Core/shell type polyurethane magnetic compound microsphere, preparation method and use thereof

A magnetic composite microsphere and polyurethane technology, applied in biochemical equipment and methods, microorganisms, pharmaceutical formulations, etc., can solve the problems of difficult control of magnetic properties and weak magnetic response of microspheres, and achieve low production cost and stable suspension performance good, low density effect

Inactive Publication Date: 2007-05-23
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Applied Chemistry, 1997, 14 (5): 74-76), on the surface of the magnetic particles, the swelling initiator polymerization reaction occurs on the surface of the magnetic particles, and the large particle size microspheres with a particle size of 50-500 microns are produced, but this The magnetic response of microspheres prepared by this method is relatively weak, and the magnetic properties are not easy to control

Method used

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  • Core/shell type polyurethane magnetic compound microsphere, preparation method and use thereof
  • Core/shell type polyurethane magnetic compound microsphere, preparation method and use thereof
  • Core/shell type polyurethane magnetic compound microsphere, preparation method and use thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0037] Weigh 2 grams of BaFe 12 o 19 The powder was added to a mixed solution containing 200 ml of distilled water and 200 ml of absolute ethanol, and 4.8 ml of N-β-aminopropyltrimethoxysilane (HC-792) was added dropwise to the solution for ultrasonic dispersion for 10 minutes. Dry the three-necked flask with a condenser tube and a mechanical stirrer, heat it to 70°C with closed stirring, react at a constant temperature for 5 hours, let it stand for washing with water, separate the solid from the liquid, dry it in a constant temperature blast drying oven at 80°C for 5 hours, and grind it to obtain a modified Sexual BaFe 12 o 19 Powder ready for use.

[0038] Weigh 1 gram of modified BaFe 12 o 19The powder was added to a dry vial with 70 milliliters of xylene and ultrasonically dispersed for 10 minutes, 5 milliliters of toluene diisocyanate was added dropwise, and sealed and stirred at room temperature for 50 minutes, after adding 10 grams of PEG and 1.5 milliliters of tol...

Embodiment 2

[0040] Weigh 1 gram of modified BaFe 12 o 19 Powder, add to a dry vial containing 70 ml of xylene and ultrasonically disperse for 10 minutes, add 5 ml of toluene diisocyanate dropwise, seal and stir at room temperature for 50 minutes, add 10 grams of polyethylene glycol 1000, 1.5 ml of toluene diisocyanate and stir for 120 minutes Finally, the xylene solution of the prepolymer is dropped into the three-necked flask containing 1% (mass / volume) polyvinylpyrrolidone and 300 milliliters of aqueous solution of a few drops of triethanolamine, and 1.5 milliliters of chain extender glycerol is added. Heat to 70° C. with sealing and stirring, react at constant temperature for 5 hours, wash the obtained product 4 to 5 times, magnetically separate, soak in 50% (volume) ethanol solution for 12 hours, and dry to obtain brown microspheres. The particle size of the microspheres is 200-300 microns.

Embodiment 3

[0042] Weigh 2 g Fe 3 o 4 The powder is added to a mixed solution containing 200 ml of distilled water and 200 ml of absolute ethanol, and 4.8 ml of N-β-aminopropyltrimethoxysilane is added dropwise to the solution for ultrasonic dispersion for 10 minutes. In a dry three-necked flask, close and stir and heat to 70°C, react at a constant temperature for 5 hours, stand still and wash with water, separate solid and liquid, dry in a constant temperature blast drying oven at 80°C for 5 hours, and grind to obtain modified Fe 3 o 4 Powder ready for use.

[0043] Weigh 1 gram of modified Fe 3 o 4 Powder, add to a dry vial containing 70 ml of xylene and ultrasonically disperse for 10 minutes, add 9.5 ml of diphenylmethane diisocyanate dropwise, add polyester polyol with a hydroxyl value of 55 ± 3 mg KOH / g, M = 2000 15 grams, sealed and stirred at room temperature for 180 minutes, the xylene solution of the prepolymer was dropped into a three-necked flask containing 1% (mass / volume...

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Abstract

The invention relates to a corn/case polyurethane magnetic composite micro ball, and relative preparation, wherein it uses inorganic magnetic particles as corn, uses polyurethane as case, while its diameter reaches 800micrometer; and its production comprises that: planting -NH and -NH2 groups on the surface of magnetic inorganic powder; than polymerizing into polyurethane prepolymer; forming stable oil/water suspension in the disperser solution; then polymerizing into magnetic inorganic/ polyurethane magnetic composite micro ball. The inventive micro ball has X-ray contrast, high magnetic response and low density of polyurethane macromolecule, etc. And inventive production has simple process and low cost. Said micro ball can be used to prepare vessel plunge material and drug carrier.

Description

technical field [0001] The invention relates to a method for preparing core / shell polyurethane magnetic composite microspheres by solution polymerization. Background technique [0002] Magnetic polymer composite microspheres combine the advantages of both magnetic inorganic materials and polymer materials, and have many excellent properties, such as magnetic responsiveness, which can be easily separated under the action of an external magnetic field, and low density. Good suspension stability. The microphase separation structure of polyurethane makes it have better biocompatibility (including blood compatibility and tissue compatibility) than other polymer materials, and has excellent high elasticity and high strength, while barium ferrite material has good Excellent X-ray imaging and excellent magnetic responsivity. Combining the advantages of both, polyurethane magnetic composite microspheres are insoluble in water, stable in nature, non-biodegradable in vivo, have good ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/06A61L31/02A61K47/34A61K47/02C12N11/00C12N5/00
Inventor 戴红莲周超李世普韩颖超王欣宇李建华贾莉
Owner WUHAN UNIV OF TECH
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