A bioactive skull repair prosthesis and preparation method thereof

Abstract

The invention relates to cranioplasty prosthesis with biological activity and a preparation method of the cranioplasty prosthesis. The cranioplasty prosthesis with biological activity sequentially comprises an unmodified cranioplasty prosthesis layer, a modified cranioplasty prosthesis layer and a nanofiber membrane layer from inside to outside. The invention further provides a preparation method of the cranioplasty prosthesis. By virtue of a three-layer structure and polyaryletherketone materials which are equivalent to a bone of a human body in hardness, strength and weight, are good in biocompatibility, and a 3D printing technology, a cranioplasty prosthesis implant has reliably safety and effectivity and high matching degree. The cranioplasty prosthesis provided by the invention is capable of loading a plurality of bionic scaffolds and bioactive substances, and promoting exchange of nutrient substances inside and outside the prosthesis, and is beneficial to growth of tissues.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a skull repair prosthesis and a preparation method thereof, in particular to a biologically active skull repair prosthesis and a preparation method thereof. Background technique [0002] Craniotomy is required when trauma, intracranial infection and tumor, cerebral edema, intracranial hypertension, skull deformity and other diseases occur on the human head, which can easily cause skull defects. After the skull defect, the brain tissue will lose its protection and affect the life of the patient. In order to prevent the brain tissue from being damaged by external force, the closure of the skull and the appearance of the patient are not affected, it is necessary to perform cranioplasty. [0003] Most of the existing skull repairs use titanium mesh for repair. Titanium mesh has the characteristics of non-toxicity, high strength, good biocompatibility and safety. Howev...

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Problems solved by technology

[0004] (1) When the titanium mesh is formed, it will produce sharp edges, which will puncture the cortex of the skull, causing discomfort to the patient and even causing cerebrospinal fluid leakage and infection;

[0005] (2) The temperature conductivity of the titanium mesh is strong, and it cannot be fused with the autogenous bone, and the patient is prone to intracranial discomfort;

[0006] (3) Titanium mesh will undergo electrochemical reactions in the human body, releasing heavy metal ions, causing inflammation, and may even lead to tissue necrosis;

[0007] (4) It is difficult to shape the titanium mesh. After shaping, the resilience of the titanium mesh is relatively large, and multiple stress reliefs are required. The operation is complicated and takes a long time;

[0008] (5) Titanium mesh cannot penetrate X-rays, which is not conducive to postoperative observation and evaluation

Although the artificial skull prepared by laser-cured 3D printing technology is accurate in size and does not require secondary plasticity, the material after curing is an ABS-like material, and its rigidity, strength, and fatigue resistance cannot meet the requirements of human bone. Biological tests in the United States, but there is no report that this material can be used as an implantable material for human hard tissue replacement, and it still takes a long time for clinical application development

[0012] Chinese patent CN102490350A discloses a skull repair prosthesis that uses PEEK as a skull repair material and is prepared by hot pressing; PEEK has good biocompatibility and a relatively high molding temperature. This patent uses its softening temperature for processing and molding. The molded product has a large internal stress, which will cause the product to deform and cause the size of the product to change, which brings safety hazards to long-term implantation

And although the PEEK material has excellent mechanical properties, it is a biologically inert material, which is not conducive to the adhesion and growth of cell tissues, which affects wound healing.

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