Absorbable polyurethane elastomer with high flexibility, high elasticity and controllable degradation as well as preparation method and application of absorbable polyurethane elastomer

A polyurethane elastomer, high elasticity technology, applied in prosthesis, medical formula, surgery, etc., can solve the problems of ineffective adjustment of degradation rate, long residence time, complex environment, etc., achieve controllable adjustment of degradation time, increase strength and Excellent toughness and biocompatibility

Active Publication Date: 2022-05-24
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the above materials all have different problems: polypropylene is non-degradable; polylactic acid-glycolic acid copolymer is not resistant to the corrosion of pancreatic juice; although polycaprolactone can withstand the corrosion of pancreatic juice, its residence time in the body (complete degradation requires 1 ~ more than 2 years) longer
At the same time, the degradation rate of polycaprolactone material cannot be effectively adjusted according to the time of patient wound healing, and because of its high crystallinity, the mechanical strength of the material reaches about 20MPa, and the hardness reaches about 75HA, which is not suitable for soft tissues. , may cause a certain degree of tissue damage after implantation
[0005] Through the introduction of polyols with different molecular weights and molecular structures, polyurethane can freely and flexibly adjust the hardness and mechanical properties of the material to meet the requirements of the material. Regulation is still very difficult
In addition, there are many kinds of biological enzymes such as protease, lipase and amylase in the organism, and the environment is very complex, which further increases the difficulty of regulating the biodegradation performance of materials, thereby limiting its application.

Method used

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  • Absorbable polyurethane elastomer with high flexibility, high elasticity and controllable degradation as well as preparation method and application of absorbable polyurethane elastomer
  • Absorbable polyurethane elastomer with high flexibility, high elasticity and controllable degradation as well as preparation method and application of absorbable polyurethane elastomer
  • Absorbable polyurethane elastomer with high flexibility, high elasticity and controllable degradation as well as preparation method and application of absorbable polyurethane elastomer

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preparation example Construction

[0035] A preparation method of a highly flexible, highly elastic, degradable and adjustable absorbable polyurethane elastomer, comprising the following steps:

[0036] Step 1: Add aliphatic random copolyester diol prepolymer and aliphatic polyester diol prepolymer into the reactor, remove water and dry under constant temperature and vacuum conditions; use an oil bath to keep the temperature constant , the water removal temperature is 30~60℃; the vacuum degree is kept at 0.06~0.12MPa; the water removal time is usually 3~8h. After the water removal is complete, the temperature is raised to above the melting point of the prepolymer under a protective atmosphere to melt and mix. The protective atmosphere is an inert gas, which can be high-purity nitrogen or helium.

[0037] Step 2: under a protective atmosphere, diisocyanate is added to the mixture obtained in step 1, and after sufficient reaction, an isocyanate-terminated prepolymer is obtained, and the reaction time is 1-3 hour...

Embodiment 1

[0047] A preparation method of a highly flexible, highly elastic, degradable and adjustable absorbable polyurethane elastomer, comprising the following steps:

[0048] Step 1: The aliphatic random copolyester diol prepolymer (HO-P(DO-c-δVL) with a number average molecular weight of 10.0kg / mol 50％ )-OH) and polycaprolactone prepolymer (HO-PCL-OH) with a number-average molecular weight of 1.4 kg / mol were added to the reactor at a mass ratio of 5:1, and dehydrated in an oil bath at 60 °C for 5 h under vacuum. Keep at 100Pa, after water removal, under nitrogen protection, melt and mix the prepolymer in an oil bath at 80°C;

[0049] Step 2: Under nitrogen protection, add 1,6-hexamethylene diisocyanate with a molar amount of terminal hydroxyl groups of 1.85 / 1 to the mixture obtained in step 1, and react in an oil bath at 80 °C for 3 hours to obtain an isocyanate-terminated pre-polymer. polymer.

[0050] Step 3: Under nitrogen protection, add the chain extender 1,4-butanediol with ...

Embodiment 2

[0052] A preparation method of a highly flexible, highly elastic, degradable and adjustable absorbable polyurethane elastomer, comprising the following steps:

[0053] Step 1: The aliphatic random copolyester diol prepolymer (HO-P(DO-c-δVL) with a number average molecular weight of 1.0kg / mol 42％ )-OH) and polyvalerolactone prepolymer (HO-PVL-OH) with a number-average molecular weight of 1.4 kg / mol were added to the reactor at a mass ratio of 1:10, and dehydrated in an oil bath at 60 °C for 5 h under vacuum. Keep at 100Pa, after water removal, under nitrogen protection, melt and mix the prepolymer in an oil bath at 80°C;

[0054] Step 2: Under nitrogen protection, add L-lysine diisocyanate with a molar amount of terminal hydroxyl groups of 4 / 1 to the mixture obtained in step 1. The isocyanate-terminated prepolymer was obtained after 3 h of reaction in an oil bath at 80°C.

[0055] Step 3: Under nitrogen protection, add chain extender 1,7-heptanediol with 3 / 1 molar amount of t...

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Abstract

The invention discloses an absorbable polyurethane elastomer with high flexibility, high elasticity and controllable degradation as well as a preparation method and application of the absorbable polyurethane elastomer. Comprising the following steps: step 1, adding an aliphatic random copolyester diol prepolymer and an aliphatic polyester diol prepolymer into a reactor, dewatering and drying, and after dewatering is completed, heating to above the melting point of the prepolymers in a protective atmosphere for melting and mixing; step 2, in a protective atmosphere, adding diisocyanate into the mixture, and fully reacting to obtain an isocyanate-terminated prepolymer; and 3, adding a chain extender into the isocyanate-terminated prepolymer under the condition of a protective atmosphere, and reacting to obtain the required absorbable polyurethane elastomer. The polyurethane obtained by the invention not only has the advantages of good biocompatibility, high flexibility, high elasticity, controllable degradation, absorbability and the like, but also can resist the corrosion action of various proteases such as pancreatic juice, bile and the like; the polyurethane elastomer can be used for digestive tract anastomosis medical equipment, biodegradable coatings of repair stents, soft tissue regeneration and repair medical products, degradable packaging materials, degradable sealing materials and degradable battery packaging materials.

Description

technical field [0001] The invention relates to the technical field of polyurethane elastomers, in particular to an absorbable polyurethane elastomer with high flexibility, high elasticity and controllable degradation, a preparation method and applications. Background technique [0002] Polyurethane is an emerging organic polymer material, known as the fifth largest plastic. The main raw materials for synthesizing polyurethane are polyisocyanates and terminal hydroxyl compounds. Due to different reaction conditions, different types of diisocyanates, different ratios of diisocyanates and terminal hydroxyl compounds, different types of hydroxyl terminal compounds, and different relative molecular weight and quality of terminal hydroxyl compounds, The structure and properties of polyurethane will be very different, which also makes polyurethane materials widely used in coatings, adhesives, thermoplastic elastomers, foam materials and other fields. Among them, polyurethane prep...

Claims

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Application Information

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IPC IPC(8): C08G18/12C08G18/66C08G18/42C08G18/32A61L31/14A61L31/06A61L27/58A61L27/34A61L27/18
CPCC08G18/12C08G18/4202C08G18/4277C08G18/4269C08G18/664A61L27/34A61L27/58A61L27/18A61L31/06A61L31/148A61L2400/16C08G2230/00C08L75/06C08G18/3206
Inventor 陈思翀王曼吴刚王玉忠
Owner SICHUAN UNIV
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