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Degradable zwitterionic polymer with biological associativity and preparation method thereof

A zwitterion, bioassociation technology, which is applied in the types of packaging items, special packaging items, medical containers, etc., can solve the problems of hindering application, unable to have biocompatibility, degradability and bioassociation at the same time, To achieve the effect of mild conditions, excellent anticoagulant and biocompatibility, and simple process

Active Publication Date: 2013-12-25
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The polymers prepared in the above-mentioned published documents all have excellent biocompatibility, but cannot simultaneously possess biocompatibility, degradability and bioassociation, thus hindering their further development in the fields of biology and medicine. application

Method used

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  • Degradable zwitterionic polymer with biological associativity and preparation method thereof
  • Degradable zwitterionic polymer with biological associativity and preparation method thereof
  • Degradable zwitterionic polymer with biological associativity and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Add 50mL of anisole and 20mL of methanol into the polymerization tube, then add 2.5g of 2-methacryloyloxyethylphosphorylcholine, 2.5g of N-hydroxysuccinimide methacrylate, 45g of 2-methylene- 1,3-Dioxetane and 5g of azobisisobutyronitrile, deoxygenated by nitrogen gas for 30 minutes, put into an oil bath at 60°C to react for 24 hours, after taking out, concentrate the solvent, and then precipitate with petroleum ether to obtain The product was dried in a vacuum oven at 40 °C for 24 h. The polymerization process is shown in the following formula:

[0038]

[0039] figure 1 The H NMR spectrum of the polymer prepared for this embodiment, the NMR characteristic peaks of each unit of the copolymer have been marked in the figure, which proves the successful synthesis of the polymer.

[0040] figure 2 The gel permeation chromatogram of the polymer prepared for this example shows that the molecular weight of the prepared polymer is 28000, and the molecular weight distrib...

Embodiment 2

[0042] Add 100mL of acetonitrile into the polymerization tube, then add 4.5g of [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfonic acid propyl)ammonium hydroxide, 2g of methacrylic acid N-hydroxy Succinimide ester, 60g of 2-methylene-1,3-dioxolane and 0.08g of di-tert-butyl peroxide, after deoxygenation by nitrogen gas for 30 minutes, put them in an oil bath at 150°C for 12 hours , after taking it out, concentrate the solvent, then precipitate with petroleum ether, and dry the obtained product in a vacuum oven at 40°C for 24h. The polymerization process is shown in the following formula:.

[0043]

Embodiment 3

[0045]Add 100mL of ethanol and 250mL of benzene into the polymerization tube, then add 40g of [2-(methacryloyloxy)propyl]dimethyl-(3-carboxylate ethyl) ammonium hydroxide, 10g of acrylic acid N-hydroxy Succinimide, 200g of 2-methylene-1,3-dioxycyclohexane and 5g of dimethyl azobisisobutyrate, after deoxygenation with nitrogen gas for 30 minutes, put them into an oil bath at 110°C for reaction After 8 hours, the solvent was concentrated and precipitated with petroleum ether, and the obtained product was dried in a vacuum oven at 40°C for 24 hours. The polymerization process is shown in the following formula:

[0046]

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PUM

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Abstract

The invention discloses a degradable zwitterionic polymer with biological associativity. The degradable zwitterionic polymer is prepared by copolymerizing the following materials in parts by weight by taking the total mass of monomers as 100 parts: 50-90 parts of a cyclo-ketene acetal monomer, 1-15 parts of an active ester monomer and 5-40 parts of a zwitterionic monomer. The invention also discloses a preparation method of the degradable zwitterionic polymer with biological associativity, wherein the prepared copolymer has ester groups which ensure that the copolymer can be completely degraded, amphoteric ions which ensure that the copolymer has excellent anticoagulant activity and biocompatibility, and active ester which endows the copolymer with the biological associativity. The copolymer integrates the characteristics of the three monomers, is adjustable and controllable in composition ratio, has multiple functions, and can be used for preparation and surface modification of biological medical materials.

Description

technical field [0001] The invention relates to the field of polymer preparation, in particular to a bioassociated degradable zwitterionic polymer and a preparation method thereof. Background technique [0002] In the 21st century, which cares more about human health, with the rapid development of modern medicine, polymer materials are more and more widely used in the field of biomedicine, which also puts forward higher and higher requirements for polymer materials. [0003] Biomedical polymer materials must be in contact with physiological systems (blood, tissues, cells, etc.) or their components (proteins, enzymes, DNA, polysaccharides, inorganic salts and various small biological molecules) during use, requiring them Tissues will not cause inflammation or foreign body reactions, so they must have good biocompatibility and blood compatibility; when the polymer is used in the fields of in vivo sutures and tissue engineering scaffolds, it needs to be degradable. [0004] In...

Claims

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Application Information

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IPC IPC(8): C08G63/692C08G63/688C08G63/685C08F230/02C08F220/36C08F220/38C08F220/22C08F220/18C08F220/34A61L33/06
Inventor 计剑金桥蔡童姜
Owner ZHEJIANG UNIV
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