The invention discloses a buyer inquiry and seller quotation automatic matching system and method. The method comprises: S1, a seller registering basic information of a product through a product delivery module; S2, making a product pricing strategy through an inquiry strategy management module; S3, a buyer inputting a screening condition through a product screening module to obtain a target product; S4, submitting an inquiry sheet through an inquiry module; S5, an inquiry automatic processing module, according to the inquiry sheet information submitted by the buyer, querying a matched product price in a price strategy information data base, the product price and the inquiry sheet forming an offer; S6, receiving an quoted price of the offer, forming a transaction, or resubmitting the inquiry sheet and skipping to S4; and S7, the buyer and the seller tracking the state of the formed transaction in a transaction order management module. By using the system and method provided by the invention, automatic trading can be realized, the buying disadvantage under information asymmetry is eliminated, the rice adjusting capability under an information full transparent condition can be ensured, and large-scale matching transactions on the Internet can be guaranteed.