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A slow-release double-layer oral ulcer film and its preparation method

An oral ulcer, slow-release technology, applied in the field of slow-release double-layer oral ulcer film and its preparation, can solve the problem of increasing the mechanical support and friction of ulcer and oral mucosa, the adhesion time of oral ulcer film needs to be improved, and unfavorable oral cavity Ulcer patient recovery and other problems, to achieve the effect of isolating saliva and external erosion, good bioadhesion, and prolonging the action time

Active Publication Date: 2019-12-27
HARBIN QIANBAINA BIOPHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The double-layer patch of this patent improves the utilization rate of the drug to a certain extent, but the directional release effect needs to be improved, and the tablet will increase the mechanical support and friction on the ulcer and oral mucosa during use, reducing the comfort of the patient. The double-layer adhesive sheet is prepared by spraying film, the protective layer is prone to gaps, and the waterproof effect is not good
[0008] Chinese patent application CN 107412200 A discloses a bioadhesive slow-release oral ulcer film and its preparation method. -80%, drug 0.5-10%, support agent 1-50%, plasticizer 1-20%, bacteriostatic agent 0.1-0.5%, flavoring agent 0.5-1%, this patent has a certain slow-release effect, To a certain extent, the action time is prolonged, but the patent only involves a layer of film, and the directional release effect of the drug is poor during use, resulting in a low drug utilization rate, and the adhesion time of the oral ulcer film needs to be improved, which is not conducive to the treatment of oral ulcer patients. recover

Method used

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  • A slow-release double-layer oral ulcer film and its preparation method
  • A slow-release double-layer oral ulcer film and its preparation method
  • A slow-release double-layer oral ulcer film and its preparation method

Examples

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Effect test

Embodiment 1

[0063] A slow-release double-layer oral ulcer film, which has a double-layer structure, one layer is a slow-release drug-loaded layer, and the other layer is a waterproof protective layer. The slow-release drug-loaded layer in the finished product is composed of the following components in weight percentage: gelatin 10%, silver nitrate 0.5%, sodium methyl p-hydroxybenzoate 0.1%, stevioside 0.5%, propylene glycol 1%, water balance, and the waterproof protective layer is composed of the following components by weight percentage: corn protein 25%, sesame oil 5% %, the mass fraction is the balance of 80% ethanol.

[0064] The preparation method of oral ulcer membrane comprises the steps:

[0065] (1) Mix 1g of propylene glycol and 89g of water, add 10g of gelatin into the mixed solution of propylene glycol and water, heat and stir at a heating temperature of 70°C, a rotation speed of 30r / min, stirring for 30min, and cool down to 25°C to obtain solution A;

[0066] (2) Add 0.5 g o...

Embodiment 2

[0071] A slow-release double-layer oral ulcer film, which has a double-layer structure, one layer is a slow-release drug-loaded layer, and the other layer is a waterproof protective layer. The slow-release drug-loaded layer in the finished product is composed of the following components in weight percentage: Promellose 50%, levamisole hydrochloride 15%, potassium sorbate 0.5%, acesulfame 2%, polysorbate 5% and water balance, waterproof protective layer is made up of the following components by weight percentage: ethyl cellulose Sodium 80%, triethyl citrate 10% and ethyl acetate balance.

[0072] The preparation method of oral ulcer membrane comprises the steps:

[0073] (1) Mix 5g of polysorbate and 45g of water, add 50g of hypromellose into the aqueous solution of polysorbate, heat and stir at a heating temperature of 80°C, a rotating speed of 70r / min, stirring for 60min, and cooling to 50°C to obtain a solution A;

[0074] (2) Add 15 g of levamisole hydrochloride, 0.5 g of...

Embodiment 3

[0079] A slow-release double-layer oral ulcer film, which has a double-layer structure, one layer is a slow-release drug-loaded layer, and the other layer is a waterproof protective layer. The slow-release drug-loaded layer in the finished product is composed of the following components in weight percentage: slow-release drug-loaded layer 30% film-forming material, 7% chlorhexidine gluconate, 0.3% nisin, 1% sodium saccharin, 3% plasticizer I and the rest of water, and the waterproof protective layer is composed of the following components by weight percentage: poly Vitamin ketone 50%, plasticizer Ⅱ 8% and solvent Ⅱ balance.

[0080] Among them, the plasticizer Ⅰ is a mixture of propylene glycol and glycerol, and the mass ratio of the two is 1:1; the plasticizer Ⅱ is a mixture of castor oil and propylene glycol, and the mass ratio of the two is 1:2, and the solvent Ⅱ is the mass fraction It is a mixed solvent of 95% ethanol and ethyl acetate, and the mass ratio of the two is 3:...

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Abstract

The invention relates to a dental ulcer membrane, in particular to a slow release type dual-layer dental ulcer membrane and a preparation method thereof. The dental ulcer membrane has a dual-layer structure, one layer is a slow-release medicine carrying layer, the other layer is a waterproof protecting layer, and the slow-release medicine carrying layer comprises the following components of a slow-release membrane formation material, medicines, a bacteriostat, a correctant, a plastifier I and a solvent I. The slow release type dual-layer dental ulcer membrane disclosed by the invention has remarkable characteristics of being long in adhesion time, and capable of preventing the medicines from being released in an opposite direction and isolating saliva and outside invasion for a long time.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a sustained-release double-layer oral ulcer film and a preparation method thereof. Background technique [0002] The oral cavity is the external environment of the teeth, and its main functions are to secrete saliva and serve as a place for retention, chewing and swallowing of food taken from the outside world. At the same time, there are microorganisms symbiotic with the host in the oral cavity, forming a tiny ecosystem with the oral environment. Under normal physiological conditions, the micro-ecosystem in the oral cavity is stable and can resist the influence of the outside world on this environment. However, when there is an oral ulcer in the oral cavity, external microorganisms infecting the wound will aggravate the inflammation and deterioration of the wound and affect daily life. [0003] Oral ulcer, commonly known as "oral sore", is a common ulcerati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K47/42A61K47/44A61P1/02A61K33/38A61K31/429A61K31/155
CPCA61K9/006A61K31/155A61K31/429A61K33/38A61K47/42A61K47/44A61P1/02
Inventor 高纳新
Owner HARBIN QIANBAINA BIOPHARM
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