Method for preparing medical wound dressing by microfluidic gas jet spinning method

A wound dressing and spinning technology, applied in the field of medical polymer materials, can solve the problems of poor healing effect, uneven fiber diameter, single composition, etc., and achieve the effect of promoting wound healing, strengthening regeneration ability, and blocking bacteria

Active Publication Date: 2021-06-08
NANUS NEW MATERIAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional nanofibrous scaffold materials are usually prepared by electrospinning technology, but they can only be used for small wounds with a single composition and uneven fiber diameters, resulting in unremarkable healing effects

Method used

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  • Method for preparing medical wound dressing by microfluidic gas jet spinning method
  • Method for preparing medical wound dressing by microfluidic gas jet spinning method
  • Method for preparing medical wound dressing by microfluidic gas jet spinning method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 16g thermoplastic polyurethane (purchased from BASF) was dissolved in 84g N,N-dimethylformamide to form a polymer A solution with a mass fraction of 16%, and 4.5g zinc acetate was added to the polymer A solution to form a 4.5wt% mixed solution. Transfer the mixed solution into a syringe fitted with a metal needle. 5g of tannic acid was dissolved in 95g of N,N-dimethylformamide to form a polymer B solution with a mass fraction of 5%, and 4.5g of zinc acetate was added to the polymer B solution to form a 4.5wt% mixed solution. Transfer the two mixed solutions of A and B to two 20ml syringes equipped with metal needles, and use a Y-shaped polydimethylsiloxane microfluidic chip with an inner diameter of 0.8mm to separate A and B Mixing, the output rate of the micro-flow pump is set to 5mL / h and 2mL / h respectively, the distance from the needle to the receiver is set to 35cm, the air pump blows the air out of the pinhole with a pressure of 0.1MPa, and the spinning time is 3h...

Embodiment 2

[0031] 15g polycaprolactone was dissolved in 85g 88% formic acid to form a mass fraction of 15% polymer A solution, 7g zinc nitrate hexahydrate was added to form a 7wt% mixed solution in polymer A solution, 10g chitosan was dissolved in 90g 88 % formic acid was dissolved uniformly to form a 10% polymer B solution, and 7g of zinc nitrate hexahydrate was added to the polymer B solution to form a 7wt% mixed solution. Transfer the two mixed solutions of A and B to two syringes equipped with metal needles, and use a T-shaped polydimethylsiloxane microfluidic chip with an inner diameter of 0.4mm to mix A and B during spinning , set the output rate of the micro-flow pump to 5mL / h and 5mL / h respectively, set the distance from the needle to the receiver to 30cm, the air pump blows air out of the pinhole at a pressure of 0.1MPa, and the spinning time is 2h , obtain the polycaprolactone / chitosan fiber scaffold on the receiver, the ambient temperature is 28°C, and the humidity is 60%. Th...

Embodiment 3

[0034]15g polycaprolactone was dissolved in 85g 88% formic acid to form a mass fraction of 15% polymer A solution, and 7g zinc nitrate hexahydrate was added to form a 7wt% mixed solution in polymer A solution; 12g silk fibroin was dissolved in 88g 88 % formic acid to form a polymer B solution with a mass fraction of 12%, and 7g of zinc nitrate hexahydrate was added to the polymer B solution to form a 7wt% mixed solution. Transfer the two mixed solutions of A and B to two syringes equipped with metal needles, and use a Y-shaped polydimethylsiloxane microfluidic chip with an inner diameter of 0.2mm to mix A and B during spinning , set the output rate of the micro-flow pump to 3mL / h and 5mL / h respectively, set the distance from the needle to the receiver to 28cm, the air pump blows air out of the pinhole at a pressure of 0.2MPa, and the spinning time is 4h , to obtain a polycaprolactone / silk fibroin composite fiber scaffold on the receiver. The ambient temperature is 30°C, the h...

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Abstract

The invention discloses a method for preparing medical wound dressing by a microfluidic gas jet spinning method. Specifically, a microfluidic method and a polymer gas jet spinning method are combined to prepare a nanofiber scaffold with high biocompatibility, high flexibility, high porosity and controllable diameter. An MOF nano array grows in situ on the obtained nanofiber scaffold, and the finally obtained medical wound dressing has the advantages of low cost, large-scale production, controllable diameter, good sterilization performance and capability of effectively promoting wound healing. The method has the advantages that extra energy does not need to be introduced in a preparation process to maintain forming of fibers and growth of functional factors, and components and morphology of the material can be effectively regulated and controlled through combination of a microfluidic chip and gas jet spinning. The whole preparation process is green, environmentally friendly, efficient and energy-saving; and the method can achieve large-scale production, and has a good industrial prospect.

Description

technical field [0001] The invention relates to the field of medical polymer materials, and relates to a method for preparing a medical wound dressing by a microfluidic air-jet spinning method. The scaffolds are functionally modified to achieve wound dressings that can effectively promote wound healing and skin regeneration. Background technique [0002] During the wound healing process, factors such as bacteria, microbial infection and ultraviolet radiation may cause complications, thereby prolonging the healing time of the wound. Wound dressings can prevent microbial penetration, sterilize and reduce inflammation, further protect open wounds, and promote wound healing and tissue regeneration. [0003] As a wound dressing, the nanofiber scaffold can provide a solid physical barrier for the wound, which can effectively prevent bacteria and external pollution from invading the wound. environment to heal. For nanofibrous scaffolds, the designability of materials and functio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D06M15/37D01F6/94D01F6/92D01F9/00D01F4/02D01F4/00D01D5/00A61L15/26A61L15/28A61L15/32A61L15/20A61L15/44A61L15/46D06M101/02D06M101/12D06M101/32D06M101/38
CPCD06M15/37D01F6/94D01F6/92D01F9/00D01F4/02D01F4/00D01D5/00A61L15/225A61L15/20A61L15/44A61L15/46D06M2101/32D06M2101/02D06M2101/12D06M2101/38A61L2400/12A61L2300/404A61L2300/412
Inventor 陈苏王浩鹏
Owner NANUS NEW MATERIAL
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