Degradable dynamics enhancement type bioglass radical porous composite material and preparation method thereof

Abstract

The invention relates to a biological glass base porous composite material of a degradable mechanical enhanced type and a preparation method thereof. The material takes a biological glass porous stent which comprises macroporous channels and mediated pore channels as matrix. Adjacent macroporous channels are mutually communicated. The internal and external surfaces of the macroporous channels and mediated pore channels are provided with gel layers which are assembled layer-to-layer by the biomolecules with positive and negative charges alternatively. The biological glass matrix is made from the components with the following weight percentage of 16-38 percent of CaO, 0-10 percent of P2O5, 45-80 percent of SiO2, 0-0.1 percent of SrO and 0-22.5 percent of Na2O. The releasing speed of the biological active ions of the biological glass base porous composite material which is similar to the extracellular matrix and is decorated by the layer-to-layer assembly of the charges of different polarity of the biomolecules can be effectively cut and controlled. The walls of the pore channels are beneficial to the adhesion growth of cells. The mechanical strength, the fracture toughness and the machinability are good. And the application of the regeneration treatment on the bone gear injury home position of a stress concentrated part can be satisfied.

Description

technical field [0001] The invention relates to a degradable mechanically enhanced biological glass-based porous composite material used for in-situ regeneration and repair of human bone and tooth tissue damage and tissue engineering cell scaffold and a preparation method thereof, belonging to the technical field of biomedical materials. Background technique [0002] The rapid and complete regenerative repair of a series of bone defects such as bone and tooth tissue necrosis caused by tumors and inflammation, bone loss and fractures caused by osteoporosis, and bone and tooth defects caused by mechanical force is a difficult problem in clinical medicine. Professor Larry L. Hench first discovered a kind of CaO, SiO 2 ,P 2 o 5 and Na 2 The glass powder fired from the compound of the O component induces the deposition of bone-like apatite in the body fluid or simulated body fluid, and can form a bone chemical bond with the living bone and tooth tissue, and develop into a bone...

AI Technical Summary

Problems solved by technology

The uniform distribution of each component of this material also restricts the controllable release of active substances. The high specific surface properties determine that the active substances will degrade too quickly in a short period of time, which will inevitably lead to decreased cell activity, rapid aging and apoptosis. This material is directly used in Prospects for clinical repair are low

Chinese patent 200580030278.2 discloses a method for preparing porous materials with high compressive strength from bioactive glass powder, but the degradability of fully crystallized porous ceramics prepared by high temperature sintering is slow, and the mechanical test specimen (diameter × height: ) is significantly different from the scale standard (diameter<height) of related material samples at home and abroad, and a higher compressive strength can only be obtained under the premise of sacrificing porosity (40%) and pore penetration rate

[0006] In order to improve the mechanical properties of bio-glass porous materials, organic-inorganic hybrid technology is widely used at home and abroad to prepare porous bio-glass composite materials, but the improvement of its mechanical properties has not achieved a fundamental breakthrough (Rezwana K et al., Biomaterials.2006; 27: 3413)

There are two outstanding problems in the existing preparation technology: first, micron-sized particle powder is often used in the construction of bioactive glass porous bulk materials, and the force transmission of particles on the micro-nano scale is quite limited, so the compressive strength is still very low ( ~3MPa); Second, in the selection of organic components in organic-inorganic hybrid design, only basic indicators such as biocompatibility are paid attention to, and the strong interaction factors between inorganic-organic at the nanometer level or even the molecular level are not taken seriously; There is a big difference in the properties of organic molecules and bioglass. The poor compatibility of the two results in low interface bonding strength. The polymer matrix shrinks and deforms on the surface of the bioglass, and microcracks occur at the interface of the two phases, resulting in poor mechanical properties.

It is especially important that in the traditional organic-inorganic hybrid design, the inorganic components become dispersed or local aggregates, and the external force produces stress concentration, which leads to the failure of the organic-inorganic interface of the material and premature failure of the microstructure, improving the mechanical properties of the composite material. fairly limited effect

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