data computing unit. Compared with the prior art, the smart medicine chest has the beneficial effects that the problem that a user cannot take medicines accurately according to quantity in time can be solved, and the use function of the medicine chest can be added through the multi-dimension reminding functions including LED light indication, voice prompt and display of a display screen, so that the user can acquire the medicine taking information in time, and can fetch the medicines accurately under the guiding of the LED light, and therefore, convenient in use is achieved.