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Staphylococcus aureus phage suppository and application of staphylococcus aureus phage suppository in treatment of dairy cows

A staphylococcus and bacteriophage technology, applied in the direction of medical raw materials derived from viruses/phages, suppository delivery, local antibacterial agents, etc., can solve problems such as endangering sperm motility and embryo implantation, hindering the development of cattle breeding, and repeated infertility of dairy cows , to achieve the effect of improving drug utilization, reducing adverse reactions, and low cost

Pending Publication Date: 2022-05-13
PHAGELUX (NANJING) BIO-TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After dairy cows suffer from the disease, due to the inflammatory changes of the uterine mucosa, the influence of inflammatory products and bacterial toxins, it will cause sexual cycle disorder, endanger sperm motility and embryo implantation, and cause repeated infertility in dairy cows, which greatly hinders cattle breeding. industry development

Method used

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  • Staphylococcus aureus phage suppository and application of staphylococcus aureus phage suppository in treatment of dairy cows

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A kind of staphylococcus aureus phage suppository, this suppository is made up of the raw material of following mass percentage:

[0030] 65% of water-soluble base, 4% of phage stock solution, 6% of effervescent disintegrating agent, 15% of lubricant, 3% of foaming agent, 2% of resveratrol and 5% of traditional Chinese medicine auxiliary materials.

[0031] Wherein, the glycerin in the water-soluble matrix is ​​39%, the gelatin is 26%, the organic acid (citric acid, potassium hydrogen tartrate and tartaric acid) in the effervescent disintegrant is 2.8%, the carbon dioxide source (sodium bicarbonate and phosphoric acid) Sodium dihydrogen) is 1.2%, polyethylene glycol 400 is 10.5%, polyethylene glycol 6000 is 4.5% in the described lubricant, Tween-20 is 1.3%, Tween-60 is 1.3% in the described whipping agent 1.3%, 0.4% of sodium dodecylsulfonate, 1.25% of angelica, 1.25% of Chuanxiong, 1.25% of garlic and 1.25% of Houttuynia cordata in the auxiliary materials of traditiona...

Embodiment 2

[0033] A kind of staphylococcus aureus bacteriophage suppository, this suppository is made up of the raw material of following mass percentage:

[0034] 55% of water-soluble base, 3% of bacteriophage stock solution, 7% of effervescent disintegrant, 25% of lubricant, 3% of foaming agent, 2% of resveratrol and 5% of traditional Chinese medicine auxiliary materials.

[0035] Wherein, the glycerin in the water-soluble base is 33%, the gelatin is 22%, the organic acid (citric acid, potassium hydrogen tartrate and fumaric acid) in the effervescent disintegrant is 2.1%, the carbon dioxide source (sodium bicarbonate and potassium bicarbonate) is 0.9%, polyethylene glycol 400 in the lubricant is 17.6%, polyethylene glycol 6000 is 7.4%, Tween-20 is 1.3%, Tween-60 in the foaming agent 1.3%, 0.4% sodium dodecyl sulfonate, 1.25% Angelica, 1.25% Chuanxiong, 1.25% Scutellaria baicalensis and 1.25% Houttuynia cordata in the traditional Chinese medicine adjuvant materials.

Embodiment 3

[0037] A kind of staphylococcus aureus bacteriophage suppository, this suppository is made up of the raw material of following mass percentage:

[0038] 45% water-soluble base, 4% phage stock solution, 6% effervescent disintegrating agent, 35% lubricant, 3% foaming agent, 2% resveratrol and 5% traditional Chinese medicine adjuvant.

[0039] Wherein, the glycerin in the water-soluble base is 27%, the gelatin is 18%, the organic acid (citric acid, potassium hydrogen tartrate and tartaric acid) in the effervescent disintegrant is 4.2%, the carbon dioxide source (sodium bicarbonate and phosphoric acid) Sodium dihydrogen) is 1.8%, polyethylene glycol 400 is 24.7%, polyethylene glycol 6000 is 10.3% in the described lubricant, Tween-20 is 1.3%, Tween-60 is 1.3% in the described whipping agent 1.3%, 0.4% of sodium dodecylsulfonate, 1.25% of Angelica, 1.25% of Chuanxiong, 1.25% of Coptis Rhizoma and 1.25% of Houttuynia cordata in the traditional Chinese medicine auxiliary materials.

...

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Abstract

The invention discloses a staphylococcus aureus bacteriophage suppository and application thereof in treatment of dairy cows. The suppository is prepared from the following raw materials in percentage by mass: 25-75% of a water-soluble matrix, 1-4% of a bacteriophage stock solution, 5-10% of an effervescent disintegrant, 10-35% of a lubricant, 1-3% of a foaming agent, 1-2% of resveratrol and 2-5% of traditional Chinese medicine auxiliary materials. The effervescent suppository has the beneficial effects that the effervescent suppository, the resveratrol and a plurality of traditional Chinese medicine auxiliary materials are matched, and the synergistic or antagonistic effect of the effervescent suppository, the resveratrol and the traditional Chinese medicine auxiliary materials is utilized, so that the curative effect can be effectively improved or the adverse reaction can be reduced, the effects of clearing heat and promoting diuresis, promoting blood circulation and removing blood stasis, and sterilizing and diminishing inflammation can be achieved, and the symptom of dairy cow uterus bacterial vaginitis can be quickly relieved; and the medicine is low in cost, does not cause economic burden after being used for a long time, and is an ideal medicine for treating bacterial vaginitis.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a staphylococcus aureus phage suppository and its application in treating dairy cows. Background technique [0002] With the development of my country's national economy, people's living standards continue to improve, my country's dairy industry has developed rapidly, and the dairy industry has expanded on a large scale. There are currently four types of diseases that endanger the development of the dairy industry, namely nutritional and metabolic diseases, reproductive system diseases, breast diseases and hoof diseases. Infertility affects the reproduction of dairy cows, and cow endometritis is one of the important causes of infertility. After dairy cows suffer from the disease, due to the inflammatory changes of the uterine mucosa, the influence of inflammatory products and bacterial toxins, it will cause sexual cycle disorder, endanger sperm motility and e...

Claims

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Application Information

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IPC IPC(8): A61K9/02A61K36/8962A61K36/78A61P15/00A61P29/00A61P15/02A61P31/02A61P31/04A61K35/76A61K31/05
CPCA61K9/02A61K9/0034A61K35/76A61K31/05A61K36/232A61K36/236A61K36/8962A61K36/78A61K36/539A61K36/718A61K47/42A61P15/00A61P29/00A61P15/02A61P31/02A61P31/04A61K2300/00
Inventor 乔欢陈海徐旭凌黄杰费文斌刘墨胡怿林谢晓莉何四龙丛郁靳菊
Owner PHAGELUX (NANJING) BIO-TECH CO LTD
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