A kind of preparation method of multifunctional composite microsphere

Abstract

The invention provides a preparation method for multifunctional composite microspheres. Through introduction of natural high polymers, a solvothermal method is employed to synthesize functional magnetic nanoparticles and carbon quantum dots synchronously, the surfaces of the magnetic nanoparticles are coated with a metal-organic framework material, according to surface porous structure and charge difference, and the fluorescent carbon quantum dots are connected successfully through electrostatic adsorption and physical adsorption. The fluorescence quenching effect of the magnetic nanoparticles to carbon quantum dots is overcome, the material specific surface area is raised, and the pH response performance is given to the material. The multifunctional integrated composite material can be used in fields of catalysis, adsorption and immunodetection, targeting treatment, cell separation and the like in medical science.

Description

technical field [0001] The invention relates to a preparation method of a drug-loaded microsphere material, in particular to a preparation method of a magnetic-optical-high specific surface area multifunctional composite microsphere carrier material. Background technique [0002] 1. The importance of preparing multifunctional materials with high drug loading, fluorescent tracer and specific targeted drug delivery. [0003] The harm of cancer on a global scale is increasing, which seriously threatens human health. Surgery and traditional chemotherapy are the most commonly used cancer treatment methods in clinical practice at this stage. Chemotherapy mainly treats cancer through systemic administration, that is, the drug enters the blood circulation through the administration site, and is transported to various organs and tissues by the circulatory system. However, most anticancer drugs have poor water solubility and stability, resulting in low bioavailability of drugs. Almo...

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Problems solved by technology

[0005] 2. The combination of existing technologies is difficult to prepare multifunctional materials with high drug loading, fluorescent tracer and specific targeted drug delivery. The combination of magnetic materials and fluorescent materials is usually due to lattice mismatch, or the size distribution is difficult to control, and the preparation process is repeated. Poor performance, especially the fluorescence quenching effect of magnetic nanoparticles on fluorescent materials due to light absorption and electron transfer is more serious, which leads to difficulties in combining magnetic materials with fluorescent materials

[0006] Between pH-responsive materials and magnetic nanoparticles, if magnetic nanoparticles are wrapped inside, the magnetic responsiveness of the material will be reduced, and if magnetic nanoparticles are loaded outside, the pH-responsiveness of the material itself will be weakened, leading to the selection of the combination form between the two. It is difficult; it is also difficult to reach an agreement between the drug loading and the pH-responsive carrier material. At present, the pH-responsive drug carrier materials are generally polymer materials with special chemical bonds, mainly through controlling the formation of drug molecules under acidic conditions. The chemical bond is broken to achieve the required pH responsiveness. If you want to ensure other functions, the inner coating will occupy the space of the drug, and the outer load will reduce the drug loading of the material because of its small specific surface area; if the The combination of the four is even more difficult. It is not only necessary to overcome the barriers between each other, but also to consider the shape, particle size and dispersion control of multiple functional materials, as well as the guarantee of water solubility and biological safety of the materials. Preventing capillary embolism, the large difference in the concentration of effective therapeutic drugs in the whole body and other problems limit the clinical medical effect of the material

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