Multi-functional bismuth selenide nanocomposite and preparation method and application thereof

A nanocomposite, bismuth selenide technology, applied in the field of biomedicine, can solve the problems of complex synthesis conditions and processes of thermochemotherapeutic nanomaterials, lack of clinical experiment verification, lack of imaging diagnostic functions, etc., to achieve excellent photothermal heating performance, preparation Conditions and procedures are simple, the effect of significant chemotherapy effect

Active Publication Date: 2016-03-30
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The present invention aims to solve the problems of complex synthesis conditions and processes, poor biological safety, low drug loading, lack of suitable imaging diagnostic function, photothermal performance and lack of clinical experiment verification in the existing thermal chemotherapy nanomaterials, and provides a A kind of multifunctional bismuth selenide nanocomposite, its preparation method and application

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  • Multi-functional bismuth selenide nanocomposite and preparation method and application thereof
  • Multi-functional bismuth selenide nanocomposite and preparation method and application thereof
  • Multi-functional bismuth selenide nanocomposite and preparation method and application thereof

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specific Embodiment approach 1

[0032] Specific embodiment one: a kind of multifunctional bismuth selenide nanocomposite of this embodiment, it uses organic high molecular polymer, glycol, selenium source, bismuth salt, reducing agent, dopamine hydrochloride, trihydroxymethyl amino Prepared from methane hydrochloride solution, doxorubicin hydrochloride and serum albumin aqueous solution as raw materials, the particle size of the multifunctional bismuth selenide nanocomposite is 50nm-200nm, and the multifunctional bismuth selenide nanocomposite The drug loading amount of doxorubicin hydrochloride is 3%-10%.

specific Embodiment approach 2

[0033] Embodiment 2: The difference between this embodiment and Embodiment 1 is that: the organic high molecular polymer is a mixture of one or two of polyvinylpyrrolidone and polyacrylic acid; the diol is ethylene glycol , propylene glycol and butylene glycol or a mixture of several thereof; the selenium source is one or a mixture of several of them in sodium selenite, potassium selenite and selenium dioxide; the bismuth salt It is one or a mixture of bismuth nitrate, bismuth chloride and bismuth acetate; the reducing agent is one or a mixture of hydroxylamine, morpholine borane, sodium borohydride, glucose and ascorbic acid; The pH of the tris hydrochloride solution is 8.0 to 10; the serum albumin aqueous solution is a mixture of one or both of human serum albumin aqueous solution and bovine serum albumin aqueous solution, and the serum albumin The concentration of the aqueous solution was 5.0 mg / mL. Others are the same as the first embodiment.

specific Embodiment approach 3

[0034] Specific embodiment three: the preparation method of a kind of multifunctional bismuth selenide nano-composite of this embodiment is carried out according to the following steps:

[0035] 1. Completely dissolve the organic high molecular polymer in the glycol to obtain a reaction system, add selenium source and bismuth salt into the reaction system, and after ultrasonic mixing, heat up at a heating rate of 10°C / min~20°C / min The temperature of the reaction system is raised from room temperature to 100°C to 250°C, then a reducing agent is added to the reaction system, react for 5min to 30min at a temperature of 100°C to 250°C, and then cool to room temperature, using a mixture of acetone and water Centrifuge and wash 3 to 5 times, collect the sample, and dry it in vacuum to obtain Bi 2 Se 3 Nanosheet; the volume ratio of water and acetone in the mixed solution of acetone and water is 1:(1~5); the volume ratio of the quality of the organic high molecular polymer and dibas...

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Abstract

The invention relates to the field of biomedicine, in particular to a multi-functional bismuth selenide nanocomposite and a preparation method and application thereof. The multi-functional bismuth selenide nanocomposite aims to solve the problems that the synthesis condition and process of the existing hyperthermia chemotherapy nano material are complex, the biological safety is poor, the drug loading capacity is low, the existing hyperthermia chemotherapy nano material is short of an appropriate imaging diagnosis function, the heat-light properties need to be improved, and the existing hyperthermia chemotherapy nano material is short of clinical experimental verification. The grain size of the multi-functional bismuth selenide nanocomposite is 50 nm to 200 nm, and the drug loading capacity for loading doxorubicin hydrochloride is 3% to 10%. The preparation method comprises a step 1 of preparing Bi2Se3 nanosheets; a step 2 of preparing Bi2Se3@PDA nano particle dispersion liquid; and a step 3 of preparing the multi-functional bismuth selenide nanocomposite. The multi-functional bismuth selenide nanocomposite serves as the hyperthermia chemotherapy nano material to be utilized in hyperthermia chemotherapy of a malignant tumor or serves as a CT imaging contrast agent to be utilized in CT imaging diagnosis of the malignant tumor.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a multifunctional bismuth selenide nanocomposite, its preparation method and application. Background technique [0002] Photothermal therapy is a new treatment technology based on near-infrared laser that is non-invasive and can quickly kill tumors developed in recent years. Its principle is to use nanomaterials with photothermal conversion function (photothermal therapeutic agent) The light energy is converted into heat to heat the tumor tissue. When the temperature reaches above 42 degrees, the tumor tissue will undergo apoptosis or necrosis, while the normal tissues or organs of the human body will not be harmed. However, in order to make photothermal therapy more effective and safe, it is urgent to diagnose the tumor location, size and contour before photothermal therapy, and to determine the enrichment and concentration of photothermal therapeutic agents in the lesion during the t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/04A61K41/00A61K31/704A61K47/02A61P35/00
CPCA61K31/704A61K41/0052A61K47/02A61K49/04A61K2300/00
Inventor 于淼李正林孙晔李卓范雪蕾
Owner HARBIN INST OF TECH
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