Method for preparing multi-responsive block copolymer containing azopyridine

Abstract

The invention belongs to the field of functional polymer materials and in particular relates to a method for preparing a multi-responsive block copolymer containing azopyridine. The preparation method is characterized by synthesizing azopyridine with photo-responsivity through a diazo coupling reaction and then reacting azopyridine with 6-chloro-1-hexanol and methacryloyl chloride in sequence to prepare a methacrylate monomer containing an azopyridine group; then synthesizing a methacrylic acid-N,N-(dimethylamino)ethyl monomer into a macroinitiator through atom transfer radial polymerization (ATRP) under the protection of an inert gas nitrogen or argon, wherein the block has temperature sensitivity and temperature responsivity; and finally synthesizing the macroinitiator with an azopyridine monomer to prepare the multi-responsive block copolymer containing azopyridine through ATRP. The method has the following advantages that the block copolymer simultaneously has photo-responsivity, pH sensitivity and temperature sensitivity and can be self-assembled into various aggregation morphologies such as stable nano micelle and vesicles in water, so the block copolymer is widely applied in the fields such as drug controlled release carriers, smart photo switches, photo sensors and nano devices; the synthesis method is simple and practical; the raw materials can be industrially produced; and the method has good popularization and application values.

Description

technical field

[0001] The invention belongs to the field of polymer materials, and in particular relates to a preparation method of an azopyridine-containing multi-responsive block copolymer. Background technique

[0002] Photoresponsive polymer is a smart polymer material that responds to changes in physical and chemical properties such as its shape, color, and hardness under the stimulation of external light signals such as ultraviolet light and infrared light. Among them, there are many studies on the responsiveness of azobenzene polymers to ultraviolet light, but few studies on azopyridine photoresponsive polymers. Such materials have broad applications in the fields of optical smart switching, optical sensors, and light-to-power conversion devices. Amphiphilic azopyridines can self-assemble into micelles or vesicles, and can also be applied to the field of biological drug delivery.

[0003] The trans configuration of azopyridine is relatively stable under visible lig...

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