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Water dispersible granule formulated by azoxystrobin and cymoxanil and preparation method thereof

A technology of azoxystrobin and cymoxanil, which is applied in the field of preparation of water-dispersible granules, can solve the problems of endangering human health, environmental pollution, and high use cost, and achieve the effects of less environmental pollution, low control cost, and small use dose

Inactive Publication Date: 2012-09-19
LIMIN CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the disadvantages of environmental pollution, harm to human health, and high cost of use in the prior art, the purpose of the present invention is to provide a water-dispersed compound of azoxystrobin and cymoxanil with good drug effect, high content, and environmental protection. Granules

Method used

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  • Water dispersible granule formulated by azoxystrobin and cymoxanil and preparation method thereof
  • Water dispersible granule formulated by azoxystrobin and cymoxanil and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Weigh raw material components: azoxystrobin 60%, cymoxanil 15%, wetting agent T1004 3%, dispersant T2700 7%, disintegrant ammonium sulfate 4%, diluent kaolin 6%, disinfectant Foaming agent EP6703 2%, binder polyethylene glycol 72 2%, mix the above raw material components, stir evenly, and pulverize with a jet mill to obtain mother powder with a particle size of 400 mesh or more, and then add 30% of the raw material mass The deionized water is fully mixed with a mixing mixer, granulated with a granulator, then dried by a dryer, and passed through a sieve with 8 mesh and 40 mesh sieves to obtain a compound of 60% azoxystrobin and 15% cymoxanil water dispersible granules. After testing, the content of azoxystrobin is 60%, the suspension rate of azoxystrobin is 85%, the content of cymoxanil is 15.4%, the suspension rate of cymoxanil is 81%, the water content is 1.9%, the sieving (44μm sieve) is 98.3%, and the long-lasting foaming property (1 min) 14mL, the disintegration t...

Embodiment 2

[0030] Weigh raw material components: azoxystrobin 55%, cymoxanil 20%, wetting agent EFW 4%, dispersant D-425 6%, disintegrant sodium sulfate 5%, diluent diatomaceous earth 6%, defoaming agent EP6703 1%, binder carboxymethyl cellulose 2%, mix the above raw material components, stir evenly, and pulverize through a jet mill to obtain mother powder with a particle size of 400 mesh or more, and then add raw materials Deionized water with a quality of 30%, fully mixed with a mixing mixer, granulated with a granulator, then dried by a dryer, passed through a sieve of 8 mesh and 40 mesh by a sieving machine to obtain 55% azoxystrobin and 20% cream urea Cyanide compounded water dispersible granules. After inspection, the content of azoxystrobin is 55.6%, the suspension rate of azoxystrobin is 87%, the content of cymoxanil is 20.2%, the suspension rate of cymoxanil is 83%, the water content is 1.7%, the sieving (44μm sieve) is 99.1%, and the long-lasting foaming property (1min) 10mL, ...

Embodiment 3

[0032] Weigh raw material components: azoxystrobin 50%, cymoxanil 25%, wetting agent WP 3%, dispersant calcium lignosulfonate 7%, disintegrant sodium citrate 4%, defoaming agent Agent EP6703 1%, diluent light calcium 8% to make up. After the above raw material components are mixed evenly, they are pulverized by an airflow mill to obtain mother powder with a particle size of 400 mesh or more, then add deionized water with a mass of 30% of the raw material, fully mix with a mixing mixer, and granulate with a granulator, and then pass through Dried in a dryer, passed through a sieving machine with 8 mesh and 40 mesh sieves to obtain a water-dispersible granule compounded with 50% azoxystrobin and 25% cymoxanil. After testing, the content of azoxystrobin is 50.4%, the suspension rate of azoxystrobin is 86%, the content of cymoxanil is 25.5%, the suspension rate of cymoxanil is 82%, the water content is 1.5%, the sieving (44μm sieve) is 98.9%, and the long-lasting foaming property ...

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Abstract

The invention discloses a water dispersible granule formulated by azoxystrobin and cymoxanil and a preparation method of the water dispersible granule. The water dispersible granule contains the following materials by mass: 20% to 60% of azoxystrobin original drug, 10% to 50% of cymoxanil original drug, 3% to 4% of wetting agent, 6% to 7% of dispersant, 4% to 5% of disintegrant and 6% to 15% of diluent, and also contains about 2% of binder and 1% to 2% of antifoaming agent. The method comprises the following steps: (1) taking the following raw material ingredients by weight: the azoxystrobin original drug, the cymoxanil original drug, the wetting agent, the dispersant, the disintegrant and the diluent, and uniformly mixing the raw materials; (2) pulverizing the above mixed materials with a jet pulverizer to obtain mother powder with particle size of more than 400 meshes; (3) adding deionized water into the mother powder, thoroughly mixing with a stirrer, granulating with a granulator, then drying with a dryer, and screening granules with a 8-mesh screen and a 40-mesh screen with a screening machine to obtain the water dispersible granule formulated by azoxystrobin and cymoxanil. The water dispersible granule provided by the invention has the advantages of broad spectrum antibiotic, high content of active component, fast disintegration and good dispersion properties, stable thermal storage performance and the like.

Description

technical field [0001] The invention relates to the field of pesticide preparation, in particular to a preparation process of water-dispersible granules. Background technique [0002] At present, there are many agricultural fungicides, azoxystrobin and cymoxanil are two of them. Azoxystrobin is a methoxyacrylate fungicide. Its original drug is a brown solid with a melting point of 114-116°C. The pure product is a white crystal with a melting point of 116°C and a relative density of 1.34. The solubility in water is 6mg / L (20°C). Soluble in methanol, toluene, acetone, slightly soluble in n-octanol, hexane, easily soluble in ethyl acetate, acetonitrile, dichloromethane. The half-life of photolysis in aqueous solution is 2 weeks, and it is stable to hydrolysis. Acute oral LD50 of rats and mice (male and female) > 5000mg / kg, acute oral LD50 of rats > 2000mg / kg, slightly irritating to rabbit skin and eyes. Rat acute inhalation LC50 (mg / L): male 0.96, female 0.69. No tera...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N47/34A01N43/54A01N25/14A01P3/00
Inventor 孙敬权徐勤江陈金华刘念江孙丽梅陈婧
Owner LIMIN CHEM CO LTD
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