Anti-adhesion tendon material and preparation method thereof

An anti-adhesion and tendon technology, applied in pharmaceutical formula, medical science, prosthesis, etc., can solve the problems of unfavorable tendon tissue to obtain nutrients, prolong the regeneration and reconstruction process of tendon tissue, and lack of targeting of immune regulation, reaching the shelf Long effective period, shorten the time of regeneration and reconstruction, easy to obtain the effect
CN114569792AActive Publication Date: 2022-06-03BEIJING XINKANGCHEN MEDICAL SCI & TECH DEV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BEIJING XINKANGCHEN MEDICAL SCI & TECH DEV
Publication Date
2022-06-03

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Abstract

The invention discloses an anti-adhesion tendon material and a preparation method thereof. The tendon material is composed of regulatory T lymphocyte exosomes and tendons, and is prepared by compounding the T lymphocyte exosomes and the tendons and then freeze-drying the T lymphocyte exosomes and the tendons. The tendon tissue of the prepared composite Treg cell exosome is exposed in body fluid, nutrient substances can be fully obtained, the growth of implanted tendon cells into the tendon tissue can be accelerated, the regeneration and reconstruction time of the tendon tissue can be shortened, the Treg cells can be cultured on a large scale, the Treg cell exosome is easy to obtain, and after the Treg cell exosome and the tendon material are freeze-dried, the preparation process is simple, and the preparation cost is low. The tendon material can be stored for a long time under the refrigeration condition or the room temperature condition, the shelf life is long, and the prepared tendon material is convenient to use and does not need physical isolation.
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Description

technical field

[0001] The invention belongs to the technical field of tissue engineering regenerative medical products, in particular to an anti-adhesion tendon material and a preparation method thereof. Background technique

[0002] Tendon injuries are a common sports injury that usually requires surgical repair or suturing. Due to the poor blood supply of the tendon, it is difficult for the tendon to heal itself after injury. About 40% of the patients will experience different degrees of tendon adhesion after surgery, which seriously affects the functional recovery of the patients. Current research believes that tendon adhesion is a kind of aseptic fibroproliferative inflammatory reaction of the body. The body releases vasoactive substances and cytokines such as histamine and bradykinin under the stimulation of various physical, chemical and biological factors, which makes the local Increased capillary permeability, leading to congestion, edema, and the formation of infl...

Claims

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