A stimulus-responsive polypyrrole nanotube targeting drug carrier and its preparation method
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A polypyrrole nanotube and stimuli-responsive technology, applied in the field of targeted drug carrier nanomaterials, can solve problems such as drug leakage, nanogel drug leakage, and uneven particle size.
Active Publication Date: 2018-03-27
CENT SOUTH UNIV
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Problems solved by technology
The micelles, vesicles, and nanogels formed by a large number of researched block copolymers are prone to drug leakage, drug leakage, and uneven particle size.
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Embodiment 1
[0060] (1) In 10ml of pyrrole monomer and 17.29g of sodium hydroxide aqueous solution, 0.48g of tetrabutylammonium bromide, 16ml of 1,3-dibromopropane, react for 12h, after the reaction is complete, suction filter, add a small amount of dichloromethane to dissolve , washed with saturated brine, spin-dried the solvent, and distilled under reduced pressure to obtain 1-(3-bromopropyl)pyrrole.
[0061] (2) Preparation of template
[0062] The titanium sheet is mechanically polished, deoiled and degreased, the titanium sheet is used as the anode, the platinum sheet is used as the cathode, 0.18g NH 4 F, 3ml water, 0.3mlH 2 SO 4 Ethylene glycol electrolyte, temperature 0°C, 180V constant voltage DC power supply for anodizing for 8 minutes, and the prepared titanium dioxide nanotubes were rinsed with distilled water to clean the surface electrolyte for later use. figure 2 and image 3 Its scanning electron microscope image.
[0063] The titanium sheet is mechanically polished, d...
Embodiment 2
[0083] (1) Pyrrole modification
[0084] Slowly add 10ml of pyrrole monomer dropwise to 35ml of 50% sodium hydroxide aqueous solution, 4.8g of tetrabutylammonium bisulfate, 110ml of 1,2-dichloroethane, heat and reflux for 24 hours, dilute with water after the reaction, Dichloromethane was extracted, combined with dichloromethane, washed with water three times, dried over anhydrous sodium sulfate, and spin-dried to obtain 1-(2-chloroethyl)pyrrole. Other steps are the same as in Example 1.
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Abstract
The invention provides a stimulus-response type polypyrrole nanotube targeting drug carrier and a preparation method. A titanium dioxide nanotube array or a porous anodic alumina array serves as a template, and a polypyrrole nanotube is prepared through chemical vapor deposition; beta-cyclodextrin and a tube opening of a polypyrrole nanotube are connected through stimulus response type sensitive bonds such as acyl hydrazone bonds and disulfide bonds, and medicine can be blocked in the nanotube and released out in the faintly acid and reducibility environments; one end of a polyethylene glycol chain is connected with a folic acid targeted molecule, the other end of the polyethylene glycol chain is connected with an adamantane head base, the adamantane head base is linked up to a beta-cyclodextrin hydrophobic cavity through host and guest envelope, and folic acid molecules recognize tumor cells through a receptor-ligand medium. The stimulus-response type polypyrrole nanotube targeting drug carrier prepared through the method is uniform in particle diameter size distribution, controllable in appearance, stable in product, simple in synthesis process, low in cost and suitable for mass production.
Description
technical field [0001] The invention relates to the field of targeted drug carrier nanomaterials, in particular to a stimulus-responsive targeted drug carrier and a preparation method. Background technique [0002] In recent years, cancer is a disease that seriously affects human health. Traditional anticancer drugs attack normal cells while killing tumor cells. How to release anticancer drugs only in tumor tissue without affecting normal cells is a hot issue that needs to be solved urgently. Polypyrrole is a C, N five-membered hybrid conjugated conductive polymer, usually an amorphous black solid. Polypyrrole is non-toxic and has good biocompatibility. It has important applications in biological tissue engineering fields such as stimulating nerve cell growth, bone cell regeneration, cell behavior control, vascular grafts, biological scaffolds, protein separation and DNA adsorption, and biosensing (George P M, Lyckman A W, LaVan D A, et al. Fabrication and biocompatibility...
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