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Novel orthopaedics medicaments carrier system and preparation thereof

A carrier system and drug technology, applied in drug delivery, drug combination, pharmaceutical formulation, etc., can solve the problems of slow degradation, no osteoconductivity and osteoinductivity, and incomplete degradation, and achieve high reactivity and good bioavailability Degradability, effects of good biocompatibility

Active Publication Date: 2008-09-10
深圳市中科海世御生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the 1970s, Klemm invented polymethyl methacrylate (PMMA) bone cement containing gentamicin and achieved certain curative effect in the treatment of osteomyelitis. However, the bonding of PMMA bone cement is an exothermic process and the temperature is high, so it can only be used for high temperature resistance. limited doses of antibiotics
Calcium phosphate bone cement is a kind of inorganic material mainly composed of various calcium phosphate salt powders. It has good biocompatibility, but this type of material is not osteoinductive, and the degradation rate is slow and cannot be fast. replaced by new bone
In 2005, Chinese patent CN1686557A disclosed the method of using calcium sulfate as a drug carrier. This type of material has good biocompatibility, and has a faster degradation rate than calcium phosphate materials, and does not require secondary surgery to remove the carrier, but Not osteoconductive and osteoinductive, the implant site is still defective, still a weak part of the bone
In 2001, U.S. Patent USP6197342 disclosed a preparation method of a drug sustained-release system using bioactive glass ceramics as a matrix. This type of material has good osteoinductivity, but it mainly uses silicon oxide as the main body of the network, and it degrades slowly in vivo, and It cannot be completely degraded, and the preparation process is more complicated than bone cement

Method used

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  • Novel orthopaedics medicaments carrier system and preparation thereof
  • Novel orthopaedics medicaments carrier system and preparation thereof
  • Novel orthopaedics medicaments carrier system and preparation thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0038] Example 1 Bioactive glass-based vancomycin drug carrier

[0039] Use analytical pure Na 2 CO 3 , CaCO 3 , H 3 BO 3 , Na 2 HPO 4 As raw materials, prepare batch materials according to the glass composition in Table 1. After mixing the batch materials uniformly, melt them in a platinum crucible at 1100~1150°C for 2 hours to obtain bubble-free glass liquid, and finally quench the molten glass , To obtain a transparent crystal-free glass block. Crush the block, grind and sieve the glass powder between 25 and 50 μm.

[0040] Table 1 The chemical composition of bioactive glass

[0041]

[0042] In addition, 40 mg of vancomycin was dissolved in 0.2 ml of phosphoric acid curing buffer, stirred well, and 1 g of sieved glass powder was added, and the mixture was stirred evenly and then filled into the mold. Press 10MPa for 15s, after demolding, put it into the environment with humidity>95% and temperature at 37℃ for 5h to obtain the drug carrier. The strength of the drug carrier is...

Embodiment 2

[0045] Example 2 Bioactive glass-based rifampicin drug carrier

[0046] Use analytical pure Na2CO3, CaCO3, H3BO3, SiO2, Na 2 HPO 4 As raw materials, batch materials were prepared according to the glass composition shown in Table 2. After mixing the batch materials uniformly, melting them in a platinum crucible at 1200-1250°C for 2 hours to obtain a bubble-free glass solution, and finally quenching the molten glass solution to obtain a transparent crystal-free glass. Grind and sieve glass powder between 25 and 50 μm. Mix 40 mg of rifampicin with 700 mg of glass powder thoroughly, drop in 0.2 ml of phosphoric acid curing buffer, stir well and fill it into the mold. No pressure is applied, free forming. Put the mold into an environment with a humidity of >95% and a temperature of 37° C. for aseptic curing for 5 hours, and demold the mold to obtain a drug carrier. The drug strength is 15-20MPa.

[0047] Table 2 Chemical composition of bioactive glass

[0048]

[0049] Dry the drug c...

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Abstract

The invention discloses a degradable orthopedics drug carrier system with osteo inductivity and a preparation method thereof. The drug carrier system essentially consists of the carrier material which is biological activity glass setting solid and the carried therapeutic drug. And the carrier material is the solid body carrier material with certain strength which is obtained through the fast curing after the reaction of highly reactive boron-containing biological activity glass and cured buffer liquid after the reaction. The carrier material can carry various drugs without thermal stability restriction, such as antibiotics, bone growth factors, antituberculosis drugs, antineoplastic drugs, which are used for the treatment of orthopedics diseases, thus composing the integrated drug carrier system. The drug carrier system can degrade automatically under the function of human tissue fluid in a human body with a porous structure left during the degradation which provides diffusion channels for the sustainable releasing of the drugs, thus achieving the effect that the drugs are chronically and uniformly released. The drug carrier system has good biocompatibility, biological activity and osteo inductivity and can be applied to the treatment of various diseases of orthopedics.

Description

Technical field [0001] The invention belongs to the field of biomaterials, and relates to an orthopedic drug carrier system with osteoinductivity and complete degradability and a preparation method thereof. Background technique [0002] The implantable drug slow-release system is to load the drug into a certain carrier, and then directly implant the drug carrier into the infected area. Through the special structure of the carrier (usually there are two structural forms of integral type and reservoir type), continuous and uniform It is a method to release drugs locally and for a long time to kill the target bacteria. This method can avoid the shortcomings of multiple administrations and large fluctuations in the drug release rate, so that the drug can reach and continue to a higher concentration at the target site, and the non-drug site maintains a lower systemic blood drug concentration, thereby eliminating the traditional In the treatment, systemic medication causes toxic and si...

Claims

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Application Information

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IPC IPC(8): A61K47/04A61K47/02A61K45/08A61K9/00A61P19/08
Inventor 黄文旵王德平周萘姚爱华刘欣
Owner 深圳市中科海世御生物科技有限公司
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