Cranioplasty prosthesis with biological activity and preparation method of cranioplasty prosthesis

A bioactive, cranial technology, applied in the field of biomedicine, can solve problems such as difficulty in shaping titanium mesh, cerebrospinal fluid leakage and infection, puncture of the skull cortex, etc., to achieve reliable safety and effectiveness, improve wettability and adhesion The effect of stability and stable mechanical properties

Inactive Publication Date: 2015-06-03
MEDPRINSHENZHEN REGENERATIVEA MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0004] (1) When the titanium mesh is formed, it will produce sharp edges, which will puncture the cortex of the skull, causing discomfort to the patient and even causing cerebrospinal fluid leakage and infection;
[0005] (2) The temperature conductivity of the titanium mesh is strong, and it cannot be fused with the autogenous bone, and the patient is prone to intracranial discomfort;
[0006] (3) Titanium mesh will undergo electrochemical reactions in the human body, releasing heavy metal ions, causing inflammation, and may even lead to tissue necrosis;
[0007] (4) It is difficult to shape the titanium mesh. After shaping, the resilience of the titanium mesh is relatively large, and multiple stress reliefs are required. The operation is complicated and takes a long time;
[0008] (5) Titanium mesh cannot penetrate X-rays, which is not conducive to postoperative observation and evaluation
Although the artificial skull prepared by laser-cured 3D printing technology is accurate in size and does not require secondary plasticity, the material after curing is an ABS-like material, and its rigidity, strength, and fatigue resistance cannot meet the requirements of human bone. Biological tests in the United States, but there is no report that this material can be used as an implantable material for human hard tissue replacement, and it still takes a long time for clinical application development
[0012] Chinese patent CN102490350A discloses a skull repair prosthesis that uses PEEK as a skull repair material and is prepared by hot pressing; PEEK has good biocompatibility and a relatively high molding temperature. This patent uses its softening temperature for processing and molding. The molded product has a large internal stress, which will cause the product to deform and cause the size of the product to change, which brings safety hazards to long-term implantation
And although the PEEK material has excellent mechanical properties, it is a biologically inert material, which is not conducive to the adhesion and growth of cell tissues, which affects wound healing.

Method used

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  • Cranioplasty prosthesis with biological activity and preparation method of cranioplasty prosthesis

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preparation example Construction

[0061] The present invention also provides a method for preparing the skull repair prosthesis as described above, the method comprising the following steps:

[0062] (1) Using selective laser sintering 3D printing technology, polyaryletherketone powder was used as raw material to prepare unmodified skull repair prosthesis layer;

[0063] (2) immersing the unmodified skull repair prosthesis layer in step (1) in the solution, and modifying under irradiation to obtain a modified skull repair prosthesis layer;

[0064] (3) Coating the nanofibrous film layer on the modified skull repair prosthesis layer in step (2).

[0065] As a preferred technical scheme, the preparation method of the above-mentioned skull repair prosthesis comprises the following steps:

[0066] (1) Using selective laser sintering 3D printing technology, polyaryletherketone powder is used as a raw material to prepare an unmodified skull repair prosthesis layer, and through holes are set on the unmodified skull ...

Embodiment 1

[0094] refer to figure 1 , the method for preparing 2-methacryloyloxyethyl phosphorylcholine modified polyether ketone ketone (PEKK) skull repair prosthesis is as follows:

[0095] (1) Use computerized tomography to scan the patient's skull with a scanning interval of 0.5 mm, store the scanned image in dicom format, read the data with Mimics software, segment and extract the skull data, and reconstruct the three-dimensional model of the skull And save it in stl format; then import it into 3-matic software, process the obtained 3D model, generate a cranial prosthesis that matches the original skull, and store it in stl format; import the stl file into selective laser sintering 3D printer (sPro60, 3D system), using implantable grade polyether ketone ketone (PEKK) powder as raw material to print the defect part of the skull repair prosthesis, that is, to obtain the unmodified skull repair prosthesis layer 3;

[0096] (2) The above-mentioned unmodified skull repair prosthesis lay...

Embodiment 2

[0099] refer to figure 1 , the method for preparing methacrylic acid-modified polyetheretherketone (PEEK) skull repair prosthesis is as follows:

[0100] (1) Use computed tomography technology to scan the patient's head with a scanning interval of 0.5mm, store the scanned image in dicom format, read the data with mimics software, segment and extract the skull data, and reconstruct the three-dimensional model of the skull , and then imported into 3-matic software to process the obtained 3D model to generate a skull repair prosthesis that matches the original skull and store it in stl format; import the stl file into a selective laser sintering 3D printer (sPro60, 3D system), using implantable grade polyetheretherketone (PEEK) powder as raw material to print the defect part of the skull repair prosthesis, that is, to obtain the unmodified skull repair prosthesis layer 3;

[0101] (2) The above-mentioned unmodified skull repair prosthesis layer 3 is immersed in the methacrylic a...

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Abstract

The invention relates to cranioplasty prosthesis with biological activity and a preparation method of the cranioplasty prosthesis. The cranioplasty prosthesis with biological activity sequentially comprises an unmodified cranioplasty prosthesis layer, a modified cranioplasty prosthesis layer and a nanofiber membrane layer from inside to outside. The invention further provides a preparation method of the cranioplasty prosthesis. By virtue of a three-layer structure and polyaryletherketone materials which are equivalent to a bone of a human body in hardness, strength and weight, are good in biocompatibility, and a 3D printing technology, a cranioplasty prosthesis implant has reliably safety and effectivity and high matching degree. The cranioplasty prosthesis provided by the invention is capable of loading a plurality of bionic scaffolds and bioactive substances, and promoting exchange of nutrient substances inside and outside the prosthesis, and is beneficial to growth of tissues.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a skull repair prosthesis and a preparation method thereof, in particular to a biologically active skull repair prosthesis and a preparation method thereof. Background technique [0002] Craniotomy is required when trauma, intracranial infection and tumor, cerebral edema, intracranial hypertension, skull deformity and other diseases occur on the human head, which can easily cause skull defects. After the skull defect, the brain tissue will lose its protection and affect the life of the patient. In order to prevent the brain tissue from being damaged by external force, the closure of the skull and the appearance of the patient are not affected, it is necessary to perform cranioplasty. [0003] Most of the existing skull repairs use titanium mesh for repair. Titanium mesh has the characteristics of non-toxicity, high strength, good biocompatibility and safety. Howev...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/26A61L27/54A61L27/34A61L27/56B29C67/00B33Y10/00
Inventor 李广耀徐弢袁玉宇
Owner MEDPRINSHENZHEN REGENERATIVEA MEDICAL TECH CO LTD
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